Browsing by Author "Dhakal, SS"
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Publication Clinical spectrum of patients presenting with bronchiectasis in Nepal: Evidence of linkage between tuberculosis, tobacco smoking and toxic exposure to biomass smoke(Kathmandu University, 2008) Bhatta, N; Dhakal, SS; Rizal, S; Kralingen, KWV; Niessen, LAbstract Aims and objectives: The aim of the study was to describe the clinical spectrum of the patients presenting with bronchiectasis at the referral clinic for the respiratory diseases in eastern Nepal. An attempt would also be made to provide an overview of factors responsible for poor lung health in the community. Materials and methods: This is a retrospective observational study conducted at the Adult Chest Clinic of the Department of Internal Medicine at the B.P Koirala Institute of Health Sciences (BPKIHS), Dharan Nepal. The medical records of all the consecutive patients presenting with the diagnosis of bronchiectasis in the Adult Chest Clinic of Department of Medicine from January 2003 to December 2004 (two years) were reviewed for patient characteristics (age, gender, place of residence, occupation, smoking history, exposure to indoor air pollution due to use of biomass smoke, past and family history related to tuberculosis, and clinical characteristics such as clinical features and duration of symptoms Results: During the study period of two years, 100 patients presented with the diagnosis of bronchiectasis, 80 (80%) patients were smokers and 50 (50%) patients had history of significant exposure to indoor air pollution. Abnormal Chest X-ray was seen in 85(85%) patients. Post tubercular bronchiectasis was the most common etiological diagnosis Smoking status and exposure to indoor air pollution were important determinant for hospitalisation in patients with post tubercular bronchiectasis. Conclusions: In Nepal bronchiectasis remains one of the important chronic respiratory diseases, post tubercular variety being the commonest type .Tuberculosis, tobacco smoking and exposure to indoor air pollution contributes towards higher morbidity of this diseases. Key words: Bronchieactasis, Indoor air pollution, Lung health, Tobacco smoking, TuberculosisPublication The Study of Prevalence of Helicobacter Pylori in Patients with Acne Rosacea(Kathmandu University, 2012) Bhattarai, S; Agrawal, S; Rijal, A; Majhi, S; Pradhan, B; Dhakal, SSABSTRACT Background Acne rosacea is an inflammatory disease affecting the central part of the face characterized by erythema, papules, papulo pustules and telangiectasias of unknown etiology. More recently numerous studies have described an association with Helicobacter pylori (Hp) and the extra gastric symptoms of cutaneous origin. Objectives To establish the prevalence of Helicobacter pylori (Hp) infection in the stomach in patients with rosacea based on standard Hp serological test. Methods All patients with the clinical staging of 2, 3 and 4 rosacea attending the Dermatology Out Patient Department from May 2009 – April 2010 were included in the study. Quantitative serological test using the SERION ELISA classic Helicobacter pylori IgG was done. Result A total of 26 patients were enrolled in the study with the age ranging from 26- 82 years. There were 14 males and 12 females and the male: female ratio was 1.6:1. Three (11.53%) patients presented with Grade IV rosacea, a severe clinical presentation and symptoms suggestive of acid peptic diseases were found in 14/26 (53.8%) patients. A positive serology to H. pylori was found in 17/26 (65.4%) of patients. A statistically significant correlation was found when association of H.pylori positivity in patients of rosacea compared with the seropositivity in controls. However correlation in the seropositivity was not found amongst the patients having gastritis and rosacea. Conclusion There still proves to find a correlation of Hp infection with patients with rosacea but it can still be hypothesised as a cutaneous manifestation of an internal peptic ulcer disease . KEY WORDS H.pylori, rosacea