Browsing by Author "Phadke, Abhishek K"
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Publication Clinical Profile and Outcomes of Neonates with Hyperbilirubinemia Undergoing Double Volume Exchange Transfusion- A Single Centre Experience(Perinatal Society of Nepal (PESON), 2024) Janardhanan, Arjun; Raikar, Poonam Sarvesh; Varghese, Arun; Phadke, Abhishek K; Kumble, Ali; P, ChaitraAbstract: Introduction: Hyperbilirubinemia is one of the most common conditions observed in neonates. Double Volume Exchange Transfusion (DVET) is the most efficient treatment to rapidly reduce the alarmingly high serum bilirubin levels. Methods: This was a retrospective descriptive study of babies who underwent DVET for neonatal hyperbilirubinemia over a five year period. Results: Total 36 babies fulfilling the inclusion criteria were analysed. The mean age of jaundice onset was 41.77 ± 39.79 hours and mean total serum bilirubin (TSB) at admission was 22.54 ± 10.73 mg / dl. Bilirubin induced neurological damage (BIND) was seen in 14 babies at admission. Babies with BIND had significantly higher bilirubin at admission (p - 0.002) and significantly late presentation (p - 0.034) compared to babies with no BIND. Rh hemolytic disease was the most common etiology (55.56%). Most common complication of DVET was thrombocytopenia followed by hypocalcemia. All babies with no BIND had normal neurological examination at discharge. One baby with BIND had abnormal neurological findings at discharge. There was no mortality. Conclusion: DVET is a safe and effective therapy for alarmingly high bilirubin. Timely management with DVET can prevent complications of BIND.Publication Hypothyroidism gone awry: A Case Report on Van Wyk Grumbach Syndrome(Perinatal Society of Nepal (PESON), 2025) Kumble, Ali; Phadke, Abhishek K; Siriac, Anciline; Khubsad, PayalAbstract: Van Wyk and Grumbach syndrome (VWGS) is a rare condition characterized by a triad of juvenile hypothyroidism, precocious puberty, and ovarian enlargement with multiple cysts. Here is a case of a 7-year-old female child presented with vaginal bleeding without breast or pubic hair development. On examination she had short stature. Family history of acquired hypothyroidism was present in both parents. Laboratory tests confirmed severe hypothyroidism with TSH levels >100 mIU/mL. Ultrasound revealed an enlarged uterus with fluid-filled internal echoes and polycystic ovaries. Thyroxine therapy was initiated and titrated, resulting in cessation of bleeding within 3 days.