Browsing by Author "Sijapati, Karuna Singh"
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Publication A Middle-Aged Female with Multiple Brownish Plaques and Nodules: A Case Report of Multiple Cutaneous Reticulohistiocytomas(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2018) Sijapati, Karuna Singh; Karki, Sudha; Karki, SmritiAbstract: Non-Langerhans-Cell histiocytosis spectrum of disorders includes multicentric reticulohistiocytosis (MR) and multiple cutaneous reticulohistiocytomas (MCR), which are very uncommon granulomatous conditions. In reticulohistiocytoma, the most common sites of involvement are extensor surfaces, particularly the hands and forearms and the classical lesions are characterised by firm brown or yellow papules, nodules and plaques. As MCR is a very rare granulomatous condition, we report here a middle-aged female a case of MCR and we highlight the significance of considering reticulohistiocytoma in the differential diagnoses of chronic and persistent brownish plaques or nodules on skin. Keywords: Azathioprine, cyclophosphamide, histiocytes, histiocytosis, non-langerhans-cellPublication Cutaneous Manifestations of Thyroid Hormone Disorder(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2019) Sijapati, Karuna Singh; Rijal, Arpana; Agrawal, Sudha; Khadka, Dhan Keshar; Maskey, RobinAbstract: Introduction: Thyroid hormone disorder (THD), a major health problem, is associated with a wide range of diseases. One of the organs, which shows this wide range of clinical signs is the skin. Some dermatological findings may be the first symptoms of THD. Therefore, this study was planned to determine various cutaneous manifestations of THD that can be used as a diagnostic marker for THD. In Nepal due to lack of awareness, thyroid diseases may go unnoticed .So, cutaneous manifestations help in early diagnosis and treatment of THD. Objectives: To identify cutaneous manifestations of THD and to evaluate dermatological manifestations specific for THD. Materials and methods: Seventy six patients with diagnosis of THD attending endocrine clinic of Internal Medicine Department in BPKIHS, Dharan were consecutively assessed for cutaneous changes by detailed history and clinical examination. As a control group, 26 age and sex matched individuals without THD were included to assess frequency of cutaneous manifestation in normal individuals. Results: Fifty five (72.3%) cases and 4(15.4%) control had skin changes. This observation was statistically significant with OR-14.4(95% CI4.43 – 46.78) and p<0.001.Hair changes (OR-2.100, 95% CI 0.647-6.821 and p=0.210) and nail changes (OR-1.818, 95% CI 0.371-8.902 and p=0.726) had no statistically significant association with THD. Conclusion: THD may present as or be associated with many changes in skin, hair and nails. Keywords: Cutaneous changes, Hypothyroidism, Hyperthyroidism