Browsing by Author "Karki, Shovana"
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Publication Epithelioid Gastrointestinal Stromal Tumor of Duodenum Mimicking Adenocarcinoma: A Case Report Authors(Nepal Medical Association, 2021) Tiwari, Sansar Babu; Karki, ShovanaAbstract: Gastrointestinal stromal tumor is a mesenchymal tumor of gastro-intestinal tract. This epithelioid type gastrointestinal stromal tumor seen in a 22-year-old male with epigastric pain as a presenting symptom had morphological resemblance to carcinoma. However, the immunohistochemistry profile with CD117 and DOG 1 positivity, combined with AE1/AE3 positivity confirmed the tumor as gastrointestinal stromal tumor. Approximately 95% of the patients with gastrointestinal stromal tumor show CD117 immunoreactivity. The treatment approach of CD117 positivity in gastrointestinal stromal tumor has therapeutic benefit with tyrosine kinase inhibitors. Preoperative Imatinib therapy with complete excision can decrease the disease recurrence. Histopathological examination with immunohistochemical studies help to reach the definite diagnosis.Publication Histopathological Findings of Pancreaticoduodenectomy Specimens in a Tertiary Care Hospital in Nepal(Institute of Medicine, 2021) Karki, Shovana; Shrestha, Sonafi; Tiwari, Sansar B; Lakhey, Paleswan JoshiABSTRACT Introduction: Among the gastrointestinal malignancies, 5% of the tumors comprise peri-ampullary carcinomas. Adenocarcinoma is the commonest malignancy in the peri-ampullary region. The important histopathological prognostic factors are tumor size, location, extension, resected marginal status, lymphovascular (LVI) and perineural invasion (PNI) and lymph nodal status. This study was conducted to analyze the lesions and to describe the associated histopathological parameters. Methods: This study was carried out in the Department of Pathology, TUTH, Kathmandu, includes pancreatico-duodenectomy specimens submitted from April 2016 to September 2020. The related details were obtained from the archives of reports in the Department. Statistical analysis was performed using IBM SPSS v26. Results: Among 111 specimens, 100 (90%) malignant lesions, 10 (9.1%) benign lesions and 1(0.9%) pre-malignant lesions were seen. M:F ratio was 1.2:1 with mean age 55.5 years. Ampulla was the most common site of malignancy (61%) and adenocarcinoma was the commonest histological type. Chronic pancreatitis (4.5%) accounted for most of the benign lesions. Ampullary and pancreatic malignancies were detected in T2 stage, 55.7% and 77.8% respectively. LVI was seen in 61% and PNI in 72% of pancreatic malignancies. Positive resected margin was seen in 6% of malignancies. SMA was the most common positive margin. Conclusion: Pancreatico-duodenectomy was performed mostly for adenocarcinomas of ampulla. Pancreatic tumors were common in the older age group and they presented with LVI and PNI and at a higher T and N status as compared to ampullary or duodenal tumors. Keywords: Lymphovascular invasion, margins, perineural invasion, pancreatico-duodenectomy specimen