NepMed Repository :: Browsing by Author "Pradhanang, S"

Browsing by Author "Pradhanang, S"

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A Histopathological Study of Gastrointestinal Polyps in Tertiary Care Hospital, Nepal
(Institute of Medicine, 2014) Gurung, P; Hirachand, S; Pradhanang, S; Lama, S
Abstract Introduction: Gastrointestinal polyps may be non-neoplastic or neoplastic lesions. They are mostly asymptomatic and are common in the colon but may occur anywhere in the gastrointestinal tract. Some polyps have an increased risk for malignancy, so it is important to determine the histologic type and characteristics for treatment. This study was undertaken to determine the histomorphological spectrum of polyps, their potential risk for malignancy, and frequency in our center. Methods: This is a descriptive study which was carried out at Kathmandu Medical College Teaching Hospital for a period of three years from 1st January 2011 to 31st December 2013. A total of 67 polypectomy specimens were received and processed in the Pathology Department. Hematoxylin and Eosin stained slides were examined. Results: 47 (70.1%) gastrointestinal polyps were non-neoplastic, 19 (28.3%) were neoplastic and 1 (1.6%) was an infarcted polyp. Most of the patients presented with rectal bleeding. The age of patients for non-neoplastic and neoplastic polyps ranged from 3-74 and 23-78 years, respectively. Amongst the non-neoplastic polyps, 21 (44.7%) were retention polyps, 14 (29.8%) were inflammatory polyps, 10 (21.3%) were hyperplastic polyps, 1 (2.1%) benign gastric polyp and 1 (2.1%) non-categorized polyp. The neoplastic polyps had 16 (84.1%) adenomatous polyps, 1 (5.3%) mixed polyp, 1 (5.3%) fundic gland polyp, and 1 (5.3%) moderately differentiated adenocarcinoma. 11 (68.8%) adenomatous polyps had mild dysplasia, 2 (12.5%) moderate dysplasia, and 3 (18.7%) severe dysplasia. Size of the non-neoplastic polyps ranged from 0.2-5.0 cm and size of neoplastic polyps ranged from 0.3-6.0 cm in diameter. Some patients presented with more than one polyp. Conclusion: Polyps have a diverse histomorphology and there is a risk of malignancy in the adenomatous polyps so it is important to screen patients for treatment and cancer prevention. Keywords: adenomatous polyps, hyperplastic polyps, inflammatory polyps, retention polyps
A study on fine needle aspiration cytology of epididymal nodules
(Institute of Medicine, 2018) Thapa, R; Gurung, P; Kafle, N; Pradhanang, S; Hirchand, S; Lakhey, M; Joshi, R
Abstract Introduction: Fine needle aspiration cytology (FNAC) is a rapid and relatively inexpensive technique used extensively in the diagnosis of a large variety of neoplastic and nonneoplastic lesions in many organs.There are very few literature reports documenting the role of fine needle aspiration cytology (FNAC) in the evaluation of epididymal nodules. The aim of this study was to highlight the cytomorphologic features of FNAC in epididymal nodules. Methods: A descriptive study was carried out in all the patients presented with palpable epididymal nodules for FNAC over a period of two and half years in department of pathology, Kathmandu Medical College Teaching Hospital, Sinamangal, Kathmandu. FNAC was performed using 23 gauge needle with 10ml syringe. Smears were routinely stained with PAP, Giemsa stain and Special stains whenever needed. Results: A total of 31 cases of non – neoplastic lesions were identified. Age ranged from 15 to 52 years. Majority of cases were of tuberculous epididymitis accounting for 38.70%. Conclusions: FNAC serves as an important tool to screen and diagnose all palpable epididymal nodules and provides information for further management. Keywords: Fine needle aspiration cytology, epididymal nodules, neoplastic, non-neoplastic lesions
Histopathological study of ovarian cystic lesions in Tertiary Care Hospital of Kathmandu, Nepal
(Institute of Medicine, 2013) Gurung, P; Hirachand, S; Pradhanang, S
Abstract Introduction: Ovarian cysts are commonly encountered lesions. They are amongst the most frequent cause of hospitalization and surgery in gynecological practice. One cannot confidently distinguish a benign lesion from a malignant one on the basis of clinical, radiological or gross characteristics along so a histopathology examination is a must as it guides therapy. The study was undertaken to determine the morphologic spectrum of the cystic lesions of the ovary. Methods: This is a descriptive study which was carried out at Kathmandu Medical College Teaching Hospital for a period of two years from 1st January 2011 to 31st December 2012. A Total of 135 cases of ovarian cysts were received and processed in the Pathology Department. Hematoxylin and Eosin stained slides were examined. Results: Among the 135 ovarian cystic lesions, 119 cases (88.15%) were unilateral and 16 cases (11.85%) were bilateral. There were 59 cases (43.7%) of benign cysts, 69 cases (51.1%) of benign tumors, 5 cases (3.7%) of malignant tumors and 2 cases (1.5%) of borderline epithelial tumors. The age of patients ranged from 13 years to 73 years with mean age of presentation of 43 years. Among the ovarian cystic lesions the incidence of mature cystic teratoma was the highest (30%). The most common non-neoplastic cyst was endometriotic cyst (39%), while the most common benign tumor was mature cystic teratoma (58%). The malignant tumor encountered in the study was serous cystadenocarcinoma. Two cases of borderline epithelial tumors (1.5%) were also observed in the study. Conclusion: The most common cystic lesion that were encountered in the study was benign tumor followed by benign cyst. Of the benign tumors, mature cystic teratoma was the most frequently observed lesion. Among the non-neoplastic cysts, endometriotic cyst was the most frequently observed lesion. Keywords: borderline tumors, endometriosis cyst, mature cystic teratoma, Ovarian cyst, serous cystadenocarcinoma
Utility of Rapid Brilliant Cresyl Blue Stain in Routine Fine Needle Aspiration Cytology
(Institute of Medicine, 2017) Gurung, P; Hirachand, S; Thapa, R; Pradhanang, S; Kafle, N; Acharya, S; Sedhain, M
Abstract Introduction: Rapid on-site evaluation is commonly performed by pathologists to check for cellular adequacy of fine needle aspirate smears to reduce hospital visits of patients and to make preliminary diagnosis. For rapid evaluation, laboratories use Romanowsky stain, Hematoxylin and Eosin stain, supravital stains and ultra-fast Papanicolaou stain. The aim of the study is to evaluate fine needle aspirate smears on-site for sample adequacy using supravital stain Brilliant Cresyl Blue (BCB), to make preliminary cytological diagnosis and to compare with the routine cytological Papanicolaou stain (Pap) and Giemsa stain. Methods: The study was carried out in the Department of Pathology, Kathmandu Medical College Teaching Hospital from 1st December, 2014 to 31st December, 2015. A total of 115 cases referred from OPD for FNAC were included in the study. FNA was performed under aseptic conditions with a 23-guage needle. Samples were collected for routine stains (Papanicolaou and Giemsa stain) and one air-dried slide was stained with Brilliant Cresyl Blue and examined immediately while patient was in waiting room. Results: Of the 115 cases, the age of patients ranged from 15 to 83 years in which male and female ratio was 1.5:1. There were 35 (30.4%) cases of enlarged lymph nodes, 28 (24%) cases of thyroid lesions, 20 (17.3%) cases of breast lesions, 7 (6%) cases of soft tissue lesion, 3 (3%) cases of salivary gland lesions, 1 (1%) case of lung mass, 1 (1%) case of epididymal swelling and others 20 (17.3%) cases. On rapid staining with brilliant cresyl blue, case sample adequacy was 104 (90%). Repeat aspiration was done in 11 (10%) of cases .Upon rapid staining, 92 (80%) of the cases were benign, 19 (17%) cases were malignant, 4 (3%) cases were inconclusive. After observation of papanicolaou and giemsa stains, there were 94 (82%) benign cases and 21 (18%) malignant cases. Conclusion: On-spot Brilliant Cresyl Blue staining is a good stain to check for sample adequacy and to reduce reaspirations. It is as good as the conventional stains in exhibiting cytomorphology of cells. Keywords: Brilliant Cresyl Blue, cytomorphology, fine needle aspiration cytology, Giemsa stain, Papanicolaou stain

Browsing by Author "Pradhanang, S"

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