Browsing by Author "Pradhan, Santosh"
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Publication Serum Vitamin B12 Level in Children with Type 1 Diabetes(Nepal Health Research Council, 2025) Pradhan, Santosh; Thapa, Subhana; Shrestha, Pradeep Krishna; Jha, BharatAbstract Background: Type 1 Diabetes Mellitus is known to be associated with multiple co-morbidities. Vitamin B12 deficiency is a potential co- morbidity that might have been overlooked in these patients. The aim of this study is to evaluate the serum level of vitamin B 12 in a well-defined population of Type 1 diabetes. Methods: The cross sectional study carried out on 40 patients with Type 1 Diabetes Mellitus visiting endocrinology unit in Kanti children’s Hospital, Kathmandu, Nepal. Thirty healthy non diabetics were also selected. Serum C-peptide, vitamin B12, creatinine, blood glucose level and glycosylated hemoglobin were assessed in both groups. SPSS ver. 22 was used to analyze the data. Results:The mean serum vitamin B12 level of the diabetic group was 206.92±82.18 pmol/L. Among the population 40.0% i.e. 16 out of 40 were found to be deficient and 37.5 % i.e. 15 out of 40 were subclinically deficient. Whereas the mean serum vitamin B12 level of the non diabetic group was 340.71±136.02pmol/L. Out of 30 only 2(6.7%) were deficient, 8 (26.75%) were found to be subclinically deficient. Significant difference was noticed in the mean serum level of vitaminB12 between these two groups. Conclusions: This study shows the presence of low serum vitamin B12 levels in Type 1 Diabetics. The routine screening for this condition along with confirmatory test and detail clinical examination could benefit the patients with Type 1 diabetes. Keywords: Autoimmune disease; Type 1 Diabetes mellitus; Vitamin B12.Publication Variation in Laboratory Reports: Causes other than Laboratory Error(Nepal Medical Association, 2022) Pradhan, Santosh; Gautam, Keyoor; Pant, VivekAbstract: When a sample of an individual is measured at different times at the same or different clinical laboratory, the results are always different, even the state of health of an individual is the same. This disparity in the results from clinical laboratories might confuse diagnosing, treating, and monitoring disease. Patients and healthcare professionals usually interpret these differences as laboratory errors. However, this might not always be the case, because laboratory test results are highly variable and are neither consistent nor comparable due to several reasons other than laboratory error, namely preanalytical variation, biological variation, and analytical variation.