Journal Issue: Volume: 13, No. 1 (2015)
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Volume
Number
Issue Date
2015
Journal Title
Journal ISSN
ISSN 2091-0231 eISSN 2091-167X
Journal Volume
Articles
Communication Ethics in Dermatology
(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2015) Pokhrel, Dinesh Binod
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Recent advances in Immunobullous diseases
(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2015) Bhari, N; Verma, K K
Abstract
The researches in the recent past have led to better understanding of pathogenesis, diagnostic methods and treatment of autoimmune bullous diseases. Significant advances in our understanding of pathogenesis of pemphigus have resulted in development of multiple pathogenic models and discovery of new signalling pathways involved in its pathogenesis. Various newer clinical variants have been described and diagnostic methods have been developed. Disease activity scoring methods in pemphigus provide comparable and interpretable results which facilitate better understanding of disease activity and assessment of treatment response. Use of biological agents have led to better control of disease activity and other newer therapeutic options are being explored.
Keywords: Immunobullous diseases, Recent advances, Pathogenesis, Diagnosis, Scoring, Treatment
Comparison of clotrimazole 1% cream with 50% tea tree oil extract in a cream base for the treatment of tinea corporis/cruris: A randomized controlled trial
(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2015) Pokharel, Achyut; Yaptinchay, C; Thaebtharm, A E
Abstract
Background: Tinea cruris and corporis are common diseases and can be widespread. Estimated lifetime probability of contracting the disease is as high as 10-20%. Dermatophytic infections are one of the three most frequently observed skin diseases among poor communities in tropical countries. Tea tree oil exerts its antifungal activity by altering membrane properties and compromising membrane associated function resulting in clinical improvement and mycological cure of superficial dermatophytes.
Objectives: The aim of this study is to determine the efficacy and safety of tea tree oil 50% in a cream base compared with clotrimazole 1% cream for the treatment of tinea corporis or cruris.
Material and Methods: Sixty patients were enrolled in the study and randomized into tea tree oil and clotrimazole groups with 30 patients in each group. Both groups were instructed to apply cream two times a day after cleaning with soap for 4 weeks. The patients were asked to follow-up every 2 weeks for photography, microscopic and clinical assessment. Before enrollment, patient signed a written consent form.
Results: Using intention to treat analysis, the assessment of mycological cure, clinical cure, global physician assessments and overall patient perception were done. There were no statistical difference of all the parameters between tea tree oil group and clotrimazole group.
Conclusion: Tea tree oil 50% cream is safe and as effective as clotrimazole 1% cream for the treatment of tinea corporis or cruris.
Keywords: Tinea corporis, Tea tree oil, Dermatitis
Acrochordons and diabetes mellitus: A Case control study
(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2015) Shrestha, Pratistha; Poudyal, Y; Rajbhandari, S L
Abstract
Background: Acrochordons (Skin tags) are common benign skin tumors usually occurring on the neck and major flexors of older people. These range in size from 1 mm to 1cm in diameter and are skin colored or brownish. A possible association with diabetes mellitus has been suggested in previous studies, but the result is not conclusive.
Objectives: The aim of this study was to find out the association of diabetes mellitus with acrochordons.
Material and Methods: One hundred and two patients were selected for the study. Among them 51 (males-23 and females-28) with acrochordons were taken as cases and 51 with other dermatologic disease after matching age and sex were taken as controls. The patients were selected from OPD of Department of Dermatology and Venereology in Universal College of Medical Sciences - Teaching Hospital (UCMS-TH). Blood glucose level including both fasting plasma glucose and 2-hour post-glucose load were determined for both case and control and compared.
Results: Patients with acrochordons had significantly higher frequency of diabetes than the control group (p<0.001). Total of 48.5% and 40% of patients with acrochordons having diabetes were obese and overweight respectively.
Conclusion: There is an increased risk of diabetes mellitus in patients with acrochordons. With regard to the importance of early diagnosis of diabetes, it is recommended a high level of suspicion for diabetes mellitus in patients with acrochordons.
Keywords: Acrochordons, Diabetes mellitus, Skin tags
Study of pregnancy dermatoses in patients attending outpatient of B P Koirala Institute of Health Sciences, Dharan, Nepal
(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2015) Bastola, Prabha Dawadi; Rijal, A; Upreti, D
Abstract
Background: Pregnancy causes immense hormonal, vascular and immunologic changes affecting every organ system including skin. It can have a positive as well as a negative effect on the course of pre-existing skin diseases. Specific dermatoses of pregnancy constitute a heterogenous group of inflammatory dermatoses associated exclusively with pregnancy.
Objectives: To study the spectrum and frequency of pregnancy dermatoses and to compare the clinico- epidemiological profile of non-specific dermatoses among pregnant versus non-pregnant women of reproductive age.
Material and Methods: This descriptive hospital based study recruited 300 patients with skin lesions; the test group comprised 150 pregnant ladies while the control group comprised 150 non-pregnant female of reproductive age. Demographic characteristics, medical history, examination findings, and relevant investigation reports were noted and diagnosis established. The patients of test group were then classified into distinct subgroups of dermatoses and were compared with non-pregnant patients of control group.
Results: Specific dermatoses of pregnancy was very common (41.33%) in our study among which Prurigo of pregnancy was the commonest (24%). Inflammatory lesions were predominant in pregnant group (57.33%, p=<0.001) whereas infectious diseases were predominant in the non-pregnants (44.67%). The demographic variables had no significant role in determining the distribution of any of the skin lesions in this study.
Conclusion: Inflammatory lesions mostly specific dermatoses of pregnancy are found to be the commonest skin lesions among the pregnant ladies whereas infectious diseases are found to be comparable among pregnant and non pregnant ladies in our study.
Keywords: Infectious dermatoses, Pregnancy dermatoses, Prurigo of pregnancy