Browsing by Author "Lamichhane, Pratik"
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Publication Potential Drug-drug Interaction among the Patients Admitted in Intensive Care Units of a Tertiary Care Centre: A Descriptive Cross-sectional Study(Nepal Medical Association, 2022) Ghimire, Rakesh; Prasad, Pravin; Parajuli, Subigya; Basnet, Rabin; Lamichhane, Pratik; Poudel, Nirmal; Shrestha, Pramesh Sunder; Kharel, Shristi; Pokharel, Akritee; Mudvari, AnishAbstract Introduction: Drug interactions are one of the major contributors to increase hospital stay, inflate health care expenses, and cause serious adverse events and end-organ damage. Patients admitted to the intensive care unit are already critically sick and are at greater risk of these adverse outcomes. The study aimed to find out the prevalence of potential drug-drug interactions in the Intensive Care Units of a tertiary care centre. Methods: A descriptive cross-sectional study was conducted among the patients admitted in the Intensive Care Unit of a tertiary care hospital from April-June 2019. Ethical approval was taken from the Institutional Review Board at the institute (Reference number: 399). Convenience sampling method was used. Data was collected using proforma and potential drug-drug interactions were identified using Lexicomp® drug-interactions version 1.1 (Wolters Kluwer). All the drug interactions identified were classified and the severity scale of interactions was also defined. Statistical Package for the Social Sciences version 17.0 was used for data analysis. Point estimate at 95% Confidence Interval was calculated along with frequency, percentage, mean, standard deviation, and mode. Results: Out of 101 patients, the prevalence of the drug-drug interaction was found to be 90 (89.11%) (83.04-95.18 at 95% Confidence Interval). A total of 490 drug-drug interactions were identified. In severity scale, it was seen that 311 (63.46%) were of moderate severity and 303 (61.83%) of drug interactions were categorised as category C in risk rating. Conclusions: Prevalence of potential drug-drug interactions was higher compared to similar published literature. The most common drug with potential interaction was fentanyl and among pairs was fentanyl plus paracetamol.Publication Potential Drug-drug Interactions among Hospital Discharge Prescriptions in a Tertiary Care Centre of Nepal: A Descriptive Cross-sectional Study Authors(Nepal Medical Association, 2022) Bhandari, Bijay; Lamichhane, Pratik; Yadav, Dipendra; Bajracharya, Sangha RatnaAbstract: Introduction: In our setup, potential drug-drug interactions are overlooked in routine clinical practice. In general, most of the discharges are handwritten in the developing world, and the discharge prescriptions are not checked with the database for potential drug-drug interactions checker. This study aimed to determine the prevalence of potential drug-drug interactions in the prescribed drugs in clinical practice in a tertiary care centre of Nepal. Methods: A descriptive cross-sectional study was conducted in a tertiary care center from October 2019 to December 2019. Ethical approval was taken from the Institutional Review Committee (Reference number: 394(6-11)E2/075/76). Through simple random sampling, the data about drug prescription was collected from the patient discharge records of the Department of Internal Medicine. The potential drug interactions were checked by using Lexicomp® drug interactions. Data was analysed using Statistical Package for the Social Sciences version 20.0. Point estimate at 95% Confidence Interval was calculated along with frequency, percentage, mean, standard deviation and mode. Results: Among 382 discharge prescriptions, the prevalence of potential drug-drug interactions was 299 (78.3%) (74.1-82.4 at 95% Confidence Interval). A total of 1519 drug interactions with a mean of 5.08±3.89 drug interactions per prescription was identified. The major, moderate and minor drug-drug interactions according to the severity were found to be 163 (10.7%), 1162 (76.5%), and 178 (11.7%) respectively. Conclusions: The prevalence of potential drug-drug interactions is high among the patients on discharge compared to similar studies. Use of drug-drug interactions checker databases before discharge with computer-based discharge prescriptions is recommended.Publication Ultrasonography Findings of Testicular Tuberculosis in Nepalese Patients: A Case Series(Nepal Medical Association, 2024) Thapa, Madan; Kafle, Sushmit; Lamichhane, Pratik; Thapa, SureshAbstract Extrapulmonary tuberculosis constitutes about 20% of all cases of tuberculosis. It involves organs other than the lungs, such as lymph nodes, the genitourinary tract, abdomen, skin, joints and bones, and meninges. Tuberculosis of the testis is a rare disease. The diagnosis of testicular tuberculosis could be confused with testicular cancer, sarcoidosis or metastases. Herein, we describe the ultrasonography of five patients with testicular tuberculosis. This case series highlights the importance of ultrasonography in the diagnosis of rare form of extra pulmonary tuberculosis.