Browsing by Author "Bhatt, RD"
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Publication Analysis of Factors Associated with Thyroid Dysfunction: A Hospital Based Study(Kathmandu University, 2019) Risal, P; Adhikari, B; Shrestha, R; Manandhar, S; Bhatt, RD; Hada, MABSTRACT Background Thyroid dysfunction (TD) is one of the major public health concerns in Nepal. This study intends to identify factors in association with thyroid dysfunction and its hospital based prevalence. Objective To determine hospital-based prevalence of thyroid dysfunction and to identify and analyze factors in association with thyroid dysfunction. Method A retroprospective cross-sectional study was conducted among patients attending Dhulikhel Hospital-Kathmandu University Hospital (DH,KUH) from January to December, 2015 with prospective part carried out from July to December 2015 in the patients visiting Dhulikhel hospital for health check-up and requested for Thyroid Function Tests (TFTs). Thyroid Function Tests of 1530 subjects were performed in the biochemistry laboratory and semi-structured questionnaire were introduced to 312 participants with convenient sampling method and their anthropometric measurements were taken. Chi-square test, Pearson’s correlation and student-t test were used as a measure to analyze factors. Result Out of total 1530 subjects, 35.3% were having thyroid dysfunction with the prevalence of overt hyperthyroidism, subclinical hyperthyroidism, overt hypothyroidism and subclinical hypothyroidism to be 2.5%, 2.4%, 5.6% and 24.8% respectively. The distribution of thyroid dysfunction was preponderant among females and among older age. The prevalence of thyroid dysfunction was highest among Terai/Madhesi (40.0%) and lowest among Newars (28.5%) with higher fraction of hypothyroidism in each ethnic group. There were significant correlation between Thyroid Stimulating Hormone (TSH) with waist-hip ratio (p<0.05) and weight (kg) with free thyroxine (fT4) (p<0.05). Direct pesticide exposure (p<0.05) was significantly associated with hypothyroidism. The serum fT4 was significantly different (p<0.05) among vegetarian and non-vegetarian whereas TSH and free triiodothyronine (fT3) were not significantly different. Smoking, alcoholism, dietary food habits, diabetes and hypertension were not significantly associated with thyroid dysfunction. Conclusion Thyroid dysfunction was highly prevalent among participants with higher proportion of subclinical hypothyroidism. Besides, direct pesticide exposure found to be factor in association with hypothyroidism, this study could not find significance relation with other established risk factors. KEY WORDS Hyperthyroidism, Hypothyroidism, Thyroid dysfunction, Thyroid function testPublication Dietary Salt Intake in a Suburban Nepali Community: A Cross-sectional Study Using 24-Hour Urinary Sodium(Kathmandu University, 2025) Bhatt, RD; Shrestha, A; Karmacharya, BM; Timalsena, D; Dhimal, MN; Pradhan, P; Oli, N; Bista, D; Pyakurel, M; Barakoti, R; Mishra, R; Risal, PABSTRACT Background High dietary salt intake is a recognized contributor to hypertension and cardiovascular diseases, particularly in low- and middle-income countries. Despite the high burden of hypertension in Nepal, robust estimates of salt intake using the gold standard 24- hour urinary sodium collection remain scarce, especially in suburban populations. Objective To accurately assess dietary salt intake using 24-hour urinary sodium excretion and evaluate factors influencing salt consumption in a suburban Nepali population. Method A cross-sectional study was conducted in 2023-2024 as part of the Dhulikhel Heart Study’s second phase. A total of 381 adult participants were recruited from randomly selected wards of Dhulikhel Municipality. Data on sociodemographic characteristics, dietary habits, salt-related knowledge, and anthropometry were collected. Salt intake was estimated from 24-hour urinary sodium excretion. Generalized Estimating Equations (GEE) and multivariate analyses were used to identify associated factors. Result The mean age of the participants was 49.9 ± 15.5 years and average salt consumption was 9.55 ± 3.2 g/day. The mean dietary salt intake significantly exceeded WHO recommendations, with notable variations by sex, education, and frequency of eating out. Conclusion This study highlights alarmingly high salt intake in a suburban Nepali community and underscores the need for population-specific strategies to reduce sodium consumption. Policy action, public education, and promotion of healthier dietary behaviors are essential to combat the growing burden of salt-related non- communicable diseases. KEY WORDS Blood pressure, Dietary salt intake, 24-hours urine sodiumPublication Needs Assessment of Leadership and Governance in Cardiovascular Health in Nepal(Kathmandu University, 2021) Pradhan, PMS; Bhatt, RD; Pandit, R; Shrestha, A; Maharjan, R; Jha, N; Bajracharya, S; Shrestha, S; Koju, RP; Karmacharya, BMABSTRACT Background Good governance and leadership are essential to improve healthy life expectancy particularly in low and middle-income countries (LMICs). This study aimed to epitomize the challenges and opportunities for leadership and good governance for the health system to address non-communicable diseases particularly cardiovascular diseases (CVD) in Nepal. Objective The objective of this study was to understand and document CVD programs and policy formulation processes and to identify the government capacity to engage stakeholders for planning and implementation purposes. Method A national-level task force was formed to coordinate and steer the overall need assessment process. A qualitative study design was adopted using “The Health System Assessment Approach”. Eighteen indicators under six topical areas in leadership and governance in cardiovascular health were assessed using desk review and key informant interviews. Result Voice and accountability exist in planning for health from the local level. The government has shown a strong willingness and has a strategy to work together with the private and non-government sectors in health however, the coordination has not been effective. There are strong rules in place for regulatory quality, control of corruption, and maintaining financial transparency. The government frequently relies on evidence generated from large-scale surveys for health policy formulation and planning but research in cardiovascular health has been minimum. There is a scarcity of cardiovascular disease-specific protocols. Conclusion Despite plenty of opportunities, much homework is needed to improve leadership and governance in cardiovascular health in Nepal. The government needs to designate a workforce for specific programs to help monitor the enforcement of health sector regulations, allocate enough funding to encourage CVD research, and work towards developing CVD-specific guidelines, protocols, and capacity building. KEY WORDS Cardiovascular diseases, Governance, Leadership, Needs assessment, NepalPublication Nepali Translation and Reliability Analysis of Quantitative Androgen Deficiency in the Aging Male Questionnaire(Kathmandu University, 2020) Risal, P; Maharjan, A; Bhatt, RD; Tamrakar, DABSTRACT Background Androgen deficiency is diagnosed on the basis of clinical symptoms and laboratory assessment of testosterone level. Different screening tools have been developed to evaluate the sign and symptoms. Objective In this study, we examine the validity and reliability of the Nepali version of the quantitative Androgen Deficiency in Aging Male (qADAM) questionnaire to screen androgen deficiency in Nepali male. Method English dialectal quantitative Androgen Deficiency in Aging Male questionnaire was forward translated to Nepali version and backward translated. This version was reviewed by a panel of an endocrinologist, a clinical psychiatrist, a physician, and a clinical biochemist. A final Nepali version of qADAM was developed. Thirty-one healthy male aged 31-70 years were administered with the questionnaire in two separate occasions two weeks apart. Cronbach’s alpha and test-retest reliability were calculated to identify validity and reliability, respectively. Result In the Nepali translated questionnaire, Cronbach’s alpha for internal consistency from ten items is good (0.68). The Cronbach’s alpha for internal consistency from nine items without item 7 is 0.706. Seven out of ten items had an R-value of > 0.7. In the total sample, Standard Error Mean (SEM) ranged from 0.00-0.44 for qADAM. SEM% are low for all variables (0.00-11.20%). MDC95 ranged 0.00-1.234. MDC95% ranged 0.00 – 31.05% and was < 30% for majority of variables (90%). Conclusion The final translated Nepali questionnaire seems reliable and valid. A future study measuring the Nepali questionnaire with testosterone level and another biochemical test in control and androgen deficiency patients will help validate the questionnaire. KEY WORDS Nepali translation, qADAM, Reliability analysisPublication Sensitivity and Specificity of Nepali Version of Quantitative Androgen Deficiency in Aging Males (qADAM) Questionnaire in Diabetic Patients(Kathmandu University, 2023) Bhatt, RD; Risal, P; Maharjan, A; Timalsina, D; Qiqiang, HEABSTRACT Background Diabetes mellitus (DM) is a chronic disorder with hyperglycemia that affects multiple systems with hypogonadism and erectile dysfunction some common issues affecting their quality sexual life. Quantitative androgen deficiency in aging males (qADAM) questionnaire is a trusted tool to assess hypogonadism and erectile dysfunction among diabetic patients and has been commonly used in Nepal too. However, the accuracy, sensitivity, and specificity of its Nepali version are yet to be tested. Objective To assess the accuracy, sensitivity, and specificity of the Nepali version of the quantitative androgen deficiency in aging males questionnaire among diabetic patients. Method A cross-sectional study was conducted among diabetic patients attending Dhulikhel Hospital, Kathmandu University Hospital. The Patients were asked to complete the valid Nepali translated version of quantitative Androgen Deficiency in Aging Males questionnaire. Participants’ serum total and free testosterone, lipid profile, fasting blood glucose, HbA1c and Sex Hormone Binding Globulin (SHBG) were measured in clinical biochemistry laboratory and the accuracy, sensitivity and specificity of Nepali version of quantitative androgen deficiency in aging males were analyzed. Result The translated Nepali version of quantitative androgen deficiency in aging males questionnaire showed 61.9% sensitivity, 45.5% specificity, and 56.7% accuracy in diagnosing hypogonadism in reference to serum testosterone level. Conclusion This Nepali translated version of quantitative androgen deficiency in aging males questionnaire can be a noninvasive tool to assess hypogonadism and erectile dysfunction. KEY WORDS Diabetes, Hypogonadism, Nepali Translation, Quantitative androgen deficiency in aging males