Browsing by Author "Thapa, Sangita"
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Publication Home / Archives / Vol. 61 No. 265 (2023): JNMA: Published Monthly / Original Article Transaminitis among Patients with Dengue Fever Visiting a Tertiary Care Centre(Nepal Medical Association, 2023) Rayamajhi, Rabindra Jang; Thapa, Sangita; Rayamajhi, Prachi; Maharjan, Suman; Yadav, Roshan Kumar Ray; Roka, KumarAbstract Introduction: Transaminitis is a condition where serum aspartate transaminase and alanine transaminase increase indicating liver dysfunction. One such disease where liver involvement might be observed is dengue, which is a mosquito-borne viral infection. The aim of the study was to find out the prevalence of transaminitis among patients with dengue fever in a tertiary care centre. Methods: A descriptive cross-sectional study was conducted in a tertiary care centre from 1 November 2022 to 31 March 2023 after obtaining ethical approval from the Institutional Review Committee. Informed written consent was taken before collecting the data. A rapid immunochromatography test was used to confirm dengue infection. Serum aspartate transaminase and alanine transaminase were measured through routine Reitman and Frankel’s enzymatic method. Dengue-confirmed patients from the medical outpatient department, fever clinic, and medical ward of the centre were included in the study. Patients with known prior liver diseases or any other chronic diseases, pregnancy, and patients in the hospice unit were excluded. Convenience sampling method was used. The point estimate was calculated at a 95% Confidence Interval. Results: Among 442 dengue infected patients, the prevalence of transaminitis was 188 (42.53%) (37.92-47.13, 95% Confidence Interval). The highest frequency of dengue positive was observed among the 18-35 years age group, which was 97 (51.59%) with male predominance 134 (71.27%). Conclusions: The prevalence of transaminitis among patients with dengue fever in a tertiary care centre was found to be lower than other studies done in similar settings.Publication Impact of COVID-19 Pandemic on Pregnant Mothers(Institute of Medicine, 2022) Kapali, Gayetri Darshandhari; Koirala, Manisa; Katuwal, Neeta; Thapa, Sangita; Adhikari, Anuradha; Gachhadar, Rashmi; Neupane, Sharmila; Panta, GangaABSTRACT Introduction: The COVID pandemic has detrimental impact on physical and psychological wellbeing of expectant mothers. Fear and worry during pregnancy amplifies risks and can have negative physical and psychological consequences for mother and newborn outcomes. So this study intended to assess the impact of COVID-19 pandemic on pregnant mothers during pregnancy. Methods: Descriptive cross-sectional study design was applied among 123 pregnant mothers who visited antenatal OPD of Tribhuvan University Teaching Hospital. Data were collected through non-probability purposive sampling technique by using interview schedule. Descriptive statistic and inferential statistics were used to analyze the collected data. Results: Pregnant mothers faced difficulties to maintain physical wellbeing, 84 (68.3%) did not perform any physical exercise, 96 (78%) were physically inactive, 107(87%) stated absence of sound sleep during pregnancy. Majority i.e. 111 (90.2%) of pregnant mothers perceived fear on outcome of newborn. Likewise, 11(8.9%) had severe impact on their psychological wellbeing during COVID-19 pandemic. Place of residence, number of children and trimester of pregnancy were found to be the strong predictors of psychological impact among pregnant women. Conclusion: The impact was seen on exercise, sleep, physical wellbeing whereas pregnant mothers seemed more attentive on healthy diet. They expressed more fear on obstetric or newborn outcome and uncertainty on mode of delivery with this panic situation. Keywords: COVID-19, impact, mothers, pandemic, pregnancy