Browsing by Author "Thapaliya, Sabin"
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Publication A Case Report on Deliberate Self-poisoning with Imidacloprid in a Young Female - Overview of a Newer Insecticide Poisoning(Institute of Medicine, 2021) Thapaliya, Sabin; Basnet, Bhupendra K; Das, Santa K; Thapa, RakshyaABSTRACT Imidacloprid is a newer insecticide of the group Neonicotinoids. It is safer to humans and hence considered a better alternative to organophosphorus compounds, especially in areas like Nepal with higher incidence of deliberate self-poisoning. There has been an increase in the number of reported cases of imidacloprid poisoning from South-East Asian countries, but none from Nepal. We report a case admitted in Intensive Care Unit with neurological manifestations, respiratory failure and development of Acute Kidney Injury following acute imidacloprid poisoning. Keywords: Acute kidney injury, imidacloprid poisoning, neurological manifestation, respiratory failurePublication Essential Thrombocythemia among Patients with Myeloproliferative Neoplasms in Haematology Unit of a Tertiary Care Centre: A Descriptive Cross-sectional Study(Nepal Medical Association, 2022) Sah, Sanjit Kumar; Shah, Sangam; Tiwari, Sansar Babu; Poudel, Basanta Sharma; Singh, Biranmol; Sharma, Prakash; Acharya, Sunil Sharma; Murarka, Hritik; Thapaliya, Sabin; Shrestha, AnjanAbstract Introduction: Essential thrombocythemia, a myeloproliferative condition with an increased number of circulating platelets, is a rare hematological malignancy. The aim of the study is to find out the prevalence of essential thrombocythemia among patients with myeloproliferative neoplasms presenting in haematology unit of a tertiary care centre. Methods: This was a descriptive cross-sectional study at a tertiary care centre from September, 2020 to September, 2021 (Reference number: 48 (6-11) E2077/076). All the patients with a diagnosis of essential thrombocythemia and willing to give consent were included in the study while the patients with incomplete investigations were excluded. A sample size of 72 patients was taken and convenience sampling was done. Data were entered in Microsoft Excel 2010 and analysis was done by the Statistical Package for the Social Sciences Version 22.0. Point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data along with mean and standard deviation for continuous data. Results: Among 72 patients with myeloproliferative neoplasms, the prevalence of essential thrombocythemia was found to be 17 (23.61%) (13.80-33.42 at a 95% Confidence Interval). The mean age of patients was 55.41±11.20 years with a male to female ratio of 9:8. The mean hemoglobin level and platelet count in patients were found to be 11.20±2.1 g/dl and 677000±262067.70 cells/mm3. Twelve (70.58%) of total patients were under low risk of essential thrombocythemia while 3 (17.64%) of them were at high risk. Conclusions: The prevalence of essential thrombocythemia was similar to other studies done in similar settings.Publication Essential Thrombocythemia among Patients with Myeloproliferative Neoplasms in Haematology Unit of a Tertiary Care Centre: A Descriptive Cross-sectional Study(Nepal Medical Association, 2022) Sah, Sanjit Kumar; Shah, Sangam; Tiwari, Sansar Babu; Poudel, Basanta Sharma; Singh, Biranmol; Sharma, Prakash; Acharya, Sunil Sharma; Murarka, Hritik; Thapaliya, Sabin; Shrestha, AnjanAbstract: Introduction: Essential thrombocythemia, a myeloproliferative condition with an increased number of circulating platelets, is a rare hematological malignancy. The aim of the study is to find out the prevalence of essential thrombocythemia among patients with myeloproliferative neoplasms presenting in haematology unit of a tertiary care centre. Methods: This was a descriptive cross-sectional study at a tertiary care centre from September, 2020 to September, 2021 (Reference number: 48 (6-11) E2077/076). All the patients with a diagnosis of essential thrombocythemia and willing to give consent were included in the study while the patients with incomplete investigations were excluded. A sample size of 72 patients was taken and convenience sampling was done. Data were entered in Microsoft Excel 2010 and analysis was done by the Statistical Package for the Social Sciences Version 22.0. Point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data along with mean and standard deviation for continuous data. Results: Among 72 patients with myeloproliferative neoplasms, the prevalence of essential thrombocythemia was found to be 17 (23.61%) (13.80-33.42 at a 95% Confidence Interval). The mean age of patients was 55.41±11.20 years with a male to female ratio of 9:8. The mean hemoglobin level and platelet count in patients were found to be 11.20±2.1 g/dl and 677000±262067.70 cells/mm3. Twelve (70.58%) of total patients were under low risk of essential thrombocythemia while 3 (17.64%) of them were at high risk. Conclusions: The prevalence of essential thrombocythemia was similar to other studies done in similar settings.Publication Fasting Serum Magnesium Level and its Association with Type 2 Diabetes Mellitus and its Chronic Complications(Institute of Medicine, 2021) Lamsal, Manoj; Thapaliya, Sabin; Thapa, Pradeep; Bhandari, Roshan; Sangroula, Raj K; Sayami, Matina; Shrestha, Pradeep KABSTRACT Introduction: Diabetes mellitus is one of the most common metabolic disorders. Hypomagnesemia is a common feature in patients with type 2 diabetes mellitus (T2DM). This study aims to assess the serum magnesium level and its association with chronic complications in patients with T2DM. Methods: A total of 173 T2DM patients at Tribhuvan University Teaching Hospital were evaluated from July 2016 to August 2017. Patients were investigated for fasting serum magnesium level, fasting plasma glucose (FPG), postprandial plasma glucose (PPG), Glycosylated haemoglobin (HbA1c) and also target organ evaluation for diabetes. Data was analyzed using Statistical Package for the Social Sciences (SPSS) version 20. Results: Hypomagnesemia was found in 86 patients out of the 173 enrolled patients. Observations revealed significant association between hypomagnesemia and various microvascular complications viz. retinopathy (p=0.001), neuropathy (p<0.001) and nephropathy (p<0.001). There was also a significant association between hypomagnesemia and FPG (p=0.008) and HbA1c (p=0.009). The overall prevalence of hypomagnesemia among T2DM patients was 49.7% and the prevalence of hypomagnesemia was significantly higher (74%) among diabetic patients with microvascular complications (p=0.001) compared to diabetics with no microvascular complications. Conclusion: There was a high prevalence of hypomagnesemia among T2DM patients. A significant association was seen between hypomagnesemia and various microvascular complications like retinopathy, neuropathy and nephropathy. Routine surveillance and timely treatment of hypomagnesemia is advisable for patients with T2DM. Keywords: Diabetic retinopathy; glycosylated haemoglobin; hypomagnesemia; type 2 diabetes mellitusPublication Old World Mucosal Leishmaniasis Treated with a Single Dose of Amphotericin: A Case Report(Institute of Medicine, 2024) Thapaliya, Sabin; Poudyal, Prasanta; Tripathi, Prashant; Thapa, Milan; Anjan, ShresthaABSTRACT Mucosal leishmaniasis, an uncommon disease in the old world, is recognized as an occasional complication of donovani related visceral leishmaniasis. It usually affects the spleen, liver, skin, mucosa of the respiratory tract and, less commonly, the oral cavity. Our case was a young adult with non-healing lesions in the oropharyngeal region who was diagnosed as mucosal leishmaniasis during evaluation for suspected mucosal carcinoma. The diagnosis was made with the rK39 strip-test after multiple futile test results. A single dose of liposomal amphotericin B cured the disease. Keywords: Leishmania donovani; leishmaniasis; mucosalPublication Pharmacotherapy of Hospitalized Patients with COVID-19 at a Tertiary Care Hospital in Nepal(Institute of Medicine, Tribhuvan University, 2025) Mudvari, Anish; Prasad, Pravin; Pokharel, Akritee; Thapaliya, Sabin; Maharjan, Bindira; Khadka, Rebanta; Lamsal, Arun Batsa; Ghimire, Ranjeet; Bista, ApekshaABSTRACT: Introduction The COVID-19 pandemic poses a major health threat with no standardized treatments for SARS-CoV-2. This study evaluates pharmacotherapy trends in COVID-19 patients during the second wave at a tertiary care facility. Methods A retrospective, observational, cross-sectional study was conducted in a tertiary care centre, utilising patient data from April 2021 to July 2021. The sample included 310 patients admitted with a confirmed diagnosis of COVID-19. Patients were classified based on oxygen requirement levels, and data were analysed using descriptive statistics. Results Of the 310 patients, 59% were male and 41% female, with a mean age of 53.37 ± 17.01 years. The average hospital stay was 10 ± 7.15 days. Most patients (66.8%) required supplemental oxygen, and 7.4% required mechanical ventilation. The majority received antibacterial therapy (307, 99.03%), with ceftriaxone being the most commonly prescribed antibiotic (73.22%). Remdesivir was the predominant antiviral, and dexamethasone was used in 88.39% of patients. Conclusion Antibiotic use was extensive among hospitalised COVID-19 patients, with ceftriaxone being the most common. Antiviral use was less frequent, with Remdesivir being the preferred choice. Dexamethasone played a crucial role in managing severe cases.Publication Ulcerative Colitis with Superior Sagittal Sinus Thrombosis: A Case Report(Nepal Medical Association, 2023) Basnet, Somika; Bhandari, Abashesh; Basnet, Bhupendra Kumar; Thapaliya, SabinAbstract Ulcerative colitis is a chronic inflammatory, idiopathic, condition of the mucosa of the colon. Cerebral venous thrombosis is one of the serious and rare complications of inflammatory bowel disease. We report a case of a 27-year-old female patient with complaints of loose stool 5 to 6 episodes per day mixed with blood for 10 days. The patient has severe per rectal bleed, not controlled despite adequate measures and a few days later developed altered sensorium and fits. This case highlights prompt diagnosis and early treatment managing both severe ulcerative colitis and sagittal venous thrombosis. Immediate recognition of her disease improved her condition drastically and increased her survival.