Browsing by Author "Dhungel, S"
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Publication Can homemade alcohol (raksi) be useful for preserving dead bodies? An experiment on wistar albino rats(Kathmandu University, 2007) Dhungel, S; Maskey, D; Jha, CB; Bhattacharya, S; Paudel, BH; Shrestha, RNIntroduction: Embalming is the through disinfection and art of preserving bodies after death using chemical substances. It keeps a body life like in appearance during the time it lies in a state prior to funeral. Objective: This study was undertaken to investigate the effectiveness of Raksi in sacrificed rats in arresting postmortem changes and establishing scientific fact whether Raksi can be an alternative to standard embalming constituent if it is not available. Material and methods: 50 albino rats were systematically randomized into control and experiment groups. Raksi and distilled water were injected for embalming purpose intraventricularly in experiment and control groups of rats respectively and kept for 48 to 96 hours for observation for postmortem changes. Result: Observations made at 48 and 72 hours of embalming revealed that Raksi can arrest postmortem changes in the rats up to 72 hours (3 rd day) successfully in the experimental group whereas moderate to severe postmortem changes were seen in the control group. The experimental group showed mild degree of putrefactive changes, liberation of gases and liquefaction of tissues only at 96 hours (4th day) of embalming. Discussion: The Raksi used in this experiment contained 34% of alcohol, which was determined by an alcohol hydrometer. Experiment clearly demonstrated from its result that raksi can be utilised temporarily for embalming since it contains alcohol and has preservative, bactericidal and disinfectant properties. Conclusion: It is concluded from the study that this knowledge if applied to dead human subjects, may preserve dead bodies temporarily allowing delayed funeral. Key words: Rat, Embalming, Homemade alcohol, Raksi, FuneralPublication Effect of maternal deprivation on growth of wistar rats in preweaning period(Kathmandu University, 2007) Dhungel, SObjective: The objective of this study was to observe the effect of maternal deprivation on somatic growth of wistar rat pups viz. Body weight, nose-rump length, tail length and head length. Materials and method: 5 days old 50 rat pups were studied dividing equally into control and experimental groups. Experimental group (N=25) of rats were maternally deprived 1-4 hours twice daily till the weaning period. Body weight and measurement of body parts were recorded at 4 days interval till 29th day. Recorded parameters were statistically analysed. Result: The result of this study revealed that maternal deprivation stress produces significant effect in the body weight, nose-rump length and tail length from D9 till the study period whereas head length insignificantly affected. Conclusion: MD stress has profound effects on somatic growth and found irreversible even after withdrawal for a period of 8 days. Key words: Maternal deprivation, stress, body weight, somatic growth, preweaning periodPublication When left ventricular failure complicates chronic obstructive pulmonary disease: Hypoxia plays the major role(Kathmandu University, 2008) Paudel, B; Dhungel, S; Paudel, K; Pandru, K; Paudel, RAbstract Introduction: As the chronic obstructive pulmonary disease (COPD) progress, is usually accompanied by involvement of the both left ventricle (LV) and right ventricle (RV), and their systolic and diastolic function. Signs and symptoms of LV failure can be difficult to distinguish from those of COPD. Objective: The study was carried out to determine the prevalence of LV systolic dysfunction in the COPD patients and to assess the possible risk factor behind such development. Material and Methods: It is a prospective study of 60 cases of COPD patients with or without cor-pulmonale attending Manipal Teaching Hospital. Results: The prevalence of LV systolic dysfunction was found to be 26.7%, and the findings directly correlate with the severity of COPD i.e., the more the severity of the lung disease more the probability for the incidence of LV systolic dysfunction. These data are in support of the hypothesis that hypoxia and the excess accumulation of toxic metabolic products like lactic acid, significant right-to-left shunting through the bronchial circulation explains the diminished LV ejection fraction in severe COPD patients. Conclusion: Routine echocardiography investigation of the severe COPD patients is required for assessing the status of LV function and to rule out the possible association of LV systolic dysfunction. Key words: Chronic obstructive pulmonary disease, Cor-pulmonale, Hypoxia, LV systolic dysfunction