Browsing by Author "Anand, A"
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Publication Juvenile Generalized Myasthenia Gravis: Presented as Unilateral Blepharoptosis and Successfully Managed with Pulse Intravenous Methylprednisolone(Kathmandu University, 2021) Poudel, P; Anand, A; Ghosh, SABSTRACT Myasthenia Gravis is a rare autoimmune disorder of childhood and this is rarer in South Asia. We present a pre-pubertal 7 year old female child of seropositive Generalized Juvenile Myasthenia Gravis. She presented with unilateral blepharoptosis and later generalized symptoms appeared. Ice-pack test, Neostigmine challenge test and acetylcholine receptor antibody test were positive. Serum muscle specific tyrosine kinase antibody test was normal. She did not have thymic abnormalities. She did not respond to high dose (26 mg/kg/day) of Pyridostigmine and oral Prednisolone (2 mg/kg/day), but was successfully treated with a combination of pulse intravenous Methylprednisolone (30 mg/kg once a month for 6 months) and daily doses of oral Prednisolone (2 mg/kg/day) along with Pyridostigmine without significant side effects. This combination can be considered a potential inexpensive treatment for Juvenile Myasthenia Gravis in a resource limited area where other immunosuppressive treatments such as intravenous immunoglobulin is expensive and unaffordable. KEY WORDS Blepharoptosis, Child, Methylprednisolone, Muscle weakness, Myasthenia gravisPublication Malathion induced changes on hepatic acid and alkaline phosphatases in developing rats(Institute of Medicine, 2001) Seal, Reneta; Jha, B; Sen, P; Anand, AAbstract The effect of malathion, an organophosphorous pesticide, was assessed on the biochemical nature of the hepatic organ. Malathion was administered per os at doses of 5mg, 50mg, 250mg and 500mg/kg body weight at a time interval of 24 hours to developing rats of Charles Foster Strain. Enzyme activities, e.g. acid phosphates and alkaline phosphates estimated would indicate that malathion may induce possible cellularlysis and tissue degeneration at high doses during developing stage. Keywords: Malathion, acid phosphatases, alkaline phosphatases