Browsing by Author "Gautam, Narayan"
Now showing 1 - 3 of 3
Results Per Page
Sort Options
Publication Association Between Serum Uric Acid Level and Psoriasis: A Case Control Study(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2021) Sayami, Aruna; Gupta, Aatmaram; Gautam, NarayanAbstract: Introduction: Psoriasis is a common, chronic, inflammatory and proliferative condition of the skin, associated with various disorders including metabolic syndrome. High serum uric acid levels are also associated with metabolic syndrome. Hyperuricemia is associated with psoriasis and psoriatic arthritis. Objectives: To find out the association of serum uric acid with psoriasis. Materials and Method: It was a case-control study including 104 patients, among them 52 were psoriatic patients (case) and 52 had disease other than psoriasis (control) after matching for age and sex. The study was conducted at Department of Dermatology, Universal College of Medical Science, from January- December 2017. Clinical examination and proforma documentation including patient details, laboratory values of serum uric acid level, Psoriasis Area and Severity Index score were studied. Results: Mean SUA in psoriasis patients was 4.70±1.37 mg/dl in female, 5.57±1.18 mg/dl in male whereas 4.85±0.74 mg/dl in female and 4.34 ± 0.98 mg/dl in male respectively in control group (p=0.002). Six (18.88%) male and three (15.78%) female patients with psoriasis had higher serum uric acid value whereas only four (3.84%) patient had higherserum uric acid value in control group (p=0.012). There was association between serum uric acid and psoriasis. Conclusion: Our study concludes that serum uric acid level is increased in psoriasis patients when compared with controls. Monitoring of psoriatic patients for high serum uric acid levels during treatment and follow up should be done to prevent the its deleterious effect on psoriasis. Keywords: hyperuricemia, psoriasis, psoriatic arthritis, serum uric acid.Publication Association between Serum Zinc Level and Cutaneous Viral Warts: A Case Control Study(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2019) Ranjit, Annu; Rajbhandari, Sudharshan Lal; Gautam, Narayan; Poudyal, YogeshAbstract: Introduction: Cutaneous viral warts are one of the common skin disorders in general population which can affect any age group and any gender in any country and pose a significant health problem. A possible association with zinc has been suggested in previous studies. Zinc is known to be required for efficient functioning of immune system. Objective: To find out the association between serum zinc level and cutaneous viral warts. Materials and methods: In this case-control study, total of hundred patients were enrolled. Among them 50 (males – 27, females – 23) with cutaneous viral warts were taken as cases and 50 (males – 25, females – 25) healthy individuals were taken as controls after matching the age and sex. The patients were selected from Dermatology outpatient Department of Universal College of Medical Sciences Teaching Hospital, Bhairahawa, Nepal. The serum zinc level was measured using spectrophotometry principle. Results: The mean serum zinc level in the cases and controls were 80.50±37.24 mg/dl and 104.31±25.31 mg/dl respectively. Significant difference in serum zinc level was observed between cases and controls (p=0.0001). There was a strong association between low serum zinc level and cutaneous viral warts (OR=7.37; 95% CI=1.98 – 27.31; p=0.0028). Conclusion: Serum zinc level in patients with cutaneous viral warts was significantly low as compared to the healthy controls. Keywords: Immune system, micronutrients, papillomaviridae, warts, zincPublication Hypovitaminosis D among Blood Samples of Patients Presenting to the Department of Biochemistry of a Tertiary Care Center(Nepal Medical Association, 2023) Tamang, Binaya; Pokhrel, Buddhi Raj; Shrestha, Jharana; Gautam, Narayan; Sharma, Binit KumarAbstract Introduction: Hypovitaminosis D is a global public health problem affecting approximately one billion people, with a particularly high prevalence in South Asia. Several hospital-based studies from Nepal show a high prevalence of hypovitaminosis D. However, large-scale community-based studies are lacking. The aim of the study was to find out the prevalence of hypovitaminosis D among blood samples of patients presenting to the Department of Biochemistry of a tertiary care centre. Methods: A descriptive cross-sectional study was conducted among blood samples of patients presenting to the Department of Biochemistry of a tertiary care centre from 3 November 2022 to 30 April 2023 after obtaining ethical approval from the Institutional Review Committee (Reference number: 136/22). Patients of all age groups and genders who were sent for the evaluation of Vitamin D at the laboratory were included. A convenience sampling technique was used. The point estimate was calculated at a 95% Confidence Interval. Results: Out of 376 patients, hypovitaminosis was seen in 274 (72.87%) (68.38-77.36, 95% Confidence Interval). Vitamin D insufficiency was present in 252 (91.97%) and vitamin D deficiency was present in 22 (8.03%) participants. Conclusions: The prevalence of hypovitaminosis D was found to be higher than other studies done in similar settings.