Browsing by Author "Chalise, Shiva Prasad Sharma"
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Publication Clinical Profiles of Neonates Born to COVID-19 Positive Mothers in a Tertiary Care Centre: A Descriptive Cross-sectional Study(Nepal Medical Association, 2021) Chalise, Shiva Prasad Sharma; Mishra, Santosh Kumar; Chalise, Bimal Sharma; Rai, Punam; Paudel, Subash; Kansakar, Prerana; Ojha, Anil RajAbstract: Introduction: Nepal is one of the countries which has been hit hard by the COVID-19 pandemic and has resulted in high morbidity and mortality across all age groups including neonates. There has been a paucity of studies regarding maternal to neonatal COVID-19 transmission and the published studies also have a poor sample size to reach any definite conclusion. Hence this study was carried out to see the clinical profiles of neonates born to COVID-19 mothers. Methods: It was a descriptive cross-sectional study. The study was conducted at a tertiary care centre over the period of one year from April 2020 to March 2021 after taking ethical clearance from the Institutional Review Committee with reference number drs2105211526. Convenient sampling was done. All neonates born to COVID-19 positive mothers who were diagnosed by a real-time polymerase chain reaction of the nasopharyngeal swab during the time of delivery were included in the study. Data analysis was done using Statistical Package for Social Sciences 20 using appropriate tools. Results: A total of 105 babies born to COVID-19 positive mothers who were tested for COVID-19 infection were included in the study. Ten (9.5%) (3.89-15.10 at 95% Confidence Interval) of neonates born to COVID-19 positive mothers were positive for the COVID-19 virus. All the neonates born to COVID-19 positive mothers were discharged home except one case who had other comorbidities. Fever was present in four (40%) of COVID-19 positive neonates. Conclusions: There is a possibility of vertical transmission of coronavirus in neonates although the outcome is favourable.Publication Postnatal Growth Pattern of VLBW Infants Admitted at Patan Hospital - A Prospective Observational Study(Perinatal Society of Nepal (PESON), 2024) Paudeal, Subash; Ojha, Anil Raj; Chalise, Shiva Prasad Sharma; Twanabasu, Sajal; Sharma, SubasAbstract: Introduction: Very low birth weight (VLBW) infants (birth weight < 1500 g) comprise about one-third of neonatal deaths. Regular growth monitoring of these infants helps in assessing their nutritional status and identifies those with inadequate weight gain. Studies on postnatal growth velocities in VLBW infants have not been published so far in Nepal. Hence, this study aimed to describe postnatal growth pattern of VLBW infants admitted at Patan Hospital. Methods: It is a prospective observational study on VLBW infants admitted at Patan Hospital between March 17, 2021 and March 16, 2022. Weight, length, and head circumference (HC) were recorded and plotted on Fenton growth chart regularly until discharge. Data was entered into Microsoft Excel and analysed with SPSS version 25. Results: Seventy-two VLBW infants were admitted during the study period. Fiftyseven infants survived till they regained their birth weights and were included in final analyses. The mean weight gain velocity calculated from birth until discharge was 10.72 ± 2.98 g / kg / d and that after regaining birth weight was 17.33 ± 4.67 g / kg / d. These infants gained their length and HC on an average of 1.21 cm / week and 0.79 cm / week respectively. The incidence of postnatal growth failure at the time of discharge was 61.40%. Conclusions: The growth velocities in our VLBW infants is comparable to the standard recommended intrauterine rates. A large multi-centre prospective study is recommended to validate findings of this study