Browsing by Author "Karki, Asmita"
Now showing 1 - 3 of 3
Results Per Page
Sort Options
Publication A Rare Case of Crigler-Najjar Syndrome Type 2(Nepal Health Research Council, 2025) Shrestha, Anil Kumar; Sherpa, Sangay Chultim; Karki, Asmita; Agrawal, Sumit; Paudel, Deepak RajCrigler–Najjar Syndrome Type 2 (CNS2) is a rare autosomal recessive disorder characterized by unconjugated hyperbilirubinemia due to partial deficiency of the enzyme uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1). We present a case of a 13-month-old male admitted to Kanti Children’s Hospital with persistent jaundice since birth. Diagnostic evaluation accompanied by gene sequencing confirmed CNS2 and the patient was effectively managed with orally administered phenobarbitone. CNS2 can be distinguished from other potential causes of unconjugated hyperbilirubinemia based on bilirubin concentration and the affected patient’s response to phenobarbitone. Genetic counselling is essential for the recognition and prevention of severe hyperbilirubinemia which, in the absence of timely medical intervention, may lead to neurotoxicity. Keywords: Case report; crigler-Najjar syndrome; genetic counseling; phenobarbitone; unconjugated hyperbilirubinemia.Publication Arthralgia among Patients with COVID-19 Infection Admitted to the Department of Medicine of a Tertiary Care centre: A Descriptive Cross-sectional Study(Nepal Medical Association, 2023) Risal, Ujjwol Prasad; Ghimire, Mrikchhya; Karki, Asmita; Shahi, Nahakul; Pandey, SuraviAbstract Introduction: COVID-19 is a global pandemic that has affected millions of people worldwide. It predominantly affects the respiratory tract causing various respiratory symptoms. It also causes various musculoskeletal symptoms in the form of arthralgia and myalgia which may be incapacitating for some patients. The objective of this study was to find out the prevalence of arthralgia among patients with COVID-19 infection admitted to the Department of Medicine. Methods: This descriptive cross-sectional study was carried out in the Department of Internal Medicine of a tertiary care centre. Data from March 2020 to May 2021 were collected between 2 December 2021 and 20 December 2021 from the hospital records. Ethical approval was obtained from the Ethical Review Board (Reference number: 1312). All patients who were admitted with the diagnosis of COVID-19 infection based on positive Reverse Transcriptase-Polymerase Chain Reaction for COVID-19 were included in the study. Convenience sampling method was used. Point estimate and 95% confidence interval were calculated. Results: Among 929 patients included in the study, the prevalence of arthralgia was found to be 106 (11.41%) (10.30-12.51, 95% Confidence Interval). The mean age of these patients was 52.81±17.46 years. Conclusions: The prevalence of arthralgia in COVID-19-infected patients was similar to other similar studies done in similar settings.Publication Correlation of Cervical Pap Smear with Cervical Biopsy in Lesions of Cervix(Institute of Medicine, Tribhuvan University, 2024) Tiwari, Archana; Khanal, Anupa; Sapkota, Pratima; Karki, AsmitaAbstract: Introduction Cervical cancer is the leading cause of mortality for women in underdeveloped nations and the 4th leading cause globally. Pap smears are non-invasive method, but are unable to pinpoint their location. However, cervical biopsies are an invasive but gold standard procedure. Methods An analysis of all pap smears obtained during a one-year period, from April 14, 2022 to April 12, 2023 was carried out in the Department of Pathology, LMC, Palpa. But only the cases that had undergone both pap smear and cervical biopsy were compared. Only 64 of the 337 pap smears that were obtained for cytological analysis also had a biopsy. Results Out of 64 pap smear, 32.81% had normal cytology, 25% had ASC-US, 4.68% had atypical glandular cells, and 9.37% had HSIL. The most pap smears were done on people between the ages of 31 and 40. In 64 biopsies, 23 (35.93%) had HSIL, 20 (31.25%) had LSIL, and 7 (10.93%) had chronic cervicitis, according to the histological diagnosis of biopsies. Four individuals had a cancer diagnosis, including two (3.12%) squamous cell carcinomas and two (3.12%) adenocarcinomas. The Pap smear showed a sensitivity of 25.92%, specificity of 94.59%, PPV of 77.77%, NPV of 63.63%, and a diagnostic accuracy of 65.62%. Conclusion The Pap smear test, had poor sensitivity but good specificity in detecting premalignant and malignant cervical abnormalities. Pap smear is a noninvasive method; however, cervical biopsy is a gold standard but invasive technique.