Browsing by Author "Patowary, S"
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Publication A study on the modification of anti-inflammatory and analgesic action of aspirin by nifedipine(Kathmandu University, 2007) Patowary, SIntroduction Aspirin has been used as an analgesic from time immemorial. But the recent advances on various aspects of it in reducing risk of various fatal and non fatal diseases warrant a re-look. Objective: This study has been undertaken to assess the anti inflammatory and analgesic action of aspirin and Nifedipine alone as well as in combination and their individual and synergistic effect as anti-inflammatory and analgesic drug. Materials and methods: The anti - inflammatory and anti - nociceptive effect of aspirin and nifedipine was studied in a group of albino rats of Sprague Dowly strain. Anti - inflammatory action of the drugs were tested in experimentally produced inflammatory model by injecting turpentine oil in to the synovial cavity of knee joint of rats and anti - nociceptive effect was studied by hot plate method . Results From the study it was observed that nifedipine alone was a better anti - inflammatory drug causing 40.10 percent reduction of experimentally produced inflammation in the studied rats on the 12th day of observation compared to aspirin alone(33.80 %) and aspirin - nifedipine combination (39.82%) but as an analgesic nifedipine alone (51.20%) was not found to be as effective as aspirin(88.96%) at 90 minutes of observation. However, when nifedipine was combined with aspirin, it potentiated the anti - nociceptive action of aspirin (107.64 %) at 90 minutes of observation which was statistically significant (P<0.01). Conclusion: The above finding demonstrated that the dose of Non Steroidal Anti – inflammatory Drugs (NSAIDs) probably could be reduced when it is combined with Calcium Channel Blockers (CCBs) and thus the adverse effect of NSAIDs could be reduced considerably. Student’s t test was applied for statistical analysis. Key words: Anti inflammatory, anti - nociceptive, synergistic action.Publication Pharmacogenomics – Therapeutic and ethical issues(Kathmandu University, 2005) Patowary, SPharmacogenomics deals with the genetic basis underlying variable drug response in individual patients. It encompasses sum of all genes. Numerous genes may play a role in drug response and toxicity. The newly emerging genomic technologies enable the search for relevant genes and their variants to include the entire genome and help in the search for candidate genes. Moreover pharmacogenomic analysis can identify the disease susceptibility genes representing potential new drug targets. The current concept of drug therapy is to apply treatment for a large population group whereas application of pharmacogenomic will help individual application of drug therapy or on smaller patient sub population but whether this individualized medicine will lead to improved and economically feasible therapy is yet to be seen. This is again complicated by various ethical and legal issues. In this article some of the issues are highlighted. Key words: Pharmacogenomics, SNPs.