Assessment of Thyroid Dysfunction During Different Trimester of Pregnancy

dc.contributor.authorPrajapati, Sunita
dc.contributor.authorPrajapati, Gayatri
dc.contributor.authorShrestha, Vikram
dc.contributor.authorShrestha, Sujata
dc.date.accessioned2024-03-24T05:22:33Z
dc.date.available2024-03-24T05:22:33Z
dc.date.issued2022
dc.descriptionOriginal Articleen_US
dc.description.abstractAbstract Background: Thyroid dysfunction is frequently seen in pregnant women and is associated with complications like miscarriage, gestational hypertension, placental abruption, pre mature delivery and fetal growth retardation and even causes impaired neuropsychological development of fetus. This study is carried out to assess the prevalence of thyroid disorder during different trimester of pregnancy. Methods: Serum samples were collected from 124 pregnant women attending Patan Academy of Health Science for ante natal visit. Free thyroxine free triiodothyronine and thyroid stimulating hormone were performed by chemiluminescent assay. Results: Out of 124 pregnant women, euthyroidism was seen in 79% (n =98) followed by subclinical hypothyroidism (10%, n=13) and primary hypothyroidism (8%, n=10). Subclinical hyperthyroidism and primary hyperthyroidism accounts for 1% (n=1), and 2% (n=2) respectively. Although, thyroid disorder was found to be more prevalent in third trimester (38.4%, n=10) but the distribution in first and second trimester (34.6%, n= 9, 27%, n= 7 respectively) were also significant. Mean fT3 and fT4 level were found to be negatively correlated with trimester (r=-0.19, p=0.027 and r=-0.29, p=0.001 respectively) whereas positive correlation of trimester was seen with TSH (r=0.08, p=0.35). Conclusions: Hypothyroidism is more common in pregnant women visiting tertiary care hospital. Different complication can be minimized if diagnosis is done early. Keywords: Hypothyroidism; pregnant; thyroid stimulating hormone; trimester, gestational weeken_US
dc.identifier.citationPrajapatiS., PrajapatiG., ShresthaV., & ShresthaS. (2023). Assessment of Thyroid Dysfunction During Different Trimester of Pregnancy. Journal of Nepal Health Research Council, 20(4), 830-833.en_US
dc.identifier.issnPrint ISSN: 1727-5482; Online ISSN: 1999-6217
dc.identifier.urihttps://hdl.handle.net/20.500.14572/71
dc.language.isoenen_US
dc.publisherGovernment of Nepal; Nepal Health Research Council; Ramshah Path, Kathmandu, Nepalen_US
dc.relation.ispartofseriesOct-Dec, 2022;3712
dc.subjectHypothyroidismen_US
dc.subjectPregnanten_US
dc.subjectThyroid stimulating hormoneen_US
dc.subjectTrimesteren_US
dc.subjectGestational weeken_US
dc.titleAssessment of Thyroid Dysfunction During Different Trimester of Pregnancyen_US
dc.typeJournal Articleen_US

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