Publication: Lipid peroxidation and antioxidant enzyme status in oral carcinoma patients
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Date
2005
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Kathmandu University
Abstract
Objective: To measure the lipid peroxidation and endogenous antioxidant enzyme status in oral carcinoma and the
protective role of exogenous antioxidants.
Meterial and methods: 20 new cases of histologically proven oral squamous cell carcinoma, 20 of leukoplakia and
20 age and sex matched healthy conrols were included. Intra oral pH of patients and controlled were measured by
quantitative litmus paper test and serum was analysed for malonialdehyde (MDA), super oxide bismutase (SOD),
catalase and glutathione peroxidase (GP). Patients with leukoplakia were treated with exogenous antioxidants for 3
months and the same were reassessed.
Results: Oral pH of oral cancer patients was neutral (PH-7) but that of leukoplakia and controls were mildly acidic
(6.64 and 6.58 respectively). Serum malonialdehyde levels were highest in oral cancer group. With antioxidant
enzymes super oxide bismutase, catalase and glutathione peroxidase different pattern was noticed. Antioxidant
enzymes remained almost the same (P > 0.005 each) in patients with leukoplakia after 3 months of vitamin A,C
and E. but there was marginal increase in catalase level (P<0.05).
Conclusion: This study shows the positive benefit of vitamin (A,C,E) and nutrition supplementation on the
antioxidant enzyme defense system hence prevention of oral carcinogenesis in patients with leukoplakia.
Keywords: Lipid peroxidation, malonialdehyde, catalase, glutathione peroxidase, superoxide dismutase, oral cancer