Browsing by Author "Shakya, Nabin Bhakta"
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Publication A Hospital Based Study of Association of Chronic Spontaneous Urticaria with Autologous Serum Skin Test(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2020) Giri, Uma; Kayastha, Bhaskar MM; Shakya, Nabin BhaktaAbstract: Introduction: Chronic Spontaneous Urticaria (CSU), is spontaneous occurrence of wheals for more than 6 weeks. CSU patients with autoreactivity as indicated by positive Autologous serum skin test (ASST) have severe disease requiring higher doses of antihistamines and even immunomodulatory agents. Objective: The objective of this study was to observe the association between CSU and ASST. Materials and Methods: Over a period of one year, 104 CSU patients were enrolled in the study. Autologous serum skin test was done using 0.05 ml of patient’s serum, with 0.05 ml of histamine as positive control and normal saline as negative control. Prevalence of positive ASST in CSU patients was determined. Clinical and demographic characteristics were compared in both ASST positive and negative patients. Results: The ASST was positive in 68 patients (65.4%). Mean age (SD) of the patients in ASST positive group was 33.78 (14.38) versus 35.64 (14.47) in ASST negative group (p=0.533). Male:Female ratio in ASST group was 1:2.7 versus 1:1.1 in ASST negative group (p=0.033). Patients with positive ASST had significantly longer duration of wheals (p=0.002), generalized distribution (p=0.020) and high rmean urticaria activity score, 4.66 versus 3.28 in ASST negative patients, p<0.001. Angioedema was more common in ASST positive patients (p < 0.001). Conclusion: ASST was significantly positive in CSU patients and more common in females. ASST positive patients had more severe clinical manifestations and it can be a simple test to detect severe form of CSU. Keywords: Angioedema, Chronic Urticaria, Histamine, Skin TestsPublication Cutaneous Manifestations In the Patients With Covid 19: A Prospective Clinical Analysis(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2022) Jha, Sagar Mani; Shakya, Nabin Bhakta; Dangol, Anil Kumar Singh; Shakya, Sunil; Yadav, Jyotshna; Maharjan, Manisha; Panday, ShrikantAbstract: Introduction: The COVID-19 pandemic has become a major health care issue worldwide. The surge in cases was seen in the second wave, with more people getting hospital admissions. An accurate and rapid identification of cutaneous manifestations is vital to early diagnosis and better prognosis. The aim of the study was to determine cutaneous manifestations in patients with COVID-19. Materials and Methods: This prospective observational cross-sectional hospital-based study was conducted from June 2021 to September 2021. Patients admitted to the hospital were examined by the dermatologists. All inpatients diagnosed with COVID-19 with RT PCR were included. Types, patterns and how the skin lesions changed its course during illness were recorded. Ethical clearance was taken from IRC. Statistical analysis was done with SPSS Version 20.0. Results: A total of 452 COVID-19 RT-PCR-positive patients were enrolled out of which 97(21.5%) had skin lesions. Out of 131 comorbid patients, 40(30.5%) had skin lesions. Urticarial wheals and erythema nodosum were seen in 21(4.6%) each and were the most common manifestation, followed by exanthema in 17(3.8%). Conclusion: Study showed maximum patients with COVID-19 had urticaria and erythema nodosum. It is important to know the types of skin lesions for early diagnosis. In order to prevent the spread patient can be sent for investigations on time. More elaborate studies with multicenter involvement are recommended.