Browsing by Author "Sharma, Rajeev"
Now showing 1 - 2 of 2
Results Per Page
Sort Options
Publication A Cross Sectional Study to Assess Peak Expiratory Flow Rate in Healthy School Children for Establishment of Normative Data(Nepal Paediatric Society (JNPS), 2020) Sharma, Rajeev; Kaur, Avneet; Gupta, Manish; Kaur, Amarpreet; Arora, Hobinder; Singh, SukhpalAbstract: Introduction: Peak Expiratory Flow Rate (PEFR) can be measured by cheap and portable instrument, peak flowmeter which is useful in detecting early asthmatic changes and monitoring the treatment response. Methods: This study was conducted on 1000 normal healthy children of nine to 14 years of age of either sex from various schools of Faridkot district in South West Punjab, India. Anthropometry was done and PEFR was measured using Mini Bell Peak Flow Meter. Linear regression analysis was done and normograms were constructed. Results: Linear regression equations were derived for PEFR with height, weight, BSA and BMI in boys and girls. The most significant correlation was seen with height (r = 0.527 in boys, r = 0.410 in girls) followed by body surface area (r = 0.506 in boys, r = 0.296 in girls). Body mass index had negative correlation (r = -0.200) with PEFR in girls. Nomograms were constructed on basis of linear regression equations of PEFR with height (-46.67 + 2.02 x height for boys, -12.64 + 1.50 x height for girls) and BSA (82.02 + 137.2 x BSA for boys, 96.61 + 88.11 x BSA for girls) Conclusion: There is need for nomogram for each region so that personal value of PEFR can be compared to normal reference population and also with predicted value from regression equation as PEFR varies from region to region. The nomograms and regression equations derived from this study can be useful for predicting normal values of PEFR of children of South West Punjab.Publication Outcome of Epidermal Growth Factor Receptor Mutated and Non Mutated Adenocarcinoma Lung to Standard Therapy(Nepal Health Research Council, 2023) Dulal, Soniya; Mishra, Akshat; Shah, Aarati; Acharya, Bibek; Shilpakar, Ramila; Sandhya, Chapagain, Acharya; Karn, Ambuj; Sharma, Rajeev; Gautam, Balram; Paudel, Bishnu DuttaAbstract Background: Asian patients with adenocarcinoma of lung have higher incidence of epidermal growth factor receptor mutations which predict increased response and survival in patients to oral tyrosine kinase inhibitors. This study was conducted to study the frequency of epidermal growth factor receptor mutation in patients in Nepal and compare the outcome in epidermal growth factor receptor mutated versus non-mutated patients receiving standard therapy. Methods: This is an observational study conducted among newly diagnosed patients with stage IV adenocarcinoma of lung in Bir Hospital from April 2017 to June 2018. Demographic and clinical data collection along with epidermal growth factor receptor mutation testing was done. Patients with epidermal growth factor receptor mutations received Gefitinib while non-mutated patients received systemic chemotherapy. Response evaluation, progression free survival at 1 year, objective response rate and quality of life were compared. Follow up period was for 1 year. Results: Eighty three (33%, n=253) patients were diagnosed with adenocarcinoma of the lung with mean age at diagnosis being 59.4 years. epidermal growth factor receptor mutations were found in 29% patients. Complete response was achieved in 9.1% vs 3.0 % (p=0.46), objective response rate was 27.3% versus 15.2% (p=0.23), progression free survival at 1 year was 39% vs 27%, (p = 0.29) and mean score of global health status was 68.1 versus 61.6 in epidermal growth factor receptor mutated versus non-mutated (p = 0.036). Conclusions: The frequency of epidermal growth factor receptor mutation in patients with adenocarcinoma of the lung was lower than in Eastern Asian studies, but higher than in western populations. epidermal growth factor receptor mutated patients had improved survival, better treatment response and quality of life in comparison with non-mutated. Keywords: Adenocarcinoma of lung; EGFR; quality of life