Browsing by Author "Shrivastav, Shreya"
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Publication Diagnostic Accuracy of Fine Needle Aspiration Cytology as Compared to Histopathology in Parotid Gland Swelling(Nepal Health Research Council, 2023) Tripathi, Prashant; Acharya, Kunjan; Shrivastav, Shreya; Gyawali, Bigyan RajAbstract Background: The diagnosis of parotid swelling is challenging and investigations like imaging and needle aspiration cytology are helpful. The objective of this study was to determine the diagnostic accuracy of fine needle aspiration cytology (FNAC) as compared to the histopathology in parotid gland swelling. Methods: It was a descriptive cross sectional study carried out in the Department of ENT-Head & Neck Surgery, Tribhuvan University Teaching Hospital, Institute of Medicine, Kathmandu by reviewing the medical record charts of the patients who had undergone surgery for parotid lesions during the study period of seven and half years. All patients whose fine needle aspiration cytology and histopathology reports were available were included in the study. The data were presented as mean, standard deviation, ratio and percentages. Microsoft excel was used for data analysis. Results: There were 75 patients included in the study. The age ranged from nine years to 78 years and the mean age being 38.3± 17.42 years. The male to female ratio was 1:1.78. The concordance rate between fine needle aspiration cytology and histopathology was 82.7%. The sensitivity and specificity of the fine needle aspiration cytology were 80% and 95% respectively. Similarly, the positive predictive and negative predictive values were 84% and 93% respectively. The diagnostic accuracy of the fine needle aspiration cytology was 91% for the parotid swelling in our study. Conclusions: The diagnostic accuracy of fine needle aspiration cytology for parotid swellings in our study was excellent. The result of fine needle aspiration cytology is helpful in deciding management plan for parotid lesions. Keywords: Benign; cytology; histopathology; malignant; parotid.Publication Morphological and Immunophenotyping Profile of Acute Leukemia: A Study from a Tertiary Level Hospital in Nepal(Rapti Academy of Health Sciences (RAHS), 2024) Bishowkarma, Sabita; Bishowkarma, Sabita; Shrestha, Anjan; Shrivastav, Shreya; Rasaily, SureshAbstract: Introduction: Acute leukemia is a heterogeneous disorder necessitating a multidisciplinary diagnostic approach. Flow cytometry is essential for lineage assignment and maturation stage identification. This study aims to determine the frequency and immunophenotyping of acute leukemia at Tribhuvan University Teaching Hospital (TUTH). Methods: Conducted from January 2020, to December 2021, this cross-sectional study analyzed 504 bone marrow aspiration samples. Among these, 97 (19.2%) cases were identified as acute leukemia. Patient demographics, morphology, and immunophenotyping features were recorded and analyzed. Results: Of the acute leukemia cases, 66% were male and 34% female. The pediatric population comprised 62.9%, while adults made up 37.1%. Cytochemical staining was performed in 92 cases, revealing 67% as acute lymphoblastic leukemia (ALL) and 33% as acute myeloid leukemia (AML). Flow cytometry was conducted on 84 cases, leading to diagnoses of 30 AML, 45 B-ALL, and 9 T-ALL. Conclusion: Acute leukemia can affect all age groups with male preponderance. ALL is more prevalent in children, while AML is more common in adults. Immunophenotyping is critical for the classification and subtyping of acute leukemia, enhancing diagnostic accuracy and guiding treatment strategies.