Browsing by Author "Bhandari, Sajana"
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Publication Dermoscopy of Non-Melanocytic Skin Tumors: A Descriptive Study in a Tertiary Care Hospital(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2022) Thapa, Deeptara Pathak; Bhandari, Sajana; Adhikari, Harihar; Joshi, SammiAbstract: Introduction: Dermoscopy is a non-invasive technique that enhances visualization of morphological lesions invisible to naked eye examination and aids in clinical diagnosis. We study its role in non-melanocytic skin tumors. Objectives: The purpose of this study was to evaluate and compare the dermoscopic features of non-melanocyte skin tumors of skin Materials and Methods: A cross-sectional hospital-based study including patients clinically diagnosed as non-melanocytic epidermal tumors was conducted. All dermoscopic findings were studied using a handheld pocket dermoscope (Dermlite DL1) and recorded in a preset proforma. Results: A total of 100 patients were enrolled in the study with mean age of 37 (+/-18.34). There were 56 % females. The face was the commonest site of involvement (56%). Seborrheic keratosis was the commonest clinical diagnosis (55%), followed by pyogenic granuloma 8%, cherry angioma 7%, haemangioma 6%, basal cell carcinoma 5%, achrochordons 4%, xanthelasma, and sebaceous hyperplasia in 3% each. Squamous cell carcinoma and actinic keratosis were seen in 2% each; Angiokeratoma, Bowens disease, stetocytoma multiplex, syringoma, and neurofibroma were all found in 1% of the patients. In dermoscopy, vascular changes were seen in 41% patients, which appeared as regular in 56.1% and rest 43.9% as irregular. Non-vascular changes were seen in 68%. Dermoscopic findings of vascular and non-vascular changes were statistically significantly associated with various types of non-melanocytic epidermal tumors (P <0.05). Conclusion: Our study shows histopathological correlation with the existing dermoscopic characteristics increases the diagnostic accuracy of various non-melanocytic tumors. However, more studies are warranted to statistically prove its utility.Publication Dermoscopy of Psoriasis: A Cross Sectional Study(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2022) Thapa, Deeptara Pathak; Adhikari, Harihar; Bhandari, SajanaAbstract: Introduction: Dermoscopy is a non-invasive tool that aids in the diagnosis of dermatological diseases. Objectives: The study aims to evaluate the dermoscopic features of psoriasis in the skin. Materials and Methods: All patients clinically diagnosed with psoriasis were enrolled in the study. Dermoscopic findings were studied using a handheld pocket dermoscope (Dermlite DL1) with high magnification. Dermoscopic examination used both polarizing and non-polarizing lenses. Results: The age of the patients ranged from 12 years to 58 years, and the mean age of presentation was 30 years (+/-12.7 years). There were 52% females and 48% males. In dermoscopy, vascular changes were seen in 90%. Vessel arrangement was seen as uniform in 80% of the cases and non-uniform in 20%. Dotted vessels were seen in 88%, glomerular and comma-shaped vessels in 2%. In 94%, white scales were seen, followed by yellow scales in 2% and mixed types in 4%. The background color was red in 68% of cases, pink in 26%, and brownish in 6%. Pigmentary changes were observed in 16%. Follicular changes were observed in 6%. Conclusion: The present study analyzed the characteristic of dermoscopic features in psoriasis. Further studies should be conducted, including inflammatory disorders and their correlation with dermoscopic features.Publication Helicobacter Pylori Infection Induced Henoch Schonlein Purpura: A Case Report(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2022) Bhandari, Sajana; Thapa, Deeptara PathakAbstract: Henoch Schonlein Purpura (HSP) also known as IgA vasculitis, is an immune complex vasculitis affecting small vessels. We report a case of 53 years old female who presented with multiple reddish-brown purpuric papules over bilateral lower limb for 10 days. Her cutaneous findings were suggestive of HSP. She also had a history of recurrent dyspepsia for the past 6 months for which she had been taking antacid from a local pharmacy infrequently. To confirm her diagnosis, skin biopsy was sent for both histopathological examination and direct immunofluorescence which were suggestive of HSP. We referred her to the medicine department for her gastrointestinal complaints where upper gastrointestinal endoscopy was performed and the finding was consistent with Helicobacter pylori (H. pylori) infection. The patient was started on a treatment regimen for H. pylori eradication which resulted in a dramatic improvement in both gastrointestinal complaints as well as cutaneous lesions. There are very few cases in the literature showing an association between HSP and H. pylori infection and none from our part of the world.Publication Mucocutaneous Adverse Effects of Methotrexate Toxicity: A Case Series(Nepal Medical Association, 2025) Subedi, Bibek; Neupane, Saraswoti; Bhandari, Sajana; Timilsina, Sunil; Pokhrel, SudarshanAbstract Methotrexate is a widely used medication in dermatology, rheumatology, and oncology. However, patient misunderstandings or attempts to expedite symptom relief can lead to overuse, resulting in severe toxicity. This case series presents five instances of methotrexate toxicity due to daily dosing and excessive use for underlying disorders. All patients exhibited fever, skin, and mucosal lesions, alongside abnormal hematological parameters. Management involved immediate cessation of methotrexate, administration of leucovorin rescue therapy, and supportive care. Three patients fully recovered with the resolution of lesions and improved hematological profiles, while two succumbed to the illness. These cases underscore the critical need for early recognition of methotrexate toxicity symptoms and comprehensive patient counseling on proper dosing schedules to prevent such adverse outcomes.