Browsing by Author "AK, Khanna"
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Publication Isolated tuberculosis of testis(Kathmandu University, 2006) M, Biswas; R, Rahi; SK, Tiwary; R, Khanna; AK, KhannaIsolated epididymo-orchitis is an uncommon presentation of tuberculosis. We report a case of left sided epididymo- orchitis and scrotal involvement due to tuberculosis in a young male patient. The diagnosis was suspected on clinical examination of scrotum and confirmed by FNAC of scrotal and testis. Patient improved after taking antitubercular treatment. Key words: infection, scrotum, treatmentPublication Leiomyosarcoma of stomach: A case report(Kathmandu University, 2006) M, Biswas; R, Rahi; SK, Tiwary; AK, Khanna; R, KhannaWe report a rare case of leiomyosarcoma of stomach infiltrating into the spleen and tail of pancreas, which presented at the age of 28 years of age with haematemesis and was diagnosed after exploratory laparotomy. En block excision of tail of pancreas, spleen and part of the greater curvature of stomach containing the mass was done. Key words: Leiomyosarcoma, Leiomyoma, StomachPublication Lipid peroxidation and antioxidant enzyme status in oral carcinoma patients(Kathmandu University, 2005) R, Khanna; PB, Thapa; HD, Khanna; S, Khanna; AK, Khanna; HS, ShuklaObjective: To measure the lipid peroxidation and endogenous antioxidant enzyme status in oral carcinoma and the protective role of exogenous antioxidants. Meterial and methods: 20 new cases of histologically proven oral squamous cell carcinoma, 20 of leukoplakia and 20 age and sex matched healthy conrols were included. Intra oral pH of patients and controlled were measured by quantitative litmus paper test and serum was analysed for malonialdehyde (MDA), super oxide bismutase (SOD), catalase and glutathione peroxidase (GP). Patients with leukoplakia were treated with exogenous antioxidants for 3 months and the same were reassessed. Results: Oral pH of oral cancer patients was neutral (PH-7) but that of leukoplakia and controls were mildly acidic (6.64 and 6.58 respectively). Serum malonialdehyde levels were highest in oral cancer group. With antioxidant enzymes super oxide bismutase, catalase and glutathione peroxidase different pattern was noticed. Antioxidant enzymes remained almost the same (P > 0.005 each) in patients with leukoplakia after 3 months of vitamin A,C and E. but there was marginal increase in catalase level (P<0.05). Conclusion: This study shows the positive benefit of vitamin (A,C,E) and nutrition supplementation on the antioxidant enzyme defense system hence prevention of oral carcinogenesis in patients with leukoplakia. Keywords: Lipid peroxidation, malonialdehyde, catalase, glutathione peroxidase, superoxide dismutase, oral cancer