Journal Issue: Volume: 16, No. 1 (2018)
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Volume
Number
Issue Date
2018
Journal Title
Journal ISSN
ISSN 2091-0231 eISSN 2091-167X
Journal Volume
Articles
Cutaneous Leishmaniasis: Revisited
(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2018) Neupane, Saraswoti
NA
Periorbital Hyperpigmentation: Overcoming the Challenges in the Management
(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2018) Agrawal, S.
NA
Keywords: Dermatology curriculum
A Clinical Study of Steroid Induced Dermatoses
(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2018) Parajuli, Sudip; Paudel, Upama; Poudyal, Amod Kumar; Pokhrel, Dinesh Binod
Abstract:
Introduction: Steroid induced dermatoses on face are one of the common presentations in Dermatological practice.
Objectives: 1) Understand the clinical patterns of adverse effects of long term abuse of topical steroid on face and 2) Assess the factor which promotes its abuse.
Materials and Methods: This was a descriptive exploratory cross-sectional study carried out from December, 2013 through November, 2014. A total of 39 patients fulfilling the inclusion criteria were enrolled into the study. All the study variables were recorded using preformed structured questionnaire and analyzed.
Results: The following effects of steroid abuse on face were seen: pruritus (38.5%), burning (15.4%), eythema (74.4%), telangiectasias (66.7%), acneiform eruptions (59%), comedones (35.9%), xerosis (55.1%), photosensitivity (51.3%), rebound phenomenon (38.5%) and others (38.5%). Most of them used steroids on recommendation of their friends (38.5%) and pharmacists (20.5%). All of them used steroid for different dermatoses on their face.
Limitations: This is a hospital-based small-scale study and might not be true picture of problem in the community.
Conclusion: Long term use of steroid on face results in different clinical presentations. Most of the patients used steroid
on recommendation of their friends facilitated by easy availability of the drug over- the -counter.
Keywords: Comedones, erythema, non prescription drugs, papules, pustules, rosacea, steroids
Association of Androgenetic Alopecia with Benign Prostatic Hyperplasia: A Case Control Study
(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2018) Chaudhary, Manoj Kumar; Agrawal, Sudha; Agrawal, Chandra Shekhar
Abstract
Introduction: Androgenetic alopecia (AGA) is associated with increased risk of several systemic diseases and some environmental factors, however, controversies exist. Since AGA and Benign Prostatic Hyperplasia (BPH) share common pathogenesis and AGA manifests some decades before BPH onset, it may serve as an early marker of BPH.
Objective: This study was conducted to know AGA and its association with BPH in men ≥20 years of age.
Materials and Methods: Clinically diagnosed cases of AGA (n=176) and 117 age matched healthy controls were enrolled. All cases and controls were subjected for abdomino-pelvic ultrasonography, urinary flowmetry, fasting lipid profiles, glycemic index and body mass index. International Prostate Symptom Score (IPSS) was also assessed.
Results: Among 176 patients, 120 (68.18%) had Hamilton-Norwood grade III AGA and 56 (31.82%) had grade IV-VII AGA. In both groups, 140 (79.55%) cases and 93 (79.49%) controls were aged <35 years respectively. Family history of AGA was present in 108 (61.36%) cases and 2 (1.71%) controls. This observation was statistically significant with OR= 89.61 (95%CI 23.67-339.29). Three (1.7%) cases and none of the controls had prostate volume >30ml. Seventeen
(9.66%) cases and 4 (3.42%) controls were graded as moderately/severely symptomatic IPSS. Statistically significant association was seen between family history and early onset of hair loss (<35 years) in a male sibling or parent.
Conclusion: Although positive family history was associated with early onset of AGA, no association between AGA and BPH could be elicited in our study.
Keywords: Alopecia, body mass index, glycemic index, lipids, prostatic hyperplasia
Efficacy and safety of neem seed extract compared with clotrimazole in tinea corporis/ cruris: A randomized controlled trial
(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2018) Poudel, Isha; Amelia, Elizabeth; Tianco, V.; Villafuerte, Lillian L.
Abstract:
Introduction: Tinea corporis and tinea cruris are common superficial fungal infections. Neem (Azadirachta indica) seed extract has shown antifungal properties in vitro, but no clinical studies have been done for superficial dermatophytoses. This study compared the efficacy and safety of 5% neem seed extract in cream base with 1% clotrimazole cream when used twice daily for four weeks, in the treatment of localized tinea corporis and/or tinea cruris.
Materials and Methods: This is a randomized, double blind, clinical trial. Patients with localized tinea corporis and/or tinea cruris were evaluated at baseline, week 1, week 2 and week 4. Clinical, mycological and effective cure rates of both treatment groups were determined. The patients’ post treatment overall satisfaction scores and the incidence of adverse effects were also documented.
Results: Sixty patients were recruited, and 30 patients were randomized to each treatment arm. There were no significant differences in post treatment scores (p value=0.221). Effective cure, defined as the combination of marked clinical improvement and mycological cure, was seen in 20/30 (66.67%) in the neem seed extract group and 24/30 (80%) in the clotrimazole group (relative risk = 1.67, 95% confidence interval = 0.69 – 4.0). Post treatment overall satisfaction scores were comparable (p value = 0.333). Two patients experienced adverse effects in the neem seed extract group, while there were no adverse effects in the clotrimazole group.
Conclusion: Efficacy and safety of 5% neem seed extract in cream base is comparable to 1% clotrimazole cream for the treatment of localized tinea corporis and/or tinea cruris.
Keywords: Azadirachta, clotrimazole, ergosterol, potassium hydroxide, seed, tinea