Browsing by Author "Pant, S"
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Publication Clinical profile of typhoid patients(Kathmandu University, 2003) KC, Mathura; Gurubacharya, DL; Shrestha, A; Pant, S; Basnet, P; Karki, DBObjective: The present study was undertaken to determine the clinical profile of typhoid fever in hospitalised patients. Design: Prospective cross-sectional study. Setting: Kathmandu Medical College and Teaching Hospital Method: Total of thirty patients above fifteen years of age who had clinical features strongly suggestive of typhoid fever and on blood culture found to be positive for salmonella typhi were analysed for clinical features. Result: Among total of thirty cases, there were 17 (57%) males and 13(43%) females. 86% of cases of typhoid fever clustered around 15-30 years of age. Predominant symptoms were fever (100%), headache (90%), abdominal Pain (37%) and constipation (33%). Common clinical signs were splenomegaly (37%), relative bradycardia (27%) and hepatomegaly (17%). None of the patients presented with complications. Conclusion: The clinical profile of typhoid fever in our study revealed not much difference from that of other studies on typhoid fever. Rose spots were not noticed and we did not find a single case of complication of typhoid fever. Probably early initiation of antibiotics prevented the complications. Key words: Typhoid fever, S. Typhi.Publication Hydranencephaly(Kathmandu University, 2010) Pant, S; Kaur, G; JK, DeAbstract Hydranencephaly is a rare congenital condition where the greater portions of the cerebral hemispheres and the corpus striatum are replaced by cerebrospinal fluid and glial tissue. The meninges and the skull are well formed, which is consistent with earlier normal embryogenesis of the telencephalon. Bilateral occlusion of the internal carotid arteries in utero is a potential mechanism. Clinical features include intact brainstem reflexes without evidence of higher cortical activity. The infant’s head size and the spontaneous reflexes such as sucking, swallowing, crying, and moving the arms and legs may all seem normal at birth. However, after a few weeks the infant usually becomes irritable and has increased muscle tone and after a few months of life, seizures and hydrocephalus (excessive accumulation of cerebrospinal fluid in the brain) may develop. Other symptoms may include visual impairment, lack of growth, deafness, blindness, spastic quadriparesis (paralysis), and intellectual deficits. Since the early behaviour appears to be relatively normal, the diagnosis may be delayed for months sometimes. There is no definitive treatment for hydranencephaly. The outlook for children with hydranencephaly is generally poor, and many children with this disorder die before their first birthday. Key words: hydranencephaly, congenital anomaly, vascular disruption, thromboplastin,