Browsing by Author "Shrestha, HG"
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Publication Malignant teratoid medulloepithelioma in eye(2003) Pradhan, SB; Adhikari, RC; Shrestha, B; Sayami, G; Dali, S; Shrestha, HGNA.Publication Rapid detection of helicobacter pylori by endoscopic brush cytology and comparison with histopathology(Kathmandu University, 2007) Akhter, J; Shrestha, HGObjectives: The main objective of this study was to assess antral brush cytology as an alternate approach for the diagnosis of H. pylori infection as compared to histopathology. Methods: 75 cases with diagnosis of antral gastritis underwent endoscopic antral biopsy as well as antral brushing cytology was included irrespective of age and sex. Cytological slides were stained with Giemsa stain & biopsy slides were stained with H&E and Giemsa stain. Correlation was done between cytological smear slides and biopsy slides. Results: Among 75 cases, H. pylori were positive in 55 (73.4%) cases of biopsy specimens while in brush cytology it was positive in 48 (64%) cases. In 45 (60%) of 75 cases, H. pylori was seen in both biopsy and brush cytology. Conclusion: Endoscopic brush cytology provides an accurate, inexpensive and easy technique in the rapid detection of H.pylori infection. Key words: Brush cytology, H.pyloriPublication Study of effusion cytology in patients with simultaneous malignancy and ascites(Kathmandu University, 2006) Jha, R; Shrestha, HG; Sayami, G; Pradhan, SBObjective: To evaluate sensitivity of effusion cytology in detecting malignancy Materials and methods: Effusion cytology was studied from 37 malignancy associated and 28 non malignancy associated ascitic fluid samples. Results: Out of 65 cases, 44 (67.7%) effusions were reported negative, 15 (23.1%) were positive and 6 (9.2%) were suspicious for malignancy. Thus total 21 effusions (32.3%) were tumour cell positive. All 21 (100%) were true positive, none (0%) was false positive, 28 (63.6%) were true negative and 16 (36.4%) were false negative. Thus ascitic fluid cytology had sensitivity of 56.7% and specificity of 100%. Predictive value of positive test and negative test was 100% and 63.6% respectively. Stomach was the most common primary site of malignancy associated with ascites (11 /37 i.e. 29.7%) where as adenocarcinoma was the most common type of malignancy (11/15 i.e.73.3%) in ascitic fluid cytology. Conclusion: Ascitic fluid cytology is a simple and useful procedure with sensitivity of 56.7% and should be routinely requested. Key words: Ascitic fluid, Effusion cytology