Journal Issue: Volume: 30, No. 1, April, 2008
Loading...
Volume
Number
Issue Date
2008
Journal Title
Journal ISSN
ISSN (Print) : 1993-2979 | ISSN (Online) : 1993-2987
Journal Volume
Articles
Effect of Acute Appendicitis on routine Liver Function Tests
(Institute of Medicine, 2008) Khan, S
Abstract
Background: Liver plays a central role in metabolism and host defense mechanism. It is the first organ to receive substances absorbed or microorganism translocated from gastro intestinal tract (GIT). The aim was to evaluate the effect of acute inflammation of appendix on routine liver function test.
Method: 50 cases with no history of hepatotoxic drug intake, non –alcoholic or alcoholic with AST (SGOT)/ALT (SGPT)<2, hepatitis B surface antigen (HBsAg) negative and no past history of jaundice with acute appendicitis were studied.
Result: Among 50 cases 49 cases were of acute appendicitis and its complications. Serum bilirubin was raised in 87.7% cases. It was mixed type in majority (84.6%) of the cases. The average level of serum bilirubin was 2.34 mg/dL. Serum Alanine Amino Transferase (ALT) was normal in 73.46% of the cases where as elevated in 26.54% of the case. Aspertate. Age and sex adjusted alkaline phosphatase (ALP) was normal in 51.2% of the cases where as it was elevated in 48.98% of the cases. Amino Transferase (AST) was normal in 61.22% cases whereas elevated in 38.77% of the cases
Conclusion: There was mixed type of hyperbilirubinemia and that was due to dysfunction rather than damage of the hepatocyte. This might be due to combined effect of depressed hepatocellular uptake of unconjugated bilirubin and excretion of the conjugated bilirubin by bacteria, their toxins or cytokines. The elevation of AST and ALP is of no diagnostic value where as elevation (≥1times) of ALT can be helpful to rule out acute inflammation of appendix at 95% level of confidence in clinically suspected cases of acute appendicitis.
Keywords: Acute Inflammation of Appendix, Acute appendicitis, Hyperbilirubinemia, Routine liver function tests
Congenital anomalies in the rural areas of Kolar District of Karnataka
(Institute of Medicine, 2008) Bilodi, AKS; Gangadhar, MR
Abstract
Introduction: Congenital Anomalies are the birth defects which may be morphological, biochemical or behavior of all births that has been induced during any stages of pregnancy .
Materials and Methods: The objective of the present study is to know the various types of Anomalies the percentages of incidences of Anomalies and to compare and correlate the present study with available literatures. R.L. Jallappa Teaching Hospital of Sri Devraj Urs Medical College, Tamaka, Kolar Karnataka from15.02.2007-15.07.2007-Five Months Study.
Results: Sixty anomalies were observed in live births in the Departments of Surgery and fifteen anomalies in Radiology in the above hospital. The age group of malformations were new born to adult age group. They were seen found 73.00% in males and 27% in females. The overall percentages of incidences of Anomalies in the present study were 2.17%. This study was later compared and correlated with earlier workers and with the available literatures.
Conclusion: Ultrasound can diagnose most of the congenital anomalies.
Keywords: Surgical Anomalies Still births and Congenital Malformations
Dexamethasone Cyclophosphamide Pulse Therapy in Dermatology
(Institute of Medicine, 2008) Parajuli, S; Paudel, U; Pokharel, DB
Abstract
Introduction: The objectives of this study was to: study profile of dermatological disease treated with pulse therapy in TUTH , determine the clinical time to remission of diseases, duration of remission after withdrawal of treatment and determine the side effect profile of the treatment. Materials and
Methods: Demographic profile of the patients treated with pulse therapy for various dermatological conditions, the duration of diseases prior to treatment, the clinical time to remission of diseases, duration of remission after withdrawal of treatment and side effects of treatment. Results: Pulse therapy was received by 12 patients, five patients were SLE (F: M-4:1) with mean age of onset 28.75yrs, six patients were of Pemphigus (F: M-1:1) with mean age of onset 30.6 yrs and there was one 40 yrs old female patient of scleromyxoedema. The mean duration of disease prior to treatment was 2.8 yrs in SLE and 1.4 yrs in Pemphigus. The mean duration of clinical time to remission was 4 months for SLE while only one patient of Pemphigus had received clinical remission after 6 months. Duration of remission after withdrawal of treatment could not be ascertained because none of them had completed phase III. The main side effects observed in our study were flushing and secondary infection.
Conclusion: DC pulse therapy appears to be encouraging treatment in the treatment of dermatological conditions like SLE, Pemphigus and scleromyxoedema. However study involving a large number of patient and long duration of follow up is needed before considering it as best treatment available for treatment of these conditions.
Keywords: Dexamethasone cyclophsophamide pulse, Pemphigus, SLE, Scleromyxoedema
Calculation of Body Mass Index: Proxy for Prevention of Multiple Disease Syndrome
(Institute of Medicine, 2008) Joshi, S
Abstract
Introduction: A mini health survey was conducted to assess the Body Mass Index (BMI) score among 240 respondents who had attended Golden Jubilee Celebration of Maharajgunj Nursing Campus (2006). Materials and Methods: Along with structured interview schedule, health histories, anthropometric measurement (height and weight), and blood pressure were checked among the respondents.
Result: The study findings revealed that majority of the respondents were current nursing students below 40 years of age, among them 56 % of them had normal BMI score (18.5 - 24.9); while 44 % had abnormal BMI score (> 18; and above 25.0). Among the respondents who had BMI score, 29 % were overweight (> 25.0 - 29.9), and 4 % were obese (> 30); while remaining 11 % had less than normal BMI score (<18). Among the overweight respondents who were above 40 years of age, 17 % had hypertension and 4 % had diabetic mellitus. Majority of the respondents who were above 40 years of age had multiple diseases particularly hypertension and diabetes mellitus than those below 40 years of age with normal BMI scores.
Conclusion: This study finding highlights the need of launching awareness raising programmes for the prevention and early detection of multiple diseases among the aged population particularly with high BHI score. It is also recommended to schedule regular health screening programmes incorporating calculation of BMI among the adult population.
Keywords: Body Mass Index (BMI), Multiple Disease Syndrome, Hypertension, Diabetes Mellitus