Browsing by Author "Panta, Om Biju"
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Publication Correlation of Imaging Findings with Molecular Subtypes of Breast Cancer(Nepal Health Research Council, 2023) Panta, Om Biju; Dhakal, Vivek; Gurung, Bibek; Ghimire, Ram KumarAbstract Background: Ultrasound and Mammography are first-line imaging in breast cancer. The management of malignant breast lesions depends on molecular biomarkers in the tumor cells. This study aims to correlate different imaging findings in breast carcinoma with immune-histology subtypes. Methods: The study was a retrospective study conducted between 2018 January to 2021 December. Patients with malignant breast lesions who underwent USG-guided biopsy of breast lesions were included in the study. Ultrasound and mammographic findings of these patients were retrieved in PACS and analyzed. Malignant breast lesions were classified according to molecular markers into Luminal A, Luminal B, Her- 2 enriched, and triple-negative breast cancers. The correlation between imaging findings and molecular subtypes of breast cancer was analyzed. Results: A total of 42 patients were included in the study. The mean age of the patients in our study was 52.24+/-13.54 years with median of 51 years (IQ range-19.5 years). The most common IHC subtype was Luminal type B (22, 52.4%), followed by triple negative (15, 35.7%), luminal type A (4, 9.5%) and least common was Her-2 enriched (1, 2.4%). Mammogram was non-diagnostic in 9.5% of case. Oval shape and well marginated margin in ultrasound were more frequently associated with triple negative breast cancer than other subtypes (P<0.05). Rest of the characteristics of triple negative and other malignancies were not significantly difference in our study. No significant difference is noted between mammographic findings between various subtypes. Conclusions: Triple negative breast cancer was more common in our population than in the west. Triple-negative breast cancers are more frequently well-defined and oval in shape mimicking benign lesions. Keywords: Breast cancer; mammography; molecular subtypes; ultrasoundPublication Mean Intracranial Volume of Brain among Patients with Normal Magnetic Resonance Imaging Referred to the Department of Radiology and Imaging of a Tertiary Care Centre(Nepal Medical Association, 2023) Panta, Om Biju; Gurung, Bibek; Giri, Shahjan Raj; Adhikari,Abhishek; Ghimire, Ram KumarAbstract Introduction: The measurement of brain volume is an important aspect of the assessment of brain structure and function. However, limited data is available on brain volumetry in the Nepalese population. The study aimed to find the mean intracranial volume of the brain among patients with normal magnetic resonance imaging referred to the Department of Radiology and Imaging of a tertiary care centre. Methods: A descriptive cross-sectional study was conducted among patients with normal magnetic resonance imaging referred to the Department of Radiology and Imaging in a tertiary care centre. All magnetic resonance imaging of the brain during the study period was reviewed by a radiologist. Magnetic resonance imaging with abnormal findings, clinical signs of neurological deficit, dementia and psychiatric symptoms were excluded from the study. A convenience sampling method was used. The point estimate was calculated at a 95% Confidence Interval. Results: Among 285 Magnetic Resonance Imaging datasets, the mean intracranial volume was 1286.30±129.88 cc (1271.22-1301.38, 95% of Confidence Interval). The mean cerebral volume was 985.06±106.4 cc, cerebellar volume was 126.99±13.05 cc and brain stem volume was 19.97±2.54 cc. Conclusions: The mean intracranial volume of the brain among patients with normal magnetic resonance imaging was found to be lower than other studies done in similar settings.Publication Spondylolysis among Patients Without Low Back Pain in a Diagnostic Centre: A Descriptive Cross-sectional Study(Nepal Medical Association, 2023) Sharma, Bishwanath; Panta, Om Biju; Thapa, Bikash Raj; Thapa, SureshAbstract Introduction: Spondylolysis can either be asymptomatic or can cause significant low back pain. It is sometimes associated with the translation of one vertebra over another and is termed spondylolisthesis. The aim of the study was to find out the prevalence of spondylolysis among patients without low back pain in a diagnostic centre. Methods: A descriptive cross-sectional study was carried out in a referral diagnostic centre from 15 December 2018 to 14 December 2021 . Ethical approval was obtained from the Nepal Health Research Council (Reference number: 2903). Images of a computed tomography scan of the abdomen performed for other abdominal causes and without low back pain were reconstructed in the sagittal and coronal plane and evaluated for the presence of spondylolysis and spondylolisthesis in the lumbar spine. Demographic data were taken from the hospital records. Convenience sampling method was used. Point estimate and 95% Confidence Interval were calculated. Results: Among 768 patients without low back pain, spondylolysis was found in 59 (7.68%) (5.80-9.56, 95% Confidence Interval). Spondylolisthesis was found in only 16 (27.1%) individuals with spondylolysis. The majority of spondylolysis cases were encountered in L5 level in 54 (91.53%). The mean age of patients with spondylolysis was 41.9±14.46 years. Male to female ratio was 1:1.18. Conclusions: The prevalence of spondylolysis in our study was found to be similar to other studies done in similar settings.