Browsing by Author "Parajuli, Suraj"
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Publication Hashimoto’s Thyroiditis among Patients with Thyroid Disorders Visiting a Tertiary Care Centre(Nepal Medical Association, 2023) Parajuli, Suraj; Bhatt, Navin; Regmi, Anil; Chapagain, Subodh; Panday, Pradumna; Singh, Arjan; Nepal, Shristi; Karki, Pragya; Agrawal, Shweta; Bhattarai, JyotiAbstract Introduction: Hashimoto’s thyroiditis is a chronic autoimmune lymphocytic thyroiditis characterised by thyroid autoantibodies. Early detection and treatment of this condition help in reducing the morbidity and mortality associated with it. The aim of the study was to find out the prevalence of Hashimoto’s thyroiditis among patients with thyroid disorders visiting a tertiary care centre. Methods: A descriptive cross-sectional study was conducted among patients visiting the outpatient department of a tertiary care centre. Data from 14 April 2017 to 13 April 2019 was collected between 30 June 2022 to 15 September 2022 from medical records. Ethical approval was obtained from the Nepal Health Research Council. Hashimoto’s thyroiditis was diagnosed based on clinical presentation and positive antibodies to thyroid antigens. Convenience sampling method was used. The point estimate was calculated at a 95% Confidence Interval. Results: Among 813 patients with thyroid disorders, 393 (48.33%) (44.89-51.77, 95% Confidence Interval) had Hashimoto’s thyroiditis. The manifestation of the spectrum of Hashimoto’s thyroiditis were euthyroid in 215 (54.70%), subclinical hypothyroidism in 102 (25.95%), subclinical hyperthyroidism in 23 (5.85%), overt hyperthyroidism in 9 (2.30%) and overt hypothyroidism in 4 (1.02%). Conclusions: The prevalence of Hashimoto’s thyroiditis among patients with thyroid disorders was higher than in other studies done in similar settings.Publication Hyponatremia in Patients Admitted to Intensive Care Unit of a Tertiary Center: A Descriptive Cross-sectional Study(Nepal Medical Association, 2022) Parajuli, Suraj; Tiwari, Sanjeeb; Gupta, Sanjay Kumar; Shakya, Yogendra Man; Shakya, Yagya LaxmiAbstract Introduction: Hyponatremia is one of the common electrolyte abnormalities in intensive care unit settings. Hyponatremia may lead to an increased hospital stay, morbidity and mortality. Hyponatremia can occur due to a variety of iatrogenic as well as part of complex disease processes during hospital admission. The objective of this study was to find the prevalence of hyponatremia in patients admitted to the intensive care unit of a tertiary care centre. Methods: A descriptive cross-sectional study was conducted in the intensive care unit of a tertiary care centre for a duration of six months from 12 August 2015 to 11 January 2016. Ethical approval was taken from the Institutional Review Committee (Reference number: 124/6-11-E/072/073). Data was collected from hospital records. Patients with abnormal serum sodium levels after admission to the intensive care unit were included in the study. Hyponatremia was defined as a serum sodium level less than 135 mEq/L. Convenience sampling methods were used. Point estimate and 95% Confidence Interval were calculated. Results: Among 102 patients, the prevalence of hyponatremia was found to be 21 (20.59%) (12.74-28.44, 95% Confidence Interval). Conclusions: The prevalence of hyponatremia in patients admitted to the intensive care unit was higher than in other studies conducted in similar settings.