Browsing by Author "Schreiber, Jens"
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Publication Allergic sensitization and obstructive airway diseases among an adult rural population in Nepal(Nepalese Respiratory Society, 2022) Drews, Arne; Lama, Poonam; Nepal, Niraj; Joshi, Rajesh Dhoj; Gran, Anja; Schreiber, JensAbstract: Background: The relevance of the obstructive lung diseases asthma and COPD and IgE-mediated allergy in Nepal is still poorly characterized. Method: In a cross-sectional study in rural Nepal 199 persons were characterized with a questionnaire, skin prick tests, spirometry and total IgE concentration in serum. Results: About 20% of the women and 50% of the men were current smokers. Half of the study population used biomass fuel at home to cook or to heat and 70% of the study participants experienced dust-exposure at work or at home. 50% of the women and 30% of the men had a history of COPD, while 57% of the women and 53% of the men had symptoms of respiratory allergy. 18% of the women and 16% of the men used inhaler devices. 62% of the women and 66% of the men had a total IgE concentration in serum >100 IU/mL. About 30% of the women had a FEV1 < 80% and about 10 % had a FEV1 < 40%, also 30% of the men had a FEV1 <80% but none of the men had a FEV1 <40%. The FEV1/VC ratio was smaller than 70% in 13 % of the women and 14,6% of the men. We observed a significant inverse correlation between serum IgE with FEV1. 14% of study participants had positive prick test for house dust mite, 5% were positive for cat dander and 3% were positive for mugwort. Conclusion: In summary this study shows an relevant burden of obstructive pulmonary disorders and IgE-mediated allergy in a rural Nepalese population.Publication Asthma – Inhaled Corticosteroids (ICS): different molecules - different devices – different treatment concepts: what really makes a difference?(Nepalese Respiratory Society, 2024) Singla, Abhinav; Stegemann-Koniszewski, Sabine; Lücke, Eva; Kahlfuss, Sascha; Schreiber, JensAbstract Bronchial asthma is a chronic, heterogeneous disease with different clinical phenotypes and inflammatory endotypes. Anti-inflammatory treatment with inhaled corticosteroids (ICS) has revolutionized the therapy of asthma and is indicated in almost all patients across all degrees of severity and therapy stages. Nevertheless, there is a broad spectrum of ICS molecules, dosages, combination partners, application concepts (maintenance therapy and/or as-needed therapy), and devices. Thus, there is a large number of variables, whose clinical significance is often unclear. This overview will therefore present clinically relevant aspects in the use of ICS and their combination partners.