Browsing by Author "Shah, AK"
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Publication En Bloc Versus Conventional Resection of Primary Bladder Tumor(Kathmandu University, 2025) Thapa, BB; Shah, AK; Adhikari, B; Mishra, U; Dahal, R; Rasali, N; Basnet, RB; Shrestha, PM; Shrestha, AABSTRACT Background Transurethral resection of bladder tumor (TURBT) is the crucial and standard approach in the diagnosis and management of urinary bladder cancer. Objective To compares conventional piecemeal and en bloc resection techniques in terms of detrusor muscle presence in resected specimens, surgical safety, and feasibility. Method A prospective comparative study conducted from April 2024 to March 2025 included patients with up to three bladder tumors, measuring ≤ 3 cm, who were alternately assigned to undergo either conventional piecemeal resection or en bloc resection. The primary outcome was the presence of detrusor muscle in the resected specimen. Secondary outcomes included operative time duration, bladder perforation, and obturator reflex. The quality of tissue was assessed by pathologists using a Likert scale. Result Eighty-seven patients were included, 43 in the conventional and 44 in the en bloc group. The baseline characteristics and tumor size were comparable. Presence of detrusor muscle in specimens was higher in en bloc group (97.7% vs 83.7%; p = 0.030). Operative duration was shorter in the en bloc group (35.55 minutes vs 43.42 minutes; p = 0.001). A case of bladder perforation was observed in the conventional group. Pathologists observed better specimen orientation and architecture in the en bloc group. Presence of tumor in re-TURBT was 16.0% in the en bloc group and 28.6% in the conventional group (p=0.497). Conclusion En bloc resection yielded a higher presence of detrusor muscle and shorter operative duration with better specimen quality compared to conventional piecemeal resection for tumor ≤ 3 cm. KEY WORDS Detrusor muscle, En bloc resection, Transurethral resection of bladder tumorPublication Feasibility, Safety and Acceptance of Buccal Mucosa Harvest Under Local Anesthesia for Substitution Urethroplasty: Prospective Observational Study in a Tertiary Centre(Kathmandu University, 2024) Pandey, A; Shrestha, PM; Shrestha, A; Basnet, RB; Adhikari, B; Shah, AK; Mishra, UABSTRACT Background Urethral stricture is a challenging condition with significant socioeconomic impacts, often requiring surgical intervention such as urethroplasty. Buccal mucosa grafts (BMG) are a popular choice for substitution urethroplasty due to their favorable outcomes. This study evaluates the feasibility, safety, and acceptance of harvesting buccal mucosa grafts under local anesthesia. Objective To assess feasibility, safety and acceptance of Buccal mucosa harvest under local anesthesia. Method A prospective observational hospital based study to evaluate outcomes of substitution urethroplasty using buccal mucosa grafts (BMG) under local anesthesia. Result Of the 40 patients, 28 had unilateral graft harvests, while 12 had bilateral procedures. The mean graft length obtained was 5.65 cm. Postoperatively, patients experienced a quick recovery, with full mouth opening achieved within an average of 2.78 days and resumption of normal eating within 2.6 days. Minor complications included oral swelling in 15% of cases and food residue in 12.5%. Although 87.5% of patients reported pain at the perineal wound site, the overall pain score averaged 3.58, indicating manageable discomfort. Importantly, 92.5% of patients expressed a willingness to undergo the procedure again if necessary. Conclusion These findings suggest that buccal mucosa graft harvest under local anesthesia is both feasible and well-tolerated. The procedure appears to be a safe alternative to regional or general anesthesia, with minimal complications and a high level of patient acceptance. Future randomized controlled trials comparing local anesthesia to regional or general anesthesia could provide additional insights and further validate these findings. This study contributes to the growing body of evidence supporting the use of local anesthesia in urethral stricture surgery, offering a practical approach to managing this condition effectively. KEY WORDS Buccal mucosa graft, Feasibility study, Local anesthesia, Substitution urethroplasty, Urethral stricturePublication Outcome of Transurethral Vaporisation of Prostate in Small Volume Prostate: A prospective observational study(Kathmandu University, 2024) Dahal, R; Adhikari, B; Mishra, U; Shah, AK; Basnet, RB; Shrestha, A; Shrestha, PMABSTRACT Background Benign Enlargement of Prostate is common in aging men. Transurethral vaporisation of prostate is one modality of minimal invasive management of benign enlargement of prostate. This study assesses the efficacy and safety of transurethral vaporisation of prostate in small volume prostate. Objective To assess the efficacy and safety of bipolar plasma vaporisation of small volume prostate (Prostate Volume less than 40 grams). Method A total of 40 patients with prostate volume less than 40 grams and indications for operative management of benign enlargement of prostate were included. Patients with prior prostate surgery, urethral stricture surgery, presence of vesical calculus, urethral stricture and neurogenic bladder were excluded. Preoperative prostate size was assessed by transrectal ultrasonography. Comparison of preoperative and postoperative hemoglobin, sodium, international prostate symptom score and maximum flow rate was done. Perioperative complications were documented. Result The mean age of patients was 66.88 ± 9.09 years and the mean size of prostate was 32.52 ± 4.66 grams. Significant improvement in IPSS (preoperative 22, postoperative 9) and Qmax (preoperative 8.4 ml/min, postoperative 18.5 ml/min) was noted. There was significant drop in hemoglobin (p < 0.001) but no patients required blood transfusion. There was significant drop in sodium (p < 0.001) but no patients developed transurethral resection syndrome. Most complications were Clavien grade I. Two patients required recatheterization and all were catheter free on follow up. Two patients developed urethral stricture. Conclusion Bipolar transurethral vaporisation of Prostate is effective and safe treatment option for prostate volume less than 40 grams. KEY WORDS Bipolar plasma vaporisation, Lower urinary tract symptoms, Prostate symptoms