Browsing by Author "Akhter, J"
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Publication Evaluation of fine needle aspiration cytology of lymph nodes in Kathmandu Medical College, Teaching hospital(Kathmandu University, 2009) Hirachand, S; Lakhey, M; Akhter, J; Thapa, BAbstract Background: Fine Needle Aspiration Cytology (FNAC) is a simple and rapid diagnostic technique. Because of early availability of results, simplicity, minimal trauma and complications, the aspiration cytology is now considered a valuable diagnostic aid and is part and parcel of a pathologist’s repertoire. Objectives: The aim of the study was to evaluate the results of fine needle aspiration cytology (FNAC) of lymph nodes in our institution in comparison to result of histopathology. Materials and methods: The present study on 130 patients of lymphadenopathy was conducted in the Department of Pathology Kathmandu Medical College Teaching hospital, Kathmandu from June 2006 to May 2008 (2 years). Results: In this series of FNAC cervical lymph nodes were 66 (50.76%), and axillary lymph nodes were 20 (15.38%). Male to female ratio of the patients was 1: 0.9. Th age of patients ranged from 3 to 85 years. FNAC diagnosis was found to be as follows : reactive hyperplasia 54( 41.55%), tubercular lymphadenitis 36 (28 %), metastatic carcinoma 16 (12.3%), granulomatous lymphadenitis 12 ( 9.2 % ), lymphoma 8 (6%) and suppurative lymphadenitis 4(3%) . Out of 28 cases of FNAC 26 (92.85%) were consistent with histopathological diagnosis of tubercular lymphadenitis. In metastatic carcinoma to lymph nodes sensitivity and specificity of FNAC were 100% each. Conclusion: FNAC is useful and reliable in diagnosing neoplastic and non- neoplastic lesions of lymph nodes. It helps in planning surgery for malignant cases, where definitive operative intervention can be performed in one session. Key words: FNAC, lymphadenopathy.Publication Fine needle aspiration (FNA) of soft tissue tumours (STT)(Kathmandu Unversity, 2007) Hirachand, S; Lakhey, M; Singha, AK; Devkota, S; Akhter, JObjectives: The cytological findings of 50 ST Ts were evaluated aiming to determine the role of FNA in diagnosis of STTs Methods: Fifty patients with soft tissue tumours underwent FNA in the preoperative investigation during a one year period. The smears were stained with Papanicolaou and May-Graunvald Giemsa stains. Results: Forty-four cases were reported as benign, whereas 2 were malignant. Four cases revealed insufficient material. The malignant STTs were small round cell tumour and malignant spindle cell tumour. Cytological and histological correlation could be achieved in 40 cases. The overall sensitivity and specificity were 25% and 100% respectively with overall accuracy of 80%. Conclusion: A reliable diagnosis of STTs can be made with FNA when supported by other clinical and other diagnostic data. Key words: FNA, soft tissue tumoursPublication Rapid detection of helicobacter pylori by endoscopic brush cytology and comparison with histopathology(Kathmandu University, 2007) Akhter, J; Shrestha, HGObjectives: The main objective of this study was to assess antral brush cytology as an alternate approach for the diagnosis of H. pylori infection as compared to histopathology. Methods: 75 cases with diagnosis of antral gastritis underwent endoscopic antral biopsy as well as antral brushing cytology was included irrespective of age and sex. Cytological slides were stained with Giemsa stain & biopsy slides were stained with H&E and Giemsa stain. Correlation was done between cytological smear slides and biopsy slides. Results: Among 75 cases, H. pylori were positive in 55 (73.4%) cases of biopsy specimens while in brush cytology it was positive in 48 (64%) cases. In 45 (60%) of 75 cases, H. pylori was seen in both biopsy and brush cytology. Conclusion: Endoscopic brush cytology provides an accurate, inexpensive and easy technique in the rapid detection of H.pylori infection. Key words: Brush cytology, H.pyloriPublication Role of FNAC in the diagnosis of salivary gland swellings(Kathmandu University, 2008) Akhter, J; Hirachand, S; Lakhey, MAbstract Objectives: The aim of this study was to evaluate the diagnostic accuracy and efficacy of Fine Needle Aspiration Cytology (FNAC) in various salivary gland swellings. Materials and methods: This retrospective study was performed at Kathmandu Medical College Teaching Hospital (KMCTH) from January 2004- December 2006. During this period a total of 978 FNAC’s were done out of which 40 FNAC’s were on salivary gland swellings. Correlation was done between cytological smear slides and biopsy slides. Results: In this series of FNAC, 16 cases (40%) were benign neoplasms, 5 cases (12.5%) malignant neoplasms, non- neoplastic cysts 3 cases (7.5%) and inflammatory lesions 16 cases (40%).Histopathology was available in 24 cases out of which 22 cases correlated with cytology.There were no false positive reports but false negative result was seen in 4 cases.Sensitivity and specificity were 90% and 100% respectively. Conclusion: FNAC is useful in the diagnosis of salivary gland swellings especially in benign conditions with a sensitivity of 90% and specificity of 100%. Key words: Fine needle aspiration cytology (FNAC); Salivary gland swelling (SGS)