Browsing by Author "Sharma, Mohan Raj"
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Publication Clinical Characteristics and Outcome of Patients with Distal Anterior Cerebral Artery Aneurysms(Nepal Health Research Council, 2024) Bohara, Sandeep; Pradhanang, Amit Bahadur; Sedain, Gopal; Sharma, Mohan RajBackground: Distal anterior cerebral artery aneurysms account for 3% to 7% of intracranial aneurysms. They have increased risk of premature rupture during surgery and tend to have a higher morbidity. We aim to determine the clinical characteristics, management strategies and outcomes of patients with these aneurysms who underwent microsurgical clipping at a major university hospital in Nepal. Methods: This is a retrospective study of patients with distal anterior cerebral artery aneurysms who underwent microsurgical clipping between 2012-2022. Demographic data and clinical-radiological factors like Hunt and Hess grade, aneurysm location, and modified Rankin scale score at three, six, and 12 months were collected. Results: A total of 26 aneurysms were microsurgically clipped in 20 patients in ten years. Most patients presented with Hunt and Hess grade II. Of the 26 aneurysms, 16 (62%) were in A3 segment. Six patients had associated anterior communicating artery aneurysm, two patients had middle cerebral artery aneurysm and two patients had associated arteriovenous malformation. Sixteen patients (80%) had a favorable outcome (modified Rankin scale ?2) at 12 months follow-up. Conclusions: Aneurysms in the distal anterior cerebral artery locations are a challenging subset of aneurysms to treat. The majority of the patients had aneurysms in A3 segment and 80% patients had a favourable outcome at 12 months follow up period. Keywords: Aneurysm; distal anterior cerebral artery; outcome; subarachnoid haemorrhage.Publication Nature of Research Proposals Submitted to Institute of Medicine Institutional Review Committee: A Retrospective Review(Nepal Health Research Council, 2025) Tiwari, Ashish; Sharma, Mohan Raj; Shrestha, Lava; Bali, Kanchana; Bhatta, Om PrakashAbstract Background : Efficient evaluation of research proposals is crucial for ensuring ethical standards and scientific rigor in healthcare. This study aims to analyze the proposals submitted to the Institutional Review Committee (IRC) of the Institute of Medicine (IOM) to determine the trends in health-related research conducted in a major institute. Methods: This is a retrospective review of research proposals submitted to the IRC of IOM from May 2019 to April 2021. The analysis focused on the institutional/departmental affiliation of investigators, gender of the principal investigator (PI), funding sources, ethical issues, types of proposals, and research design. Results: Out of 769 proposals submitted, seven were rejected (acceptance rate of 99.1%). There was a steady increase in the number of submissions over the study period. Descriptive cross-sectional studies were the most frequent 630 (82.6%) followed by randomized controlled trials. More than half [403, 52.9%] proposals were related to health promotion. The clinical departments contributed 443 (58.1%) submissions. Males outnumbered females (54.2% vs 45.8%) and only 53 (7.0%) were funded. Conclusions: Cross-sectional studies with a focus on health promotion were the most common submissions for ethical approval at the IOM. Policymakers in our institute and other institutions can use this research to set priorities for promoting research. Keywords: Ethical review, Institutional Review Board, Researchers, research proposalPublication Publication Status of Theses among Post-graduate Students in Nursing from Institute of Medicine(Nepal Health Research Council, 2024) Khatri, Pratima; Chapagain, Bigya; Sharma, Mohan RajBackground: Publication of the research work done during the master’s program is highly desirable. However, there is a paucity of data on the number of publications, especially from low-income countries. The objective was to find out the status of the publication of the theses of post-graduate students in Nursing from the Institute of Medicine, Tribhuvan University, Nepal from 2015-2019. Methods: Cross-sectional analytical design with a structured interview via telephone was done for data collection. Independent variables were age, marital status, current work status, current working organization, type of research, year of graduation, and facilitators and barriers to publication, whereas dependent was the publication status of the thesis. Results: Two hundred five (76.2%) out of 269 participated in the study. The age group ranged from 27 to 50 years (mean ± SD = 36.6±4.8). The majority 89.3% were married. Currently working in academic institutions was 51.7%. One hundred ninety-eight (96.6%) respondents performed a cross-sectional descriptive study. Only 2.9% of studies were cross-sectional analytical and 0.5% were qualitative. Seventy-five (36.6%) respondents published their theses. Twenty-seven (36.0%) were published in PubMed-indexed journals. The most common facilitator for publication was academic satisfaction [59 out of 75(78.7%)] followed by encouragement from supervisors 52.0% and peers 40.0%, whereas the commonest barrier to publication was lack of interest [80 out of 124 (64.5%)] followed by lack of confidence 51.6%. Conclusions: Based on the results, more than one-third of the participants published their theses in national and international journals including those indexed in PubMed. Provision of university research grants, development of publication culture among post-graduate students, and making a provision of academic publication before degree awards should be encouraged for more academic publication. Keywords: Journals; Nepal; nursing; publication status; thesis.Publication Publication Status of Theses among Post-graduate Students in Nursing from Institute of Medicine(Nepal Health Research Council, 2024) Khatri, Pratima; Chapagain, Bigya; Sharma, Mohan RajBackground: Publication of the research work done during the master’s program is highly desirable. However, there is a paucity of data on the number of publications, especially from low-income countries. The objective was to find out the status of the publication of the theses of post-graduate students in Nursing from the Institute of Medicine, Tribhuvan University, Nepal from 2015-2019. Methods: Cross-sectional analytical design with a structured interview via telephone was done for data collection. Independent variables were age, marital status, current work status, current working organization, type of research, year of graduation, and facilitators and barriers to publication, whereas dependent was the publication status of the thesis. Results: Two hundred five (76.2%) out of 269 participated in the study. The age group ranged from 27 to 50 years (mean ± SD = 36.6±4.8). The majority 89.3% were married. Currently working in academic institutions was 51.7%. One hundred ninety-eight (96.6%) respondents performed a cross-sectional descriptive study. Only 2.9% of studies were cross-sectional analytical and 0.5% were qualitative. Seventy-five (36.6%) respondents published their theses. Twenty-seven (36.0%) were published in PubMed-indexed journals. The most common facilitator for publication was academic satisfaction [59 out of 75(78.7%)] followed by encouragement from supervisors 52.0% and peers 40.0%, whereas the commonest barrier to publication was lack of interest [80 out of 124 (64.5%)] followed by lack of confidence 51.6%. Conclusions: Based on the results, more than one-third of the participants published their theses in national and international journals including those indexed in PubMed. Provision of university research grants, development of publication culture among post-graduate students, and making a provision of academic publication before degree awards should be encouraged for more academic publication. Keywords: Journals; Nepal; nursing; publication status; thesis.Publication World Health Organization Tool for Benchmarking Ethics Oversight of Health-Related Research with Human Participants(Nepal Medical Association, 2024) Ghimire, Namita; Basnet, Rojina; Acharya, Richa; Adhikari, Santoshi; Verma,Shashi; Sharma, Mohan RajAbstract Benchmarking ethics oversight is a process of aligning comparing and evaluating the strengths and room for improvement of ethical review and approval process across different institutions or the country. The World Health Organization tool for benchmarking ethics oversight is designed to help countries assess and improve their systems for ethically overseeing health-related research involving human participants. It identifies gaps in legal frameworks, committee structures, resources, accountability and transparency while promoting best practices and policy alignment. Nepal has made progress through the research regulations body like the Nepal Health Research Council , but challenges such as inconsistent implementation, oversight of the implementation and resource limitations remain. The tool offers an opportunity to strengthen Nepal’s health research governance and regulation but it must be adapted to fit local contexts, emphasizing accountability, transparency, capacity-building, and improved communication.