Browsing by Author "Marahatta, S"
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Publication Alopecia Areata and Thyroid Dysfunction Association- A Study from Eastern Nepal(Kathmandu University, 2018) Marahatta, S; Agrawal, S; Mehata, KDABSTRACT Background Alopecia areata (AA) is one of the non-scarring alopecia. Its etiology has not been well established till date. The most convincing hypothesis is autoimmune process for its causation. Amongst all, most frequent association was found with thyroid disorder. Objective To study the association of thyroid dysfunction in patients with alopecia areata. Method All patients of alopecia areata attending dermatology outpatient department and currently not receiving any treatment for alopecia areata were enrolled in the study. Relevant history and examination findings were recorded in the preset pro-forma. All of them were subjected for thyroid function test by chemiluminescence microparticle immunoassay method. Then thyroid function test of cases was compared with that of equal number of age and sex matched healthy controls. Result A total of 75 patients were enrolled in both case and control groups. Mean age of case and control groups were 29.40±9.90 and 28.96±9.89 years respectively (P=0.786). Median Severity of Alopecia Tool score was 2.47 (IQR=0.96-5.79). Prevalence of thyroid disorder was significantly higher in alopecia areata group (17.3%) as compared to the control group (1.3%) (P=0.001). Likewise, in individuals with abnormal thyroid function, alopecia areata disease severity grade and median severity of alopecia tool (SALT) score was higher as compared to those with normal thyroid function. Conclusion We found a significant association between alopecia areata and thyroid dysfunction. Hence thyroid function evaluation must be considered in individuals with alopecia areata. However, further studies with larger sample size are recommended before its generalization. KEY WORDS Alopecia areata, Severity of alopecia tool score, Thyroid function testPublication Hirsutism and Quality of Life of Women in Tertiary Care Center in Eastern Nepal(Kathmandu University, 2022) Maharjan, J; Agrawal, S; Marahatta, SABSTRACT Background Hirsutism is excess terminal hair growth in women at androgen-dependent sites of the body and it has great impact on psychological and social aspects of their lives, thus affecting their quality of life (QoL). Several studies assessing the quality of life in hirsute women could be found in world literature but none in Nepalese literature. So, this study was undertaken for the assessment of the impact of hirsutism on the quality of life in Nepalese women. Objective To assess the effect of hirsutism on quality of life of women in a tertiary center of Eastern Nepal and its association with various socio-demographic and clinical parameters. Method A cross-sectional questionnaire-based study was conducted in 49 participants aged 10 to 49 years at the Department of Dermatology, B.P. Koirala Institute of Health Sciences. Clinically diagnosed hirsute females with modified Ferriman-Gallwey (mF- G) score > 8, were enrolled and asked to fill Dermatology Life Quality Index (DLQI) questionnaire in the Nepalese version. Result More than 57.2% of the study population was of age 20 to 29 years with a mean of 27.76±8.08 years. The mean Dermatology Life Quality Index score was 7.78±4.95. The moderate effect was seen in the majority of participants (36.7%) with a predominant effect upon aspects of life like daily activities and symptoms and feelings. Participants with higher mF-G score (22.15±3.82) had a very large effect on their quality of life. Younger unmarried women with a school education and having a longer duration of hirsutism were found to have a higher effect upon their quality of life. However, the association was not statistically significant. Conclusion Hirsutism had affected the quality of life moderately with predominant effect upon aspects like daily activities and symptoms and feelings. No significant association was elicited between severity of hirsutism and its effect on quality of life from our study. KEY WORDS Hirsutism, Modified ferriman-gallwey score, Quality of lifePublication Leprosy after the Elimination: A BPKIHS experience(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2013) Bhattarai, S; Agrawal, S; Rijal, A; Marahatta, SNo Abstract: