Browsing by Author "Shah, BK"
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Publication Guillain-Barré Syndrome Following Tetanus Toxoid Vaccination: A Rare Case Report From A Tertiary Care Centre(Kathmandu University, 2025) Shah, BK; Sah, S; Pandey, P; Kurmi, SABSTRACT Guillain-Barré syndrome is an acute inflammatory polyneuropathy characterized by rapidly progressive, symmetric, ascending weakness often triggered by infection or rarely vaccination. Although influenza and Corona Virus Disease-19 vaccines have been more commonly implicated, there are limited reports of Guillain–Barré syndrome following tetanus- toxoid vaccination. We report a case of 12-years- old male who developed bilateral lower limbs weakness and hoarseness of voice 3 weeks after receiving tetanus toxoid vaccine given after injury. Neurological examination revealed bilateral hypotonia in lower limb. Cerebrospinal fluid analysis showed albuminocytologic dissociation. Nerve conduction studies were consistent with acute inflammatory demyelinating polyradiculoneuropathy. The patient was treated with intravenous immunoglobulin at 0.4 g/kg/day for 5 days and discharged on 10th day of admission. This case highlights a possible temporal association between tetanus toxoid vaccination and Guillain–Barré syndrome, though the causality cannot be definitively established. Further studies are required to clarify this potential link. KEY WORDS Guillain-Barré syndrome, Pediatrics, Tetanus toxoid, VaccinationPublication Seroprevalene of hepatitis B virus among Bhutanese refugees residing in Nepal(Kathmandu University, 2005) Shah, BK; Bhattacharya, S; Parija, SCThe carrier rate of HBsAg is about 6% in Bhutan and 1% in Nepal. Since outbreaks of viral hepatitis are also known, its high prevalence in a migrated community, if any, maybe a potential threat to the local people. The present study was conducted in Beldangi 2 Extension Camp, a Bhutanese refugee camp located in eastern Nepal to know the HBsAg carrier rate among the refugees. With the help of semi-structured questionnaires, 500 volunteers enrolled were interviewed for the risk factors for HBV transmission. Blood samples of 467 subjects were tested for HBsAg by an immunoassay based on immunochromatographic sandwich principle. Out of 467 samples 4 were positive for HBsAg a prevalence rate of 0.9%. HBsAg carrier rate was found to be low in Bhutanese refugees. From the questionnaires it was also found that they were not engaged in any practice that could increase the chances of HBV transmission. The study shows that the Bhutanese refugees in Nepal in this geographical area are not a threat to the local people as far as HBV transmission is concerned. Key words: HBV, Bhutanese refugees, Nepal