Publication: Hypothyroidism gone awry: A Case Report on Van Wyk Grumbach Syndrome
Date
2025
Article Type
Case Report
Journal Title
Journal ISSN
ISSN 1990-7974 eISSN 1990-7982
Volume Title
Pages
Pages: 49 - 51
Publisher
Perinatal Society of Nepal (PESON)
Abstract
Abstract:
Van Wyk and Grumbach syndrome (VWGS) is a rare condition characterized by a triad of juvenile hypothyroidism, precocious puberty, and ovarian enlargement with multiple cysts. Here is a case of a 7-year-old female child presented with vaginal bleeding without breast or pubic hair development. On examination she had short stature. Family history of acquired hypothyroidism was present in both parents. Laboratory tests confirmed severe hypothyroidism with TSH levels >100 mIU/mL. Ultrasound revealed an enlarged uterus with fluid-filled internal echoes and polycystic ovaries. Thyroxine therapy was initiated and titrated, resulting in cessation of bleeding within 3 days.
Description
Ali Kumble
Head of the Department,All from Department of Paediatrics, Indiana Hospital and Heart Institute, Pumpwell, Mangaluru, Karnataka 575002, India .
Abhishek K Phadke
Senior Consultant,All from Department of Paediatrics, Indiana Hospital and Heart Institute, Pumpwell, Mangaluru, Karnataka 575002, India .
Anciline Siriac
DNB Resident,All from Department of Paediatrics, Indiana Hospital and Heart Institute, Pumpwell, Mangaluru, Karnataka 575002, India .
Payal Khubsad
Consultant Endocrinologist, All from Department of Paediatrics, Indiana Hospital and Heart Institute, Pumpwell, Mangaluru, Karnataka 575002, India .
Keywords
Hypothyroidism, Precocious puberty, Ovarian cyst
Identifier
https://doi.org/10.60086/jnps.v45i2.1350