Browsing by Author "Birua, Shyama"
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Publication Clinico-Demographic Profile of Febrile Seizure and Its Association With Iron Deficiency(Nepal Paediatric Society (JNPS), 2019) Birua, Shyama; Sarkar, Suman; Bera, Aparajita; Khan, KalimuddinAbstract: Introduction: Febrile seizure (FS) is recognised as the most frequent type of seizure in children (age six months to five years). This observational study was conducted in our hospital to assess any possible association of febrile convulsion with iron deficiency anaemia (IDA) and to see the incidence of iron deficiency in six months to five years old children. Methods: Eighty eight Simple febrile seizure patients of age six months to five years fulfilled the inclusion criteria and were enrolled between April 2018–March 2019. A pre-designed proforma including detailed history, physical examinations, systemic examinations and relevant investigations were filled-up. Results: Eighty eight subjects with FS were studied. Occurrence of IDA was 67.04% among them. Age was significantly associated with haemoglobin (Hb%) (p-value = 0.000), severity of anaemia (p-value = 0.000), mean corpuscular volume (MCV) (p-value = 0.000), mean corpuscular haemoglobin (MCH) (p-value = 0.000), mean corpuscular haemoglobin concentration (MCHC) (p-value = 0.000) and serum ferritin (p-value = 0.000). However, no significant association between Hb% and gender was found (p-value = 0.890). Conclusions: Considering the clinico-demographic context of the present study and extent of anxiety and worries of parents of FS children, it is imperative to initiate FS prevention and control programme. Nearly two-third of study subjects had significant low serum ferritin indicating association of simple febrile seizure with IDA. However, prevalence of IDA as a risk factor for FS needs to be studied on adequate and representative sample so that iron supplementation could be started as an inbuilt strategy of simple febrile seizure management.Publication Study on Association of Serum Ferritin With Thyroid Profile And Oral Glucose Tolerance Test in Thalassemia Major Children(Nepal Paediatric Society (JNPS), 2020) Khan, Sudip; Saha, Sudip; Pal, Partha Pratim; Bera, Aparajita; Birua, ShyamaAbstract: Introduction: The free iron and haemosiderosis-induced damage of the endocrine glands cause endocrinopathies such as abnormal glucose tolerance and hypothyroidism in transfusion - dependent beta-thalassemia major patients. Our objective was to study the association of serum ferritin level with thyroid dysfunctions; abnormal blood glucose tolerance and to see if they appear in the earlier period of life. Methods: This cross-sectional study was done among thalassemia major children of two to 12 years in a tertiary care hospital, Kolkata, India. A pre-designed proforma was filled. Serum ferritin, fT4, TSH level, and oral glucose tolerance test (OGTT) were measured at presentation and noted in proforma. Results: A total of 80 thalassemic children were studied. Fiftieth percentile cut off value (1414 ng/ml) of serum ferritin was found to be significant with associated variables like normal fT4, TSH, and OGTT. Out of all study subjects, 39 (51.3%) of normal fT4, 39 (54.9%) of normal TSH and 39 (52.0%) of normal OGTT had ferritin < 50th percentile (P < 0.05). Nine (11.3%) children had abnormal thyroid profiles and five (6.3%) children had abnormal OGTT having ferritin > 2000 ng/ml. At a cut off value of ferritin level > 1414 ng/ml, fT4, TSH and OGTT showed significant abnormality (p < 0.05 with df 1). Conclusions: Ferritin is a good indirect marker to assess the risk of endocrine abnormality in thalassemic children. Frequent monitoring should be done once ferritin level crosses 1000 ng/ml. This will help in early detection and timely management of thalassemia related endocrinopathies.