Browsing by Author "Mathur, M"
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Publication Clinicohistological Profile of Cutaneous Tuberculosis in Central Nepal(Kathmandu University, 2014) Mathur, M; Pandey, S NABSTRACT Background There are few studies on cutaneous tuberculosis in Nepal. Objective To analyse the epidemiological, clinical and histological patterns of cutaneous TB over the past 5 years. Method Patients with cutaneous tuberculosis diagnosed from January 2010 to December 2014 at College of Medical Sciences, Chitwan, Nepal were included in the study. Chest radiography, routine investigations and screening for HIV was performed in all cases. Result A total of 47 clinical cases of cutaneous tuberculosis were diagnosed. The most commonly affected age group was 41-50 years. Male to female ratio was 1.5:1. Duration of cutaneous tuberculosis ranged from 1 month to 33 years. Lupus vulgaris was the most common clinical type (64%), followed by tuberculosis verrucosa cutis (19%). Two cases (4%) were diagnosed as papulonecrotic tuberculid. Overall, the most common site of involvement was extremities (55%) followed by head and neck, trunk, and perianal region. Histopathologic features of epitheloid cell granuloma with Langhans type giant cells were seen in 89% of cases, and in remaining 11% cases, chronic inflammatory dermatitis and nonspecific chronic dermatitis were observed. Conclusion M Tuberculosis is endemic in Nepal and the incidence of cutaneous tuberculosis at our centre was 0.1%. Lupus vulgaris was the most common type followed by tuberculosis verrucosa cutis in our study. Cutaneous tuberculosis can be accompanied by tuberculosis in internal organs and hence should be looked for. Clinicopathologic correlation is necessary to make a proper diagnosis. KEY WORDS Cutaneous tuberculosis, lupus vulgaris, NepalPublication Dermatologic Manifestations In Chronic Kidney Disease Patients On Hemodialysis(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2014) Shrestha, P; Mathur, MAbstract: Introduction: Dermatologic changes are frequently seen in chronic kidney disease (CKD) patients. Early identification of these manifestations helps timely institution of treatment and prevention of progression of CKD. Objectives: The aim of this study was to evaluate the frequency and pattern of dermatologic problems among CKD patients who are on maintenance hemodialysis in our population. Material and Methods: A hospital based cross sectional comparative study was conducted. Fifty patients with CKD on hemodialysis were compared with the same number of non CKD patients. All the patients were clinically examined. Complementary diagnostic measures such as skin biopsy, gram stain, potassium hydroxide mounting and culture sensitivity of the lesions were carried out when necessary. Results: At least one dermatologic manifestation was present in 86% of the patients and changes were seen commonly in CKD patients who had GFR <15ml/min (83.8%). Cutaneous manifestations were significantly associated with CKD patients than control (p<0.001) but not with the duration of CKD and duration of hemodialysis. Thirty seven patients (74%) were having cutaneous lesions, commonest being xerosis (52%) followed by pruritus (40%) and hyperpigmentation (32%). Nail, mucous membrane and hair changes were present in 56%, 22% and 12% respectively, commonest being white nail (30%), furred tongue (18%), telogen effluvium (10%) respectively. Conclusion: In our study, dermatologic manifestations were common in CKD patients with GFR <15ml/min. Cutaneous and nail changes were seen in 74% and 56% of the CKD patients undergoing hemodialysis, commonest changes being xerosis and white nail respectively. Keywords: Dermatologic manifestations, CKD, HemodialysisPublication Disseminated Superficial Actinic Porokeratosis(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2010) Kumari, S; Mathur, MAbstract A Case Report about a rare Geno dermatosis -Dissamenated Superficial Actinic Porokeratosis is presented. Key Words: Classic porokeratosis of Mibelli (PM); disseminated superficial actinic porokeratosis (DSAP); porokeratosis palmaris et plantaris disseminata (PPPD); linear porokeratosisPublication “Epizoonosis of Dermatophytosis”: A Clinico - Mycological Study of Dermatophytic Infections in Central Nepal(Kathmandu University, 2012) Mathur, M; Kedia, SK; Ghimire, RBKABSTRACT Background Identification of dermatophytic species in clinical settings are important not only for epidemiological but also for the treatment. Objectives Present study was carried out to find out the clinical variants of Dermatophytosis and species of fungus responsible for the disease. Methods The prospective observational analysis of 200 clinically suspected cases of dermatophytic infection attending Dermatology department of College of Medical Sciences Teaching Hospital, Bharatpur, Chitwan, Nepal. Skin scraping, hair and nail samples were collected and processed according to standard protocol. Results Maximum number of patients enrolled in study were reported for treatment 5-8 weeks after the onset of disease. Overall male predominance was observed and ages between 26-30 years. Tinea corporis was the most common clinical type of tinea with female dominance in our study. 10 % of cases were having extensive Tinea. 71.5% of samples were positive on direct microscopy and 62 % positive on culture. Samples from T capitis were highest positive by direct microscopy (80%) and over all dominant species of fungus isolated in our study was Trichophyton verrucosum (30.6%). Conclusions The study highlighted Tinea corporis as the most common clinical type with female predominance. Overall predominant causative fungal species isolated was Trichophyton verrucosum. KEY WORD Dermatophyte, epidemiological factors, superficial infection,fungal species