NepMed Repository :: Browsing by Author "Adhikari, P"

Browsing by Author "Adhikari, P"

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COVID 19 Vaccine Breakthrough Infection among Health Care Workers
(Kathmandu University, 2023) Tamrakar, D; Katuwal, N; Adhikari, P; Banjara, M; Shrestha, N; Poudel, P; Shrestha, R
ABSTRACT Background Mass vaccination is considered the primary strategy for reducing the impact of COVID-19, and it has been implemented globally. Objective To study the extent of SARS-CoV-2 infection and breakthrough infection among the HCWs who were fully vaccinated for at least 14 days and investigated the relation between neutralizing antibody response and breakthrough infection. Method This study was a retrospective cohort study among health care workers at Dhulikhel Hospital Kathmandu University Hospital from December 2021 to October 2022. The interviews with semi structured questionnaire were conducted in person or over phone. Out of 1450 participants 137 fully vaccinated HCWs without breakthrough infection were randomly selected for the prospective serological cohort. Result Out of 1079 participants’ majority (51.8%) were of age 25-34 years. Two thirds (66.7%) were females. More than half of participant (54.7%) had infection with SARS-CoV-2 at least once whereas more than one third people (35%) had reported SARS-CoV-2 infection 14 days after receiving full vaccination. Infection after vaccination had less moderate and sever/critical illness and less need for hospitalization as compared to infection before vaccination. Staffs who were directly involved in patient care had higher chance of breakthrough infection compared to those not involved directly in patient care. Those who had prior infection or booster dose had relatively higher antibody level and participants with low level of antibody had higher chance for breakthrough infection (35.3%) than participants with moderate to high level of antibody (11.9%). Conclusion Vaccinations significantly decreased severe diseases and the need for hospitalizations. Breakthrough infection was higher among the health care workers involved in direct patient care and with low level of antibody. KEY WORDS Antibody level, Breakthrough infection, COVID 19, COVID 19 vaccination
Development of a Model One Stop Approach to Post-COVID-19 and other Rehabilitation Conditions
(Kathmandu University, 2024) Adhikari, P; Tamrakar, D; Thakur, C; Shakya, R; Vaidya, N; Acharya, R; Shrestha, J; Byanju Shrestha, I
ABSTRACT Background Post-COVID-19 cases can cause severe disabling symptoms and functional disabilities. WHO recognizes the severity of the condition and publishes a standardised Case Report Form to inform clinical management and public health response. Objective To determine the post-COVID-19 case load. A multidisciplinary team including a diverse team were composed and priority intervention areas were identified through a transdisciplinary approach eventually developing a Model One Stop Approach to post-COVID-19 and other Rehabilitation Conditions. Method The COVID-19 cases recorded at Dhulikhel Hospital were monitored through phone calls to post-COVID-19 complications. Patients were then invited for additional clinical assessments. A diverse team conducted these assessments to identify the needs for expanding a post-COVID-19 clinic and devised rehabilitation services based on predefined criteria. Result A total of 550 respondents were included in the study. The proportion of males (51.7%) was slightly higher than females (48.3%) with the majority of them being Brahmin/Chettri. The primary comorbidities identified were diabetes (10.55%) and hypertension (11.4%). Of the participants, about 50.73% experienced persistent symptoms. About 17.8% reported lasting muscle-related problems, 12.1% had persistent joint pain, and 33% faced temporary cardiac issues. Less than 10% experienced enduring health problems related to vision, hearing, and sleep patterns. Conclusion After COVID-19, patients experienced cardiac and muscle-related issues, increasing morbidity, financial burdens, and pressure on healthcare systems. With the need of sustainable rehabilitation training package, Dhulikhel Hospital serves as a model for a One-Stop Approach to post-COVID-19 and other rehabilitation conditions. KEY WORDS Model, Persistent, Post-COVID-19, Rehabilitation, Symptoms
First Reported Death of a Postpartum Woman Due to Coronavirus Disease 2019 in Nepal: A Lesson Learnt
(Kathmandu University, 2020) Shrestha, AP; Bhushal, N; Shrestha, A; Tamrakar, D; Adhikari, P; Shrestha, P; Shrestha, A; Karmacharya, B; Basnet, S; Tamrakar, SR; Shrestha, R; Shrestha, R
ABSTRACT The first case of coronavirus disease 2019 was reported on December 31, 2019 in Wuhan, China where the average case fatality rate was 6.1 ± 2.9%. There are 453 deaths as of September 24, 2020 in Nepal. We report the first death of a 29-years-old postpartum woman due to COVID-19 in Nepal who was referred from a rural health center to Dhulikhel Hospital. On arrival, she was taken to the acute respiratory zone of the emergency department to provide immediate lifesaving procedures. Despite the repeated resuscitative measures, return of spontaneous circulation could not be achieved. The real time polymerase chain reaction test was positive. Our case report highlights the importance of early clinical suspicion, importance of “safety first” in healthcare settings, and the chain of management in such patients. We consider the fact that a postpartum woman registered as the first case of COVID-19 related death in Nepal to be an area of further study. KEY WORDS Coronavirus, Emergency department, Personal protective equipment, Postpartum death, Real time polymerase chain reaction, Resuscitation
Knowledge and Attitude Regarding Human Milk Banking among Antenatal Mothers Attending Antenatal Clinic
(Kathmandu University, 2024) Dhakal, RD; Upreti, R; Nepal, S; Dahal, BD; Adhikari, P
ABSTRACT Background Breast milk is the ideal food that has essential nutrients for the normal growth and development of infants. It contains antibodies that help to protect against many common childhood illnesses. For infants who cannot receive breast milk from their own mothers, due to maternal illness, death, medication, disability, insufficient milk production, allergies, or prematurity, donated breastmilk can become the ideal option. Objective To assess the knowledge and attitude regarding human milk banking among antenatal mothers. Method A cross-sectional analytical research was conducted among 422 antenatal mothers attending the antenatal outpatient department of Bharatpur hospital from date 04 November to 04 December 2022. Systematic random sampling was used to select the study unit. A semi-structured interview schedule was adopted to collect the data. Collected data were analyzed by using Descriptive statistics as well as inferential statistics. Result Out of 422 mothers, the majority 58.8 % had poor knowledge and 55.9% had a negative attitude toward human milk banking. There was a significant association between poor knowledge and negative attitude with some socio-demographic variables such as age (AOR=2.16; 95%CI= 1.372-3.401; p=0.001), history of adverse pregnancy outcome (AOR =6.202 95% CI=1.786-21.54;p=0.004), occupation (AOR= 1.906; 95% CI = 1.246-2.915; p=0.003). Conclusion It is concluded that the majority of the respondents had poor knowledge and a negative attitude regarding human milk banking.Knowledge and awareness of human milk banking, play a major role to remove misperceptions about human milk donation and banking. Therefore, proper dissemination of information about human milk bank services, is necessary. KEY WORDS Antenatal Clinic, Antenatal mother, Human milk bank, Knowledge and attitude
Knowledge and practice regarding menstrual hygiene in rural adolescent girls of Nepal
(Kathmandu university, 2007) Adhikari, P; Kadel, B; Dhungel, Sl; Mandal, A
Objective: This study was done in the adolescent girls to evaluate the knowledge and practice on different aspects of menstrual hygiene. Methods: One hundred and fifty adolescent girls of age 13-15 years from 3 schools of Shivanagar and Patihani village development committees of Chitwan district were involved in this study. Altogether 27 questions were asked to each of them. Results: During our study, we found that they were not properly maintaining the menstrual hygiene. Only 6.0% of girls knew that menstruation is a physiologic process, 36.7% knew that it is caused by hormones. Ninety-four percentages of them use the pads during the period but only 11.3% dispose it. Overall knowledge and practice were 40.6% and 12.9% respectively. Conclusion: Although knowledge was better than practice, both were not satisfactory. So, the girls should be educated about the process and significance of menstruation, use of proper pads or absorbents and its proper disposal. This can be achieved by giving them proper training and health education (by teachers, family members, health educators, and media) so that there won't be any misconception to the adolescent girls regarding menstrual hygiene. Key words: Menstrual Hygiene, adolescent Girls and Nepal
Knowledge, Attitude and Practice towards COVID-19 among Private School Teachers of Chitwan, Nepal
(Kathmandu University, 2021) Dhakal, RD; Paudel, D; Shrestha, P; Adhikari, P
ABSTRACT Background The coronavirus disease (COVID-19) pandemic has brought life to a standstill across the world, with nearly 178 countries reporting school closures. As the schools have started reopening slowly, precautions are utmost necessary to prevent the potential spread of COVID-19 in school and community settings. Objective To assess knowledge, attitude and practice towards COVID-19 among private school teachers. Method A web based cross-sectional analytical study design was undertaken. Currently working private school teachers of Chitwan District were included as a unit of analysis. The snowball sampling technique was employed to identify the eligible participant. Collected data was entered in SPSS version 20 and analyzed using the Chi-square test, Pearson correlation, and binary logistic regression. Result Of 344 participants, the majority were male (52.9%), most of the participants were from age group 26-30 years (38.4%). Regarding knowledge, attitude and practice, 57% had good knowledge, 53.2% had favorable attitude and 51.7% had good practice towards COVID-19. Logistic regression analysis demonstrated gender (OR 0.475, 95% CI: 0.256-0.818) and COVID-19 training (OR 25.687, 95% CI 5.354-123.226) were significant with good knowledge. Conclusion Knowledge about COVID-19 among private schools teacher was good, attitudes have been mostly favorable, and the practices were mostly adequate. However, good knowledge is not the only factor for better attitude and good practices. It is necessary to implement massive education campaigns, trainings and information via school authorities and health authorities by developing and adopting appropriate guidelines on COVID-19. KEY WORDS Attitude-practice, COVID-19, Knowledge, School teacher
Pseudomembranous colitis in a pregnant woman
(Kathmandu University, 2010) Mridula, T; Pai, RR; Mathai, AM; Tantry, BV; Adhikari, P
ABSTRACT Pseudomembranous colitis in association with pregnancy has not been well described in English literature. Recent studies show a drastic increase in the incidence and severity of Pseudomembranous colitis in pregnant women, who were once thought to be at low risk. We report here a case of Pseudomembranous colitis in a young healthy immunocompetent pregnant lady. An early suspicion of this entity with the characteristic appearance of pseudomembranes on colonoscopy and histology confirmed the diagnosis enabling prompt treatment and complete recovery without any serious consequences. Key Words immunocompetent, pregnancy, pseudomembranous colitis

Browsing by Author "Adhikari, P"

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