Browsing by Author "Roy, S"
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Publication Association of Serum Vitamin D Level with its Receptor Gene Polymorphism Bsml in Beta Thalassemia Major Patients from East India(Kathmandu University, 2018) Sinharay, M; Roy, S; Dasgupta, AABSTRACT Background Vitamin D deficiency is commonly identified in beta thalassemia major patients, related to iron accumulation.Vitamin D mediates its action upon binding to vitamin D receptor (VDR), a classical nuclear receptor. Several single nucleotide gene polymorphisms has been identified in VDR gene among which Bsml is commonly studied for its association with bone mineralisation and osteoporosis. Objective To explore the association between the Vitamin D Receptor Polymorphism (BsmI) and serum levels of Vitamin D, ionised Calcium, alkaline phosphatase in patients with beta thalassemia major. Method VDR gene was studied for Bsml polymorphisms from purified DNA in thirty six beta thalassemic patients (cases) - fourteen male and twenty two females, and thirty three controls after amplification by PCR followed by restriction digestion using appropriate restriction enzymes. Allelic differences between two groups were assessed by chi square and odds ratio test. Any potential link between the polymorphic variations and vitamin D status were assessed by post hoc ANOVA with bonferroni correction among the three genotypes. Result The distribution of BB genotype was significantly higher among the case groups (thalassemic group, χ2= 9.77, p= 0.008). The odds ratio for the allele B was significantly higher in thalassemia group for a range of 1.97 to 5.94 for 95 percent cofidence interval (χ2=10.4, p=0.0013). Serum Vitamin D, ionised Calcium were significantly low (p < 0.001) and Alkaline phosphatase (p < 0.001), was significantly high in thalassemics (cases). The genotype BB group had significantly low Vitamin D (p=0.001) and ionised Calcium (p < .001) compared to Bb and bb. The bb genotype had the highest levels of Vitamin D and ionised Calcium among the three genotypes. Conclusion The thalassemic patients are prone to Vitamin D deficiency and the superimposed predominance of BB genotype in them may be a risk factor for osteoporosis and cardiac dysfunction. Moreover, the study indicated genotype bb to have a probable protective role against Vitamin D deficiency in beta thalassemic patients KEY WORDS Beta thalassemia, Vitamin D receptor , Vitamin D receptor genePublication Multiple arterial anomalies in upper limb(Kathmandu University, 2009) Baral, P; Vijayabhaskar, P; Roy, S; Kumar, S; Ghimire, S; Shrestha, UAbstract An isolated neurovascular variation is common but multiple vascular anomalies on same upper limb is a very rare case. We observed an unusual variations in right upper limb during routine dissection of a Nepali cadaver . The variations were observed in Axilla, Forearm and Palm. In axilla, first part of axillary artery did not give any branch, the second part of axillary artery gave off only two branches - (a) thoracoacromial artery and (b) a large common trunk which later gave off lateral thoracic, thoracodorsal, subscapular, posterior circumflex scapular and then continued as posterior circumflex humeral artery. The third part of axillary artery gave off only anterior circumflex humeral artery. In forearm, the ulnar artery runs downward superficial to flexor muscles. Here, radial artery gave off common interosseous artery. In palm radial artery did not give any contribution to superficial palmar arch which is solely formed by the continuation of ulnar artery. This type of anomalies are very rare and is not reported in Nepalese cadaver at all. These anomalies are described in detail and their clinical relevance is highlighted. Key words : Axillary artery, Brachial artery, Radial artery, Ulnar artery, Palmar arch, VariationsPublication What’s Shaping Medical Student’s Attitude Towards Lesbian, Gay, Bisexual, And Transgender (LGBT) Community?(Kathmandu University, 2024) Roy, S; Bandyopadhyay, L; Chakraborty, A; Sahu; Paul, B; Kumar, RABSTRACT Background Lesbian, Gay, Bisexual, and Transgender (LGBT) people form the basis of sexual and gender minority groups who face discrimination in their daily lives, including in healthcare facilities even though they are quite vulnerable to certain health problems. Medical student’s attitudes towards the Lesbian, Gay, Bisexual, And Transgender community greatly shape the healthcare service delivery as well as service utilization by them, thus influencing their health status in the long run. Objective To find out the knowledge, attitude, judgment, and experience of a medical student regarding the Lesbian, Gay, Bisexual, And Transgender community and its associated factors. Method This institution-based Cross-Sectional study approved by the Institutional Ethics Committee was conducted among 216 medical undergraduates of a medical college from October 2022 to February 2023 after a pilot study. Sampling was done by Stratified Random Sampling. Data were collected anonymously by using an online questionnaire. Data were analyzed via Statistical Package for Social Sciences (SPSS) software using univariate and multivariable logistic regression. Result Only 37.5% of medical students had sufficient knowledge regarding the Lesbian, Gay, Bisexual, And Transgender community (mean knowledge score 69.26 ± 14.6). Upper socio-economic class students had a more positive judgment (p-value: 0.012) and positive experience (p-value: 0.040). The presence of personal contact made a significant difference in attitude (p-value: 0.001), judgment (p-value: 0.012), and experience (p-value < 0.001). Conclusion The overall attitude of medical students regarding the Lesbian, Gay, Bisexual, And Transgender community was inadequate. Their knowledge and attitude were most positively affected by any personal contact with the Lesbian, Gay, Bisexual, And Transgender community thus peer-to-peer counseling among medical students might be helpful to shed conservative attitudes and be more open-minded. KEY WORDS Attitude, Judgment, Knowledge, LGBT, Medical students, Perception