Browsing by Author "Aryal, Saroj Babu"
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Publication Clinical Profile of Metabolic Derangements in Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease(Nepal Health Research Council, 2024) Aryal, Saroj Babu; Panthi, Akriti; Aryal, Nadira; Risal, BijayBackground: Chronic obstructive pulmonary disease is defined as a preventable and treatable disease characterized by persistent respiratory symptoms and airflow limitation attributable to airway accompanied by alveolar abnormalities elicited by significant exposure to noxious particles or gases. Stress hormone is involved in proclivity towards causation of hyperglycemia and hyponatremia in COPD. Methods: This study is an analytical cross sectional single center study that was carried out in Tribhuvan University Teaching Hospital. Specimens were processed as per the guidelines of Standard Operating Procedure (SOP) of Biochemistry laboratory of Tribhuvan University Teaching Hospital. Results: In this study of 138 patients with acute exacerbation of COPD, the mean age was (71.88±9.771) years with higher prevalence in the age group between 70-80 years of age. Females (65.2%) outnumbered males and 71.7% came from outside the Kathmandu valley. Hyponatremia was observed in sodium levels with 51.4% below normal with majority of patient’s possessing mixed acid-base disorders (58.7%). Most of thepatients 76.5% received general care with a mean hospital stay of 8.7 days. Statistical analysis revealed significant associations between care type, geographical distribution (p=0.026) and duration of stay with care type (p=0.0001). No significant associations were found regarding gender, glucose, sodium, potassium levels and age with duration of stay. Conclusions: Factors such as age, gender, and glycemic status did not significantly affect the type of care or duration of hospital stay, geographical location emerged as a significant determinant, with patients from outside the Kathmandu valley more likely to receive general care. Despite the prevalence of electrolyte imbalances and acid-base disorders, these biochemical factors showed no substantial impact on clinical outcomes, suggesting that other factors may play a more significant role in duration of stay. Keywords: Acid-base imbalance; biochemistry; glucose; potassium; pulmonary.Publication Conjunction of ovarian dermoid cyst in a patient with Pituitary Micro Adenoma: A Case Report(Nepal Medical Association, 2025) Aryal, Saroj Babu; Chitrakar, Shasank; Panthi, AkritiAbstract Pituitary adenomas are common intracranial tumors, and ovarian dermoids are frequently encountered benign gynecological lesions. While both conditions are individually prevalent, their co-existence is rare and infrequently reported. This unusual combination may pose diagnostic challenges and warrants further exploration to determine any potential underlying link. We present a case of a 42-year-old Hindu female who was diagnosed case of a pituitary adenoma with a leftsided ovarian dermoid cyst resulting in a gynecological and hormonal imbalance. The diagnosis was confirmed by subsequent related investigations and the patient has been getting symptomatic treatment.This case underscores the importance of a comprehensive differential diagnosis in patients presenting with related symptoms and highlights the value of a multidisciplinary approach for timely diagnosis, effective management, and improved patient outcomes. Despite advancements, the relationship between elevated prolactin levels and the pathophysiology of ovarian dermoid cysts remains unclear. The synchronous occurrence of these two conditions is rare and continues to pose a diagnostic and therapeutic challenge for clinicians.Publication Postpartum Cavernous Sinus Thrombosis Associated with Eclampsia and Gestational Diabetes Mellitus: A Case Report(Nepal Medical Association, 2025) Chitrakar, Shasank; Aryal, Saroj Babu; Shrestha, Tirtha ManAbstract Pregnancy is the pro-thrombotic state. The objective of this report is to highlight the rare occurance of postpartum cavernous sinus thrombosis associated with eclampsia and gestational diabetes mellitus, emphasizing its clinical presentation. A 25-year-old Muslim female came with the complaint of headache,post auricular and right parietal region on 8th day post-partum. She had a history of postpartum eclampsia and Gestational Diabetes Mellitus for which she was treated with magnesium sulfate and oral hypoglycaemic agents respectively. MRV showed a filling defect in right transverse sinus, sigmoid sinus, and internal jugular vein. She was then admitted to the ward and was treated with heparin and antibiotics. She was then discharged on oral rivaroxaban. As pregnancy is itself a state of hyper-coagulable state, there seems to be a significant thrombosis risk. Hence clinicians should be aware of the possible thrombotic disorder in the background of this vignette.