Browsing by Author "Paudel, U"
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Publication Apocrine Carcinoma Developing in a Naevus Sebaceous of Scalp(Kathmandu University, 2012) Paudel, U; Jha, A; Pokhrel, DB; Gurung, D; Parajuli, S; Pant, AABSTRACT Apocrine skin carcinoma is an aggressive cutaneous tumour. We report a case of apocrine carcinoma developing in a naevus sebaceous of scalp in a 45 years old male. Malignant transformation of Naevus sebaceous is a rare complication usually found in elderly patients. Most of these tumours are basal cell carcinoma or squamous cell carcinoma. Only few cases of apocrine carcinoma on naevus sebaceous have been previously reported. This report highlights the potential of naevus sebaceous for malignant transformation. KEY WORDS Apocrine, Basal cell carcinoma, carcinoma, hamartoma, nevus, Sebaceous of Jadassohn, skin.Publication Clinical and Pathological Features of Primary Cutaneous Lymphomas in Nepal: A retrospective cohort study from a dermatology referral centre(Kathmandu University, 2024) Paudel, U; Parajuli, SABSTRACT Background Primary cutaneous lymphomas (PCLs) are rare diagnoses in Nepal and are not well characterized till date. Objective To evaluate clinical and pathological features of Primary cutaneous lymphomas in Nepal. Method We retrospectively reviewed outpatient and inpatient records of a dermatology referral centre of Kathmandu, Nepal for clinical and pathological findings of cases diagnosed as cutaneous lymphomas from July 2010 through July 2020. The final diagnosis was made based on 2008 World Health Organization classification and its update 2018. Result There were 12 cases of Primary cutaneous lymphomas diagnosed during this period. The age of presentation ranged from 19 years to 81 years (Mean: 53.4 years ± 21.5 years, SD). There were ten cases of cutaneous T-cell lymphoma (CTCLs) and two cases of cutaneous B- cell lymphomas (CBCLs). Among cutaneous T-cell lymphoma, there were four cases of primary cutaneous anaplastic large- cell Lymphoma (PCALCL), two cases of classic (patch/plaque) mycosis fungoides (MF), two cases of folliculotropic mycosis fungoides (FMF), and one case each of primary cutaneous aggressive epidermotropicCD8+ T-cell lymphoma and lymphomatoid papulosis. Among cutaneous B- cell lymphomas, there was one case of primary cutaneous marginal zone B- cell lymphoma, and one case of primary cutaneous follicle centre lymphoma. Most cases of MF presented at stage IB (75%), and three patients of primary cutaneous lymphomas died during this period. Conclusion Primary cutaneous lymphomas appear to be very rare in this study and presentations ranged from classic Mycoses Fungoides to aggressive T-cell lymphomas. Cutaneous T-cell lymphomas appeared to be more common than cutaneous B- cell lymphomas in this study. KEY WORDS Anaplastic, B-cell, Cutaneous, Lymphoma, T-CellPublication Clinico-bacteriological profile and antibiotic sensitivity pattern in pyodermas: A Hospital Based Study(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2013) Paudel, U; Parajuli, S; Pokhrel, DBNo Abstract Keywords: Antibiotic sensitivity pattern, bacteriological profile, PyodermasPublication Cutaneous Leishmaniasis in Natives of Central Region of Nepal(Kathmandu University, 2019) Paudel, U; Parajuli, S; Poudel, AS; Paudel, V; Pokhrel, DBABSTRACT We report two cases of cutaneous leishmaniasis in natives of central region of Nepal. The first patient in our series, an adult female, presented with a small nodule on the philtrum of upper lip and the second case, a male child, presented with two crusted plaques on forehead. The final diagnosis was based on histopathological findings; however, species characterization was not possible because of its unavailability in the country. These patients responded well to the treatment with Miltefosine (First case) and Fluconazole (second case). Moreover, these cases sparks a question about the origin of diseases in this region and calls for further research in future to find out the cause and prevalence of this disease in Nepal. This case report also emphasizes to consider cutaneous leishmaniasis as differential diagnosis for granulomatous presentations in our context. KEY WORDS Cutaneous leishmaniasis, Fluconazole, MiltefosinePublication Dexamethasone Cyclophosphamide Pulse Therapy in Dermatology(Institute of Medicine, 2008) Parajuli, S; Paudel, U; Pokharel, DBAbstract Introduction: The objectives of this study was to: study profile of dermatological disease treated with pulse therapy in TUTH , determine the clinical time to remission of diseases, duration of remission after withdrawal of treatment and determine the side effect profile of the treatment. Materials and Methods: Demographic profile of the patients treated with pulse therapy for various dermatological conditions, the duration of diseases prior to treatment, the clinical time to remission of diseases, duration of remission after withdrawal of treatment and side effects of treatment. Results: Pulse therapy was received by 12 patients, five patients were SLE (F: M-4:1) with mean age of onset 28.75yrs, six patients were of Pemphigus (F: M-1:1) with mean age of onset 30.6 yrs and there was one 40 yrs old female patient of scleromyxoedema. The mean duration of disease prior to treatment was 2.8 yrs in SLE and 1.4 yrs in Pemphigus. The mean duration of clinical time to remission was 4 months for SLE while only one patient of Pemphigus had received clinical remission after 6 months. Duration of remission after withdrawal of treatment could not be ascertained because none of them had completed phase III. The main side effects observed in our study were flushing and secondary infection. Conclusion: DC pulse therapy appears to be encouraging treatment in the treatment of dermatological conditions like SLE, Pemphigus and scleromyxoedema. However study involving a large number of patient and long duration of follow up is needed before considering it as best treatment available for treatment of these conditions. Keywords: Dexamethasone cyclophsophamide pulse, Pemphigus, SLE, ScleromyxoedemaPublication In patient dermatology: characteristics of patients and admissions in Tribhuvan University (TU) Teaching Hospital(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2013) Parajuli, S; Paudel, U; Pokhrel, DBNo Abstract Keywords: Inpatient dermatology, patterns, NepalPublication Klippel -Trenaunay Syndrome: A Case Report(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2012) Paudel, U; Gupta, Sonia; Pant, A; Bagaria, R S; Shrestha, D PNA Keywords: Klippel -Trenaunay Syndrome, capillary- venous malformationPublication Managing Deep Mycoses in Nepal is still a challenge: case report of actinomycetoma, a neglected tropical disease(Institute of Medicine, 2018) Paudel, U; Sharma, R; Parajuli, SAbstract Deep mycoses are frequent diagnoses in Nepal. Most of the cases remain undiagnosed because of unavailability of specific diagnostic services in our setting. We report a case of deep mycosis, in a 60-year-old male, who presented with multiple nodules and scars on his neck and chest, and was histopathologically diagnosed as actinomycosis.The culture was negative. The patient did not respond to treatment with penicillin initially, however, on starting co-Trimoxazole , the lesions resolved in two months, thus pointing towards diagnosis of actinomycetoma. The patient remained disease free at last follow- up at two years. The case highlights importance of considering actinomycetoma as one of the differential diagnosis of such presentation and also need of developing well set reference laboratory in order to reach to a proper diagnosis. Key words: Actinomycetoma, cotrimoxazole, deep mycoses, Neglected diseases