Repository logo
Government of Nepal
NEPAL HEALTH RESEARCH COUNCIL
Repository logo
  • Log In
    New user? Click here to register. Have you forgotten your password?
Repository logo
Government of Nepal
NEPAL HEALTH RESEARCH COUNCIL
Repository logo
  • Log In
    New user? Click here to register. Have you forgotten your password?
  1. Home
  2. Browse by Author

Browsing by Author "Lamsal, M"

Now showing 1 - 2 of 2
Results Per Page
Sort Options
  • Loading...
    Thumbnail Image
    Publication
    Altered serum levels of thyroxine, triiodothyroinine and thyroid stimulating hormone in patients with depression
    (Kathmandu University, 2007) Das, BKL; Baral, N; Shyangwa, PM; Toora, BD; Lamsal, M
    Objective: To assess serum level of Thyroxine (T4), Triiodothyronine(T3) and thyroid stimulating hormone(TSH) in patient with depression. Methods: Thirty one clinically diagnosed depressed patients and equal number of healthy, age and sex matched control subjects were included in this study. Ham-D scale was used to classify the degree of depression into mild, moderate and severe grades. The biochemical parameters (T3, T4 and TSH) were estimated using commercially available kits. The data were analyzed by using (SPSS-10 software), one way ANOVA and χ2 test. Result: Female depressed (n = 17) cases outnumber the male depressed cases. The distributions of patients in mild, moderate and severe categories were similar. The T3 and T4 level were found to be significantly raised in the moderate depression as compared to the healthy controls. ANOVA with multiple comparisons testing among the patient group showed a significant high TSH level (F> 3.17) at 5% level of significance. A total of six depressive patients were found to have thyroid abnormalities. Conclusion: This study therefore points towards presence of thyroid dysfunction among the depressive which most often characterized as a “Lower Thyroid Syndrome”. Thus inclusion of thyroid screening test among depressive patients may be helpful in proper management of cases.
  • Loading...
    Thumbnail Image
    Publication
    Subclinical hypothyroidism in eastern Nepal: A hospital based study
    (Kathmandu University, 2010) Rohil, V; Mishra, AK; Shrewastwa, MK; Mehta, KD; Lamsal, M; Baral, N; Majhi, S
    Abstract Background: Subclinical hypothyroidism itself is associated with serious complications and also there is a known risk of subclinical hypothyroidism patients getting converted into overt disease. Objectives: The objective of the present study was to find out the prevalence of subclinical hypothyroidism in the suspected cases i.e. amongst the cases attending the thyroid laboratory at B.P. Koirala Institute of Health Sciences, Dharan, Nepal. Materials and methods: It was a retrospective cross sectional study. Data of the free T3, free T4 and TSH estimations of the year 2007 of the Thyroid lab at BPKIHS, Dharan, Nepal was analyzed. ELISA based free T3, free T4 and TSH tests in the serum had been performed in all the cases. Results: Total cases were 1714 including 24.446% males and 75.554% females. Cases with raised TSH levels were 26.021%, cases with normal TSH levels were 54.66% and cases with low TSH levels were 19.316%. Total 350 cases (20.42 %) had subclinical hypothyroid dysfunction which includes 84 (4.901 %) males and 266 (15.519%) females. And the maximum percentage of cases in either gender was between the age groups 20 -59 years. Conclusion: The prevalence of subclinical thyroid hypothyroidism amongst the suspected cases was 20.42 % which is much higher compared to the other parts of the world. The highest percentage was found in the female age group 20 – 59 years. The routine screening of the whole population is not cost effective and on the basis of the present study it is suggested that there may be routine screening of the selected populations, especially women between 20 to 59 years of age in Nepal region. The preferred screening method advised is a sensitive ELISA based TSH test. Key words: Subclinical hypothyroidism

Connect with us

Nepal Health Research Council © 2023
Ramshah Path, Kathmandu Nepal P.O.Box 7626