Browsing by Author "Dhungana, Reechashree"
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Publication Histopathological Profile of Lung Cancer: A Single-Center Study from Nepal(Institute of Medicine, Tribhuvan University, 2025) Paudel, Bishal; Dhungana, Reechashree; Shrestha, Rakshya; Panthi, Bishal; Kharel, SanjeevAbstract: Introduction Lung cancer remains the leading cause of cancer-related mortality globally, accounting for approximately 18% of all cancer death. Despite the global prevalence of lung cancer, epidemiological data from Nepal remain limited. The study aims to bridge these gaps by investigating the histopathological characteristics of lung cancer in a cohort of patients from a tertiary care center in Nepal. Methods This is an observational cross-sectional study conducted at Tribhuvan University Teaching Hospital (TUTH) among lung cancer patients aged greater than 18 years of age from September 2024 to February, 2025. Descriptive statistics was used to summarize demographic and histopathological characteristics. Results A total of 107 lung cancer patients were included in our study. The male:female ratio was 1.3 in our study, while the mean age of the patients was 67 years and standard deviation is 11 years. Squamous cell carcinoma (48%) and Adenocarcinoma (46%) were the major histological subtypes while only 6% cases were Small-cell carcinomas. Conclusion This study analyzes the histopathological and the demographic profile of lung cancer diagnosed at a single tertiary center of Nepal. Non-small cell lung cancer is the most common histological diagnosis in this study. Broader study is needed to explore the clinical and molecular associations.Publication Impact of Incentive Spirometry in COPD Exacerbations: A Comparative Study(Institute of Medicine, Tribhuvan University, 2024) Paudel, Bishal; Panthi, Bishal; Shrestha, Rakshya; Karki, Onika; Dhungana, Reechashree; Yadav, Alisha; GC, Saroj; Neopane,ArpanaAbstract: Introduction: Chronic Obstructive Pulmonary Disease (COPD) is a major cause of morbidity and mortality in Nepal, with acute exacerbations (AECOPD) leading to severe complications. This study explores the impact of incentive spirometry (IS) on clinical outcomes, arterial blood gases and hospital stay in AECOPD patients. Methodology: This comparative study was conducted at a tertiary care center in Kathmandu, Nepal and involved 60 AECOPD patients, split into two groups: 30 receiving standard medical treatment (control) without IS and 30 using IS. Demographic and clinical information were recorded and key outcomes— arterial blood gases (ABGs), MMRC score, respiratory rate, oxygen saturation, and hospital stay—were measured after stabilization and at discharge. Statistical analysis used SPSS 22, with significance set at p<0.05. Results: Both groups showed significant improvement in MMRC and oxygen saturation(p<0.001). However, the IS group also demonstrated a significant reduction in respiratory rate (26.73±2.52 to 21.07±2.11, p<0.001), unlike the control group (27.3±2.3 to 26.80±2.37, p=0.12) and had a shorter hospital stay (5.87±1.36 days vs. 8.56±1.99 days, p<0.001). The IS group also demonstrated significant improvements in ABG parameters from admission to discharge: pH (7.35±0.087 to 7.42±0.054, p<0.001), pCO2 (62.76±9.55 to 43.88±6.62, p<0.001), and pO2 (62.76±9.55 to 78.88±6.97, p<0.001), while the control group did not. Conclusion: Incentive spirometry proved superior to medical treatment alone by significantly improving ABGs, respiratory rate and reducing hospital stay in AECOPD patients. These findings support IS as a cost-effective tool in AECOPD management, particularly in resource-limited settings like Nepal. Further research is recommended to validate these results.Publication Pattern of Blood Products Consumption in a Teaching Hospital(Nepal Health Research Council, 2024) Shrestha, Lava; Gurung, Numaya; Mahotra, Narayan Bahadur; Pradhan, Sait; Ghimire, Ananda; Pokhrel, Kailash Mani; Khanal, Kapil; Dhungana, Reechashree; Gautam, Naveen; Kandel, Sabita; Chaudhary, SonamBackground: Blood transfusions are lifesaving, but resource limitations and inadequate utilization patterns pose challenges in low- and middle-income countries. In Nepal, detailed analyses of blood use practices, are needed to inform resource allocation and policy decisions. The objective of this study was to study the overall and component-specific use, explore temporal trends in utilization of blood and blood products. Methods: We conducted an observational study analyzing data from Blood Bank of Tribhuvan University Teaching Hospital (TUTH), a tertiary hospital (January 1st - December 31st, 2019). Data included patient demographics, blood groups, blood products requested and transfused, and facility type. Data analysis was conducted with SPSS v20. Results: Patients from TUTH had substantially higher blood product requests, requesting 25,716 units compared to only 1855 units across other centers combined. Blood groups A positive (8089, 31.4%) and and O positive (7851, 30.6%) were the most requested blood groups. Whole blood (11358, 44.2%) and packed red blood cells (9565, 37.2%) were most frequently requested. We observed monthly fluctuations in demand with peak of 2742 requests in December with a trough in June (1947 units). Notably, only approximately 46% of blood products requested from patients admitted to TUTH were ultimately transfused. Conclusions: Whole blood and packed red blood cells were the most frequently requested blood products. Eventhough whole blood was the most frequently requested blood product, the most transfused one was packed red cells. Peak demand was observed in December. Our study provides valuable insights into blood utilization patterns, underscoring the need for specific strategies to improve blood transfusion management practices. Keywords: Blood banking; blood transfusion; blood utilization; LMICs. Nepal.