Browsing by Author "Karki, Anil Bikram"
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Publication Health Beyond Health: Insights and Implications from the Fourth National Health Summit of Nepal, 2024(Nepal Medical Association, 2025) Jha, Jay Bhushan; Karki, Anil Bikram; Tiwari, SanjeebAbstract The 4th National Health Summit in Nepal, themed "Health Beyond Health," explored the interconnections between health and social, economic, and environmental factors, emphasizing the role of health as a driver of national progress. The summit brought together diverse stakeholders, including policymakers, healthcare professionals, researchers, and civil society leaders, to address transformative health strategies. With subthemes ranging from universal health coverage to the impact of climate change on health, the event highlighted the importance of a holistic, intersectoral approach to health system strengthening. This viewpoint reflects on the summit's outcomes, its inclusive and participatory approach, and the critical need for translating recommendations into actionable strategies to achieve health equity and resilience for Nepal's future.Publication Role of Prophylactics Antibiotics in Clean Head and Neck Surgery in a Tertiary Care Center of Nepal: A Prospective Comparative Study(Nepal Health Research Council, 2024) Paudel, Deepak; Karki, Anil Bikram; Shrestha, AmodBackground: Surgical site infections are well recognized complications of any surgical procedures. In head and neck surgeries, prophylactic antibiotics are commonly used to prevent Surgical site infections, in contaminated and clean contaminated procedures. Guidelines advised against routine antibiotics use in clean surgeries, but in our setting, non-compliance is frequent, resulting excessive antibiotics use. Objective of the study was to compare the Surgical site infections rate between prophylactics antibiotics group and no antibiotics group in clean head and neck surgery. Methods: It was a prospective comparative study conducted at a tertiary care centre of eastern Nepal. Patients were assigned to two groups, one receiving prophylactic antibiotics and another receiving no antibiotics. Results: Out of 131 patients, 66 received prophylactic antibiotics and 65 did not. Thyroidectomy was the most common surgery. The surgical site infection rate was 6.06% in antibiotic group and 7.69% in no antibiotic group, the difference was not significant (p=0.744). The risk reduction of surgical site infection with use of antibiotics was 0.0163 and number need to treat was calculated to be 61.35 About 3% of the patients who were administered antibiotics experienced adverse drug reactions. Factors, such as gender, amount of blood loss, smoking, placement of drains had no significant impact on Surgical site infections rate. Conclusions: Prophylactics antibiotics does not offer substantial advantages in preventing surgical site infections and are not advised for such procedures. Moreover, their use increases the financial burden and risk of adverse drug reactions to the patients. Keywords: Adverse drug reaction; antibiotics; surgical site infections; thyroidectomy.Publication Validation of Nepali Version of the University of Washington Quality of Life Questionnaire for Head and Neck Cancer Patients.(Nepal Medical Association, 2025) Paudel, Deepak; Karki, Anil Bikram; Parajuli, BibasAbstract Introduction: Quality of Life (QoL) encompasses physical, functional, emotional, and social wellbeing, often assessed via self-reported questionnaires. The University of Washington Quality of Life (UW-QOL) instrument, designed for Head and Neck Cancer (HNC) patients, is a validated, concise, and practical tool widely used in clinical settings. The objective of the study was to translate and assess the content and face validity of the Nepali version of the University of Washington Quality of Life Questionnaire (UWQOLv4.1-N) and evaluate its psychometric properties in HNC patients. Methods: Quality of Life (QoL) encompasses physical, functional, emotional, and social well-being, often assessed via self-reported questionnaires. The University of Washington Quality of Life (UWQOL) instrument, designed for Head and Neck Cancer (HNC) patients, is a validated, concise, and practical tool widely used in clinical settings. The objective of the study was to translate and assess the content and face validity of the Nepali version of the University of Washington Quality of Life Questionnaire (UWQOLv4.1-N) and evaluate its psychometric properties in HNC patients. Results: The UWQOLv4.1-N demonstrated strong internal consistency (Cronbach’s α = 0.87), and excellent test-retest reliability and stability (r = 0.93). A strong correlation (r > 0.50) was observed between similar domains of the UWQOL and EORTC QLQ-C30 and HN355. UWQOL composite scores demonstrated a strong correlation with all domains of global questions at admission, as well as after 3 and 6 months of treatment (p< 0.01). Conclusions: The Nepali version of UWQOLv4.1-N is a valid and reliable instrument to assess the QoL of HNC patients in Nepal.