Browsing by Author "Das, RN"
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Publication Could garlic be an useful adjuvant therapy in adriamycin heart failure?(Kathmandu University, 2006) Das, RN; Poudel, N50 year old suffering from breast carcinoma, treated with adriamycin developed heart failure with 22.82% ejection fraction. Added garlic pearl to routine anti-failure measures for 9 months to achieve 51.6% ejection fraction. Key word: Garlic pearl, antioxidants, ductal carcinoma of breast, adriamycin, cardiomyopathy.Publication Efficacy of Albendazole and Short-Course Prednisolone Treatment in Children with One or Two Ring-Enhancing Lesions of Neurocysticercosis: A Randomized Controlled Trial(Nepal Paediatric Society (JNPS), 2007) Swain, PK; Thapalial, A; Das, RN; Dhaliwal, MS; Subedi, KAbstract: Context: Neurocysticercosis is a endemic disease in Nepal causing social and financial burden on society and developmental problem in children. Aims: To determine the efficacy of albendazole plus oral prednisolone in children with 1 or 2 ring-enhancing lesions (by CT) on resolution of lesions and recurrence of seizure. Setting and Design: Randomized controlled open trial. Methods and Materials: Children with 1 or 2 ring-enhancing lesions < 20 mm in diameter on computed tomography scan, likely to have Neurocysticercosis, were assigned to treatment & control groups. Children assigned to the treatment group (n = 50) were given 2.0 mg/kg per day prednisolone orally for 5 days plus 15 mg/kg per day albendazole on third day for 28 days. Anti epileptic drugs were given to both groups {including Control group (n = 51)}. Statistical Analysis: The results were analysed with the use of Epi Info version 6.04 and Stata version;7 software. Results: The lesions resolved completely or partially in more children in the treated group compared with the control group (p = .04 & p = 0.03). The proportion of children who had seizures was significantly lower in the treated group compared with the control group at 6 months (10% versus 33%; p = .006) and 12 months (14% versus 38%; p = .003). Conclusion: Albendazole plus Prednisolone increased resolution of lesions on computed tomography scan and reduced the risk of subsequent recurrence of seizures among children with Neurocysticercosis.Publication Ping pong ball in the hefty heart: A case report(Kathmandu University, 2006) Das, RN; Goutam, NWe describe here a very unusual case of a large free floating left atrial thrombus due to critical mitral stenosis detected by incidental echocardiography, in whom peculiar symptoms and complications of ball thrombus were absent. The patent's only symptom was mild dyspnoea attributed to smoking. She had no syncope or arrhythmia induced embolic event. Owing to non-availability of cardiothoracic facility, she was given anticoagulant therapy which resulted in intracerebral haemorrhage and death. Key words: Ball thrombus, mitral valve disease, asymptomatic, anticoagulant therapy, intracerebral bleed.