Browsing by Author "Chalise, Sanat"
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Publication Histopathologic Analysis of Gastrointestinal Tract Polypoidal Lesions in a Tertiary Care Centre(Institute of Medicine, Tribhuvan University, 2024) Chalise, Sanat; Hirachan, Suspana; Pradhan, SaileshAbstract: Introduction Gastrointestinal tract polyps lesions are commonly encountered lesions in histopathological examination. It is necessary to examine these polyps and to determine its nature for the management of patient. Methods A descriptive cross-sectional study was done in the Pathology Department of Kathmandu Medical College from January 2023 to July 2023 after obtaining ethical clearance. The study included all gastrointestinal tract polyps or polypoidal lesions identified endoscopically or colonoscopically, biopsied, and received for histopathological analysis. Results Among 96 polyps examined, 58 (60.4%) were seen in males and 38 (39.6%) were seen in female. The age of the patients ranged from 15 to 89 years, with a mean age of 45 years. Most of the polypoidal lesions were less than 1 cm in size (76 cases, 79.1%). Colon (54 cases, 56.2%) was the most common site followed by the stomach (22 cases, 23.0%). Of the polypoidal lesions, 66(68.8%) were non-neoplastic polyps, while 30(31.2%) were neoplastic. Tubular adenoma with low-grade dysplasia was the most common polyp identified in the colon (17 cases, 17.8%). Hyperplastic polyps were the most common type overall (19 cases, 19.8%), stomach being the most frequent site (13 cases, 13.6%). Conclusion A wide range of histological types of polypoidal lesions were found in the gastrointestinal tract. The most frequent occurrence was in the colon, and the majority were non-neoplastic in nature.Publication Histopathological Study of Whipple’s Pancreaticoduodenectomy Specimens at Tertiary Care Center(Institute of Medicine, Tribhuvan University, 2024) Chalise, Sanat; Hirachand, Suspana; Pradhan, SaileshAbstract: Introduction Whipple’s pancreaticoduodenectomy has become a widely used resection procedure for pancreatic head, periampullary, ampullary, and biliary tumors. This study was conducted to analyze the histopathological features of these tumors in pancreaticoduodenectomy specimen. Methods A descriptive study was carried out in the Pathology Department of Kathmandu Medical College Teaching Hospital. Pancreaticoduodenectomy specimens received were assessed for tumor location, histopathologic categorization, grading, lymphovascular and perineural invasion, margin status, and lymph node status. AJCC TNM staging was done. Results Out of 41 Whipple's pancreaticoduodenectomy cases, 35 (85.4%) were malignant and 6 (14.6%) were benign. The patients' ages ranged from 30 to 84 years, with a mean age of 58.3 years and a male to female ratio of 1.2:1. Adenocarcinoma was the most common malignant lesion (73.2%; n=30) frequently found in the intra-ampullary and periampullary regions (31.4%; n=11). The intestinal type of adenocarcinoma was the most common (42.8%; n=15), followed by the pancreaticobiliary type (34.3%; n=12). Most tumors were moderately differentiated (74.3%; n=26). Perineural invasion was frequently seen in intra-ampullary and periampullary carcinoma (81.8%; n=9). Lymphovascular invasion was frequently seen in intra-ampullary and periampullary carcinoma (81.8%; n=9). Most tumors were in the T3 stage (42.9%; n=15), and overall nodal metastasis (N1 and N2) was seen in 57.1% (n=20). Conclusion Adenocarcinoma was the commonest diagsosis in pancreaticoduodenectomy specimens of the intra-ampullary and periampullary region. Malignant lesions were more frequent than benign lesion in our study.