NepMed Repository :: Browsing by Author "Chalise, Sanat"

Browsing by Author "Chalise, Sanat"

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Correlation between Iron Parameters and Platelet Parameters in Iron Deficiency Anemia
(Institute of Medicine, 2019) Chalise, Sanat; Acharya, Nishant; Pradhan, Sailesh B
ABSTRACT Introduction: Iron deficiency anemia is the most common type of anemia and is diagnosed by iron studies. Reactive thrombocytosis is usually seen in iron deficiency anemia. The objectives of the study is to correlate between iron parameters and platelet parameters in patient with iron deficiency anemia. Methods: This was a cross-sectional study done in Department of Pathology at Kathmandu Medical College, Sinamangal between December 2018 to May 2019. Blood samples of 81 iron deficiency anemia patients were analysed to determine iron parameters and platelet parameters. SPSS version 20 was used to analyse the data. Results: Thrombocytosis was seen in 62 (76.5%) patient with iron deficiency anemia. Platelet count was negatively correlated with serum iron, percentage saturation and platelet distribution width (p˂0.001, for all) while positive correlation was obtained between platelet count and plateletcrit (p<0.05). Plateletcrit showed negative correlation with serum iron (p˂0.001) and platelet distribution width (p<0.05) while positive correlation was obtained with mean platelet volume, total iron binding capacity and platelet (p<0.05, for all). There was negative correlation between mean platelet volume and platelet count (p<0.001). Positive correlation was obtained between mean platelet volume and plateletcrit (p<0.05). Correlation was not found between mean platelet volume and iron parameters (p>0.05). Platelet distribution width showed negative correlation with total iron binding capacity, platelet (p˂0.001, for both), plateletcrit (p<0.05). Conclusion: Thrombocytosis is more commonly observed as compared to thrombocytopenia in patient with iron deficiency anemia. Serum iron and percentage saturation are the most important parameters affecting the platelet count. Keywords: Iron deficiency anemia, platelet parameters, thrombocytosis
Diurnal Variability of Peak Expiratory Flow Rate in Healthy Adult Employees of a Medical College of Kathmandu
(Institute of Medicine, 2021) Khakurel, Gita; Gautam, Kalyan; Chalise, Sanat
ABSTRACT Introduction: Peak expiratory flow measurement is a simple measure of respiratory capacity to diagnose airflow obstruction and monitor treatment response in patients with pulmonary diseases. But there is wide diurnal variability in its values. The objectives of this study was to determine the diurnal variability of peak expiratory flow rate in healthy adults. Methods: This cross-sectional study was done in employees of Kathmandu Medical College, Duwakot between March to August 2020. A total of 74 subjects of 30-45 years were included in the study. After adequate training, subjects were asked to record their own peak expiratory flow five times a day by Mini-Wright peak flow meter. Diurnal variability was expressed as amplitude percent mean and standard deviation percent mean. Data analysis was done by student’s unpaired t-test and one-way ANOVA. Results: The mean peak expiratory flow rate (in L/min) were lowest in morning (male: 478.75±45.91; female: 362.86±20.51) followed by progressive rise throughout the day and highest at evening (male: 531.88 ±43.95; female: 415.71±20.97) with slight fall at bedtime (male: 486.88±46.38; female: 362.86±20.51). The difference in peak expiratory flow rate at different time periods was statistically significant in both males and females (p<0.001). The diurnal variability as calculated by amplitude percent mean and standard deviation percent mean were found to be significantly higher in females (p=0.001 and 0.004 respectively). Conclusion:There is a variation of peak expiratory flow rate recorded during different time points of the day in healthy adults. Keywords: Diurnal variation, peak expiratory flow rate, spirometry
Glomangiomyoma of Uncertain Malignant Potential in the Urinary Bladder: A Case Report Authors
(Nepal Medical Association, 2021) Chalise, Sanat; Jha, Abhimanyu; Neupane, Prakash Raj
Abstract: Glomus tumour typically occurs in subcutaneous tissue but rarely in the visceral organs. Most glomus tumours are benign but few atypical glomus tumours have been reported. Herein, we report a case of a 44-year-old male who presented with hematuria. Transurethral resection of bladder tumour was done. Microscopic examination showed nests and sheets of tumor around the blood vessels. Spindle cells resembling smooth muscle were also observed. An increase in mitosis was observed. These tumour cells show diffuse and strong cytoplasmic positivity for smooth muscle actin and negative for Pancytokeratin, Desmin, Synaptophysin, Chromogranin, S100, and Cluster of Differentiation 34. Ki-67 index was approximately 5%. To our knowledge, this is the first report of Glomangiomyoma of uncertain malignant potential in the urinary bladder which is considered as an unusual variant of atypical glomus tumor. This case emphasizes the importance of broad differential diagnosis which has to be considered in the urinary bladder mass.
Histopathologic Analysis of Gastrointestinal Tract Polypoidal Lesions in a Tertiary Care Centre
(Institute of Medicine, Tribhuvan University, 2024) Chalise, Sanat; Hirachan, Suspana; Pradhan, Sailesh
Abstract: Introduction Gastrointestinal tract polyps lesions are commonly encountered lesions in histopathological examination. It is necessary to examine these polyps and to determine its nature for the management of patient. Methods A descriptive cross-sectional study was done in the Pathology Department of Kathmandu Medical College from January 2023 to July 2023 after obtaining ethical clearance. The study included all gastrointestinal tract polyps or polypoidal lesions identified endoscopically or colonoscopically, biopsied, and received for histopathological analysis. Results Among 96 polyps examined, 58 (60.4%) were seen in males and 38 (39.6%) were seen in female. The age of the patients ranged from 15 to 89 years, with a mean age of 45 years. Most of the polypoidal lesions were less than 1 cm in size (76 cases, 79.1%). Colon (54 cases, 56.2%) was the most common site followed by the stomach (22 cases, 23.0%). Of the polypoidal lesions, 66(68.8%) were non-neoplastic polyps, while 30(31.2%) were neoplastic. Tubular adenoma with low-grade dysplasia was the most common polyp identified in the colon (17 cases, 17.8%). Hyperplastic polyps were the most common type overall (19 cases, 19.8%), stomach being the most frequent site (13 cases, 13.6%). Conclusion A wide range of histological types of polypoidal lesions were found in the gastrointestinal tract. The most frequent occurrence was in the colon, and the majority were non-neoplastic in nature.
Histopathological Study of Whipple’s Pancreaticoduodenectomy Specimens at Tertiary Care Center
(Institute of Medicine, Tribhuvan University, 2024) Chalise, Sanat; Hirachand, Suspana; Pradhan, Sailesh
Abstract: Introduction Whipple’s pancreaticoduodenectomy has become a widely used resection procedure for pancreatic head, periampullary, ampullary, and biliary tumors. This study was conducted to analyze the histopathological features of these tumors in pancreaticoduodenectomy specimen. Methods A descriptive study was carried out in the Pathology Department of Kathmandu Medical College Teaching Hospital. Pancreaticoduodenectomy specimens received were assessed for tumor location, histopathologic categorization, grading, lymphovascular and perineural invasion, margin status, and lymph node status. AJCC TNM staging was done. Results Out of 41 Whipple's pancreaticoduodenectomy cases, 35 (85.4%) were malignant and 6 (14.6%) were benign. The patients' ages ranged from 30 to 84 years, with a mean age of 58.3 years and a male to female ratio of 1.2:1. Adenocarcinoma was the most common malignant lesion (73.2%; n=30) frequently found in the intra-ampullary and periampullary regions (31.4%; n=11). The intestinal type of adenocarcinoma was the most common (42.8%; n=15), followed by the pancreaticobiliary type (34.3%; n=12). Most tumors were moderately differentiated (74.3%; n=26). Perineural invasion was frequently seen in intra-ampullary and periampullary carcinoma (81.8%; n=9). Lymphovascular invasion was frequently seen in intra-ampullary and periampullary carcinoma (81.8%; n=9). Most tumors were in the T3 stage (42.9%; n=15), and overall nodal metastasis (N1 and N2) was seen in 57.1% (n=20). Conclusion Adenocarcinoma was the commonest diagsosis in pancreaticoduodenectomy specimens of the intra-ampullary and periampullary region. Malignant lesions were more frequent than benign lesion in our study.
Prevalence of Thyroid Disorder in Pregnant Women Visiting a Tertiary Care Teaching Hospital: A Descriptive Cross-sectional Study
(Nepal Medical Association, 2021) Khakurel, Gita; Karki, Chandrima; Chalise, Sanat
Abstract: Introduction: The function of the thyroid gland is altered during pregnancy. Thyroid disorders during pregnancy are associated with serious maternal and fetal outcomes. Universal screening for thyroid disorders is recommended in the first trimester of pregnancy. This study aims to determine the prevalence of thyroid disorder during pregnancy in women attending a tertiary care hospital. Methods: A descriptive cross-sectional study was conducted in the Department of Obstetrics and Gynaecology of Kathmandu Medical College and Teaching Hospital from March 2020 to August 2020 after obtaining ethical approval from the Institutional Review committee with reference number 20032020. The pregnant women >18 years of age, irrespective of their gestational age and gravida status, were included in the study by convenience sampling method. The participants were screened by estimation of thyroid function test. Data were collected, and statistical analysis was done in Statistical Packages for Social Services version 20.0. Results: A total of 329 pregnant women were included in this study. The prevalence of thyroid disorders in the present study is 24.62 %. The most common thyroid disorder observed was subclinical hypothyroidism comprising 65 (19.75 %) cases followed by overt hypothyroidism 8 (2.43%) cases. Conclusions: There is a high prevalence of thyroid disorders during pregnancy in our settings. Timely screening of pregnant women helps in the early diagnosis and management of complications related to thyroid disorders.

Browsing by Author "Chalise, Sanat"

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