Publication: A study on the modification of anti-inflammatory and analgesic action of aspirin by nifedipine
Date
2007
Authors
Journal Title
Journal ISSN
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Publisher
Kathmandu University
Abstract
Introduction
Aspirin has been used as an analgesic from time immemorial. But the recent advances on various aspects of it in reducing
risk of various fatal and non fatal diseases warrant a re-look.
Objective:
This study has been undertaken to assess the anti inflammatory and analgesic action of aspirin and Nifedipine alone as
well as in combination and their individual and synergistic effect as anti-inflammatory and analgesic drug.
Materials and methods:
The anti - inflammatory and anti - nociceptive effect of aspirin and nifedipine was studied in a group of albino rats of
Sprague Dowly strain. Anti - inflammatory action of the drugs were tested in experimentally produced inflammatory
model by injecting turpentine oil in to the synovial cavity of knee joint of rats and anti - nociceptive effect was studied by
hot plate method .
Results
From the study it was observed that nifedipine alone was a better anti - inflammatory drug causing 40.10 percent
reduction of experimentally produced inflammation in the studied rats on the 12th day of observation compared to aspirin
alone(33.80 %) and aspirin - nifedipine combination (39.82%) but as an analgesic nifedipine alone (51.20%) was not
found to be as effective as aspirin(88.96%) at 90 minutes of observation. However, when nifedipine was combined with
aspirin, it potentiated the anti - nociceptive action of aspirin (107.64 %) at 90 minutes of observation which was
statistically significant (P<0.01).
Conclusion:
The above finding demonstrated that the dose of Non Steroidal Anti – inflammatory Drugs (NSAIDs) probably could be
reduced when it is combined with Calcium Channel Blockers (CCBs) and thus the adverse effect of NSAIDs could be
reduced considerably. Student’s t test was applied for statistical analysis.
Key words: Anti inflammatory, anti - nociceptive, synergistic action.
Description
Patowary S
Assistant Professor, Department of Clinical Pharmacology, College of Medical Sciences, Bharatpur, Nepal