Browsing by Author "Paudel, Ashmita"
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Publication Prevalence of Colistin-resistant Gram-negative Isolates Carrying the mcr-1 Gene among Patients Visiting a Tertiary Care Center(Nepal Medical Association, 2020) Paudel, Ashmita; Devkota, Surya Prasad; Shrestha, Anima; Shah, Anil KumarAbstract: Introduction: Gram-negative isolates harboring mobilized colistin resistance (mcr-1) gene are a great threat to human health. They have been reported worldwide among various bacterial isolates. This work aimed to study the prevalence of colistin resistance among Gram-negative bacteria and the incidence of mcr-1 gene among these isolates. Methods: A descriptive cross-sectional study was done at a tertiary care center from June 2016 to February 2017. An ethical approval was taken from review board of the Nepal Health Research Council (Reg. no: 274/2016). Convenience sampling was used. The data was collected and analyzed using Microsoft Excel 2010 and Statistical Package for Social Sciences (SPSS) Version 16 . Point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data. Results: Among 485 gram-negative isolates, only 13 (2.68%) (1.26-6.62 at 95% Confidence Interval) isolates were colistin-resistant and mcr-1 was present in two isolates. Predominant colistin-resistant isolates were E. coli 6 (4.1%), Enterobacter spp 2 (2.81%), and Acinetobacter spp 2 (2.81%). A high level of colistin-resistance was noted in 4 (30.7%) isolates as indicated by the very high value of colistin MIC (>256 µg/ml). ICU was the major site of isolation of colistin-resistant and mcr-1 positive pathogens. The majority of colistin-resistant isolates were highly drug-resistant and were sensitive only to polymyxin B. Antibiotics like imipenem, amikacin, gentamicin, aztreonam, ciprofloxacin, and piperacillin-tazobactam were effective for few of these isolates. Conclusions: Though the prevalence of mcr-1 gene was low among colistin-resistant gram-negative isolates, the resistant pattern was quite alarming as these isolates were highly drug-resistant.Publication Retained bronchial foreign body diagnosed after 29 years of penetrating chest trauma(Nepalese Respiratory Society, 2022) Rimal, Ankit; Pun, Bishika; Karki, Bipin; Paudel, Ashmita; Pradhan, Utsav Lal; Shrestha, Pramesh SunderAbstract: This is a case of retained bronchial foreign body identified by Computed Tomography (CT) scan after 29 years of initial penetrating chest trauma. The patient had a long-standing history of shortness of breath which was diagnosed and treated as recurrent pulmonary infections. The case report is an attempt towards eliciting the importance of CT scan in identifying such foreign bodies. Interpretation & diagnosis of long standing organic foreign bodies may present with occasional diagnostic dilemma. However, prompt and accurate diagnosis is necessary to prevent complications that can be serious and, as in our case, potentially fatal.